COSTI, Maria Paola
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 45.328
EU - Europa 21.508
AS - Asia 19.628
SA - Sud America 2.812
Continente sconosciuto - Info sul continente non disponibili 775
AF - Africa 472
OC - Oceania 57
Totale 90.580
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 44.031
IT - Italia 5.838
SG - Singapore 5.766
CN - Cina 5.593
GB - Regno Unito 5.592
DE - Germania 2.632
VN - Vietnam 2.255
BR - Brasile 2.135
HK - Hong Kong 1.911
SE - Svezia 1.855
FR - Francia 1.119
RU - Federazione Russa 958
BD - Bangladesh 871
FI - Finlandia 791
KR - Corea 694
UA - Ucraina 687
CA - Canada 647
IN - India 483
TR - Turchia 461
PL - Polonia 414
ID - Indonesia 308
BG - Bulgaria 276
AR - Argentina 248
NL - Olanda 224
JP - Giappone 217
IQ - Iraq 179
MX - Messico 179
BE - Belgio 168
ES - Italia 159
IE - Irlanda 149
ZA - Sudafrica 137
LT - Lituania 125
PK - Pakistan 108
CH - Svizzera 96
AE - Emirati Arabi Uniti 91
EC - Ecuador 91
CL - Cile 76
MY - Malesia 76
VE - Venezuela 73
AT - Austria 72
CR - Costa Rica 70
CO - Colombia 68
UZ - Uzbekistan 68
IL - Israele 64
IR - Iran 61
SA - Arabia Saudita 61
PH - Filippine 58
MA - Marocco 57
GT - Guatemala 56
HN - Honduras 56
CZ - Repubblica Ceca 51
PY - Paraguay 49
JM - Giamaica 46
JO - Giordania 46
AU - Australia 44
NI - Nicaragua 44
TT - Trinidad e Tobago 42
SV - El Salvador 41
KE - Kenya 40
PR - Porto Rico 40
DZ - Algeria 39
EG - Egitto 39
PT - Portogallo 39
RO - Romania 36
SC - Seychelles 36
TN - Tunisia 34
CW - ???statistics.table.value.countryCode.CW??? 31
UY - Uruguay 29
AZ - Azerbaigian 28
KZ - Kazakistan 27
NP - Nepal 27
ET - Etiopia 26
PE - Perù 26
TH - Thailandia 25
TW - Taiwan 25
GR - Grecia 24
GP - Guadalupe 22
LU - Lussemburgo 22
DK - Danimarca 21
EU - Europa 21
BY - Bielorussia 19
DO - Repubblica Dominicana 19
HU - Ungheria 19
AL - Albania 18
RS - Serbia 17
BO - Bolivia 16
NO - Norvegia 16
BH - Bahrain 13
EE - Estonia 13
LB - Libano 13
OM - Oman 13
SN - Senegal 13
NZ - Nuova Zelanda 12
BB - Barbados 11
KG - Kirghizistan 11
MD - Moldavia 11
PS - Palestinian Territory 11
BA - Bosnia-Erzegovina 10
QA - Qatar 10
LV - Lettonia 9
Totale 89.698
Salva come PNG Salva come JPEG
Città #
Ashburn 5.503
Southend 3.786
Santa Clara 3.642
Singapore 3.462
Fairfield 2.988
Houston 2.393
San Jose 2.152
Woodbridge 2.116
Chandler 2.082
Hong Kong 1.863
Hefei 1.788
Council Bluffs 1.591
Frankfurt am Main 1.258
Ann Arbor 1.253
Jacksonville 1.240
Seattle 1.193
Cambridge 1.155
Dearborn 1.137
Wilmington 1.075
Nyköping 1.005
Beijing 877
Modena 858
London 794
Los Angeles 729
Ho Chi Minh City 708
New York 701
Seoul 646
Chicago 529
Hanoi 519
Helsinki 511
The Dalles 447
Milan 406
Princeton 302
San Diego 281
Shanghai 272
Sofia 268
Lauterbourg 259
Moscow 259
Buffalo 255
Kraków 255
Munich 238
Eugene 229
Bologna 225
São Paulo 223
Jakarta 209
Boardman 204
Izmir 196
Dallas 191
Rome 191
Orem 184
Fremont 174
Redwood City 156
Tokyo 153
Columbus 151
Toronto 144
Salt Lake City 143
Denver 138
Dublin 134
Des Moines 131
Atlanta 130
Brussels 129
Warsaw 126
Bremen 123
Phoenix 123
Da Nang 116
Parma 107
Montreal 106
Naples 96
Porto Alegre 96
Brooklyn 95
Ottawa 93
Chennai 88
Guangzhou 88
Reggio Emilia 86
Tampa 80
Washington 79
Amsterdam 78
Haiphong 77
Elk Grove Village 74
Turin 72
Falls Church 68
Stockholm 67
Kent 66
Turku 66
Rio de Janeiro 63
Baghdad 62
Mexico City 59
Grafing 58
Johannesburg 58
Manchester 58
San Francisco 58
Tashkent 57
San José 56
Verona 56
Belo Horizonte 55
Paris 55
Dong Ket 52
Poplar 51
Brasília 50
Dhaka 50
Totale 59.199
Salva come PNG Salva come JPEG
Nome #
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1.246
STRUTTURA DEL CRISTALLO DEL COMPLESSO DI TIMIDILATO SINTETASI (TS) CON UN LIGANDO 865
TYDOCK PHARMA s.r.l. Spin Off dell'Università di Modena e Reggio Emilia che ha come fine l'attività di ricerca e sviluppo nel settore delle biotech farmaceutiche. 704
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 513
Spermidine/spermine N1-acetyltranferasemodulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistanthuman ovarian cancer cell lines 498
Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth 496
Metodo per la funzionalizzazione sito specifica di molecole proteiche 493
Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells 485
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 479
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 477
2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes 472
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 461
Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. 460
USO DI INIBITORI DELLA PTERIDINA REDUTTASI PER LA PREVENZIONE E/O IL TRATTAMENTO DI INFEZIONI PARASSITARIE 456
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 450
Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase 444
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase 444
New thymidylate synthase inhibitors induce apoptosis in melanoma cell lines 442
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 441
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 440
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth 436
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 435
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 435
Internalization and stability of a thymidylate synthase peptide inhibitor in ovarian cancer cells 425
Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines 424
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery 423
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 423
Antibacterial agent discovery using thymidylate synthase biolibrary screening 422
Translational repression of thymidylate synthase by targeting its mRNA 418
Repurposing of drugs targeting yap-tead functions 415
A condensed thiadiazolo-pyrimidine as a new efficient fluorophore. Theoretical and experimental investigation of the electronic spectra and photophysics 413
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 413
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 410
Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology 410
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 407
Structure-based studies on species-specific inhibition of thymidylate synthase 406
Biochemistry: Anchors away 400
Allosteric Inhibition of human Thymidylate Synthase. 400
pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells 398
Aprepitant as anticancer drug 397
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance 397
The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment 397
Proteomic Approach to the Detection of the Mechanism of Action of Anticancer Peptides 396
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides 394
Alanine Mutants of the Interface Residues of Human Thymidylate Synthase Decode Key Features of the Binding Mode of Allosteric Anticancer Peptides 392
Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer 391
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 389
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 386
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 384
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 383
Excited-state intramolecular proton transfer in a bioactive flavonoid provides fluorescence observables for recognizing its engagement with target proteins 381
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 380
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 377
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity 376
Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors 373
PTEROATE-PEPTIDE BIOCONJUGATE TARGETING THE FOLATE RECEPTOR IN HUMAN OVARIAN CANCER CELL LINES: TRANSPORT AND MECHANISM OF ACTION. 373
A proteomic approach to investigate the mechanism of action of anticancer peptides 371
Crystal Structure of histidine-tagged human thymidylate synthase 370
Thymidylate synthase structure, function and implication in drug discovery 369
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 369
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 368
Development of flavonoids derivatives as leads against Leishmaniasis and Trypanosomiasis-invited lecture 367
Dimer-monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer 366
Maxwell A: F1000Prime Recommendation of Evaluation [Neres J et al., ACS Chem Biol 2014]. In F1000Prime, 09 Jan 2015; DOI: 10.3410/f.725248139.793502885. F1000Prime.com/725248139#eval793502885 362
Theoretical study of electronic spectra and photophysics of uracil derivatives. 361
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development 361
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against β-lactamase 356
Biochemical effects of riluzole on Leishmania parasites 356
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections 355
Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells 355
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding 355
Current and Future Chemotherapy for Chagas Disease 354
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 353
Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors 351
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 350
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 349
ANTICANCER DRUGS 349
TSI INDUCES APOPTOSIS WITH A P53 INDIPENDENT PATHWAY IN MELANOMA CELL LINES AND IN NORMAL HUMAN MELANOCITES 347
CYCLIZATION REACTIONS OF 1,3-DIBROMOPROPAN-2-OL, 2,3-DIBROMOPROPAN-1-OL AND 1-BROMOMETHYLOXIRANE WITH 6-AMINO-2,3-DIHYDRO-2-THIOXO-4(1H)-PYRIMIDINONE 344
Pharmacological and toxicological evaluation of a new series of thymidylate synthase inhibitors as anticancer agents 344
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 343
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 342
Hotspots in an obligate homodimeric anticancer target. structural and functional effects of interfacial mutations in human thymidylate synthase 342
Oxaliplatin plus leucovorin and 5-fluorouracil (FOLFOX-4) as a salvage chemotherapy in heavily-pretreated platinum-resistant ovarian cancer 340
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use. 339
QUINOXALINE DERIVATIVES AS ANTITUBERCULOSIS AGENTS 339
Homodimeric Enzymes as Drug Targets 336
Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth 336
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 336
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy 335
The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines 334
Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer-US8916679 “B2 - Granted patent as second publication”. 333
MITO-group Multicenter italian trials in ovarian cancer and gynecological malignancies Borad of directors-translational research group 332
Thymidylate synthase inhibition: A structure-based rationale for drug design 331
Alternative strategies in medicinal chemistry to face drug resistance in anticancer therapy. 331
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 330
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase. 329
Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth 328
Targeting the trypanosomatidic enzymes pteridine reductase and dihydrofolate reductase. 327
Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors 326
Totale 40.516
Salva come PNG Salva come JPEG
Categoria #
all - tutte 328.379
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 328.379
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20224.103 0 0 0 0 243 554 249 355 621 393 1.054 634
2022/20236.286 753 755 420 606 640 893 189 601 738 102 307 282
2023/20245.651 196 276 324 410 1.984 485 280 486 138 133 384 555
2024/202514.165 599 196 431 935 2.637 1.853 975 805 1.426 644 1.699 1.965
2025/202625.808 1.687 1.175 2.028 2.919 3.786 1.807 3.241 1.301 2.414 2.465 1.685 1.300
2026/20278.444 763 1.771 2.134 2.891 885 0 0 0 0 0 0 0
Totale 90.580