COSTI, Maria Paola
 Distribuzione geografica
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Continente #
NA - Nord America 22125
EU - Europa 12405
AS - Asia 1221
SA - Sud America 57
AF - Africa 26
Continente sconosciuto - Info sul continente non disponibili 26
OC - Oceania 13
Totale 35873
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Nazione #
US - Stati Uniti d'America 22047
GB - Regno Unito 4459
IT - Italia 3117
SE - Svezia 1493
DE - Germania 819
FR - Francia 631
UA - Ucraina 597
CN - Cina 525
TR - Turchia 342
PL - Polonia 268
BG - Bulgaria 262
FI - Finlandia 230
BE - Belgio 169
IN - India 114
IE - Irlanda 90
RU - Federazione Russa 82
CA - Canada 73
VN - Vietnam 57
JP - Giappone 45
CH - Svizzera 39
NL - Olanda 37
MY - Malesia 34
IR - Iran 33
BR - Brasile 32
RO - Romania 23
ES - Italia 21
EU - Europa 21
KR - Corea 21
PT - Portogallo 15
ZA - Sudafrica 15
AR - Argentina 10
HK - Hong Kong 10
AU - Australia 8
CL - Cile 8
DK - Danimarca 8
GR - Grecia 7
ID - Indonesia 6
IL - Israele 6
MD - Moldavia 6
RS - Serbia 6
A2 - ???statistics.table.value.countryCode.A2??? 5
AT - Austria 5
JO - Giordania 5
NZ - Nuova Zelanda 5
SG - Singapore 5
EC - Ecuador 4
EG - Egitto 4
HU - Ungheria 4
TZ - Tanzania 4
CZ - Repubblica Ceca 3
MX - Messico 3
PK - Pakistan 3
SK - Slovacchia (Repubblica Slovacca) 3
TW - Taiwan 3
AM - Armenia 2
BA - Bosnia-Erzegovina 2
BD - Bangladesh 2
BO - Bolivia 2
EE - Estonia 2
IQ - Iraq 2
NO - Norvegia 2
AE - Emirati Arabi Uniti 1
AL - Albania 1
BY - Bielorussia 1
BZ - Belize 1
CO - Colombia 1
ET - Etiopia 1
GL - Groenlandia 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LT - Lituania 1
MK - Macedonia 1
NG - Nigeria 1
NP - Nepal 1
PH - Filippine 1
SI - Slovenia 1
TH - Thailandia 1
TN - Tunisia 1
Totale 35873
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Città #
Southend 3800
Fairfield 2982
Houston 2328
Woodbridge 2114
Chandler 2090
Ashburn 1287
Ann Arbor 1257
Jacksonville 1238
Dearborn 1142
Seattle 1126
Cambridge 1112
Wilmington 1047
Nyköping 1013
Modena 711
Princeton 289
San Diego 269
Sofia 261
Kraków 255
Eugene 229
Izmir 193
Beijing 188
Fremont 175
Brussels 158
Redwood City 154
Des Moines 126
Bremen 123
London 84
Milan 83
Dublin 82
Falls Church 67
Bologna 66
Parma 59
Grafing 58
Boardman 54
Dong Ket 52
Hefei 50
Helsinki 49
Rome 46
Verona 46
Norwalk 45
San Mateo 43
Milwaukee 40
Nanjing 40
Ottawa 38
Guangzhou 33
Kunming 31
Napoli 29
Padova 26
Perugia 26
Jinan 25
Phoenix 25
Saint Petersburg 23
Toronto 22
Auburn Hills 21
Ferrara 21
Reggio Emilia 21
Paris 20
Torino 19
Leawood 18
Philadelphia 18
Piacenza 18
Prato 18
Shanghai 18
Turin 18
Albinea 17
Augusta 16
Chicago 15
Indiana 15
Misterbianco 15
Naples 15
Trieste 15
Amsterdam 14
Mountain View 14
San Gimignano 14
Berlin 13
Chengdu 13
Florence 13
Segrate 13
Siena 13
Cape Town 12
Pavia 12
Ardabil 11
Brescia 11
Islington 11
Bagheria 10
Bangalore 10
Basel 10
Fuzhou 10
Hebei 10
Los Angeles 10
Negrar 10
Reggio Nell'emilia 10
Salerno 10
Tulare 10
Wuhan 10
Acate 9
Battipaglia 9
Draveil 9
Garbagnate Milanese 9
Nanchang 9
Totale 27546
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Nome #
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1018
TYDOCK PHARMA s.r.l. Spin Off dell'Università di Modena e Reggio Emilia che ha come fine l'attività di ricerca e sviluppo nel settore delle biotech farmaceutiche. 388
STRUTTURA DEL CRISTALLO DEL COMPLESSO DI TIMIDILATO SINTETASI (TS) CON UN LIGANDO 346
Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase 306
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 291
Internalization and stability of a thymidylate synthase peptide inhibitor in ovarian cancer cells 274
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase 273
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 266
Metodo per la funzionalizzazione sito specifica di molecole proteiche 265
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 258
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 244
USO DI INIBITORI DELLA PTERIDINA REDUTTASI PER LA PREVENZIONE E/O IL TRATTAMENTO DI INFEZIONI PARASSITARIE 243
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance 235
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery 233
Repurposing of drugs targeting yap-tead functions 225
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 225
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 218
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides 216
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 216
Current and Future Chemotherapy for Chagas Disease 216
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 214
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 212
The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment 212
Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. 210
2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes 208
Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines. 207
Translational repression of thymidylate synthase by targeting its mRNA 204
Antibacterial agent discovery using thymidylate synthase biolibrary screening 203
Permeation through the cell membrane of a boron-based β-lactamase inhibitor. 201
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 201
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 201
Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth 200
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 199
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth 199
pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells 199
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 198
Crystal Structure of histidine-tagged human thymidylate synthase 196
Thymidylate synthase inhibition: A structure-based rationale for drug design 195
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 193
Spermidine/spermine N1-acetyltranferasemodulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistanthuman ovarian cancer cell lines 191
Alanine Mutants of the Interface Residues of Human Thymidylate Synthase Decode Key Features of the Binding Mode of Allosteric Anticancer Peptides 191
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 191
Structure-based studies on species-specific inhibition of thymidylate synthase 189
Hotspots in an obligate homodimeric anticancer target. structural and functional effects of interfacial mutations in human thymidylate synthase 189
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 188
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 185
Excited-state intramolecular proton transfer in a bioactive flavonoid provides fluorescence observables for recognizing its engagement with target proteins 185
Thymidylate synthase structure, function and implication in drug discovery 184
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections 184
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity 183
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 182
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 182
Proteomic Approach to the Detection of the Mechanism of Action of Anticancer Peptides 182
Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells 182
Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors 181
Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors 178
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 178
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding. 178
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent 178
Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors 177
Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells 177
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 175
Theoretical analysis of the addition of hydroxylamine to uracil and 5-fluorouracil as a model for the Thymidylate synthase reaction 174
Update on antifolate drugs targets 172
Dimer-monomer equilibrium of human thymidylate synthase monitored by fluorescenceresonance energy transfer. 172
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity 172
Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer 172
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus 171
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 171
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 171
Maxwell A: F1000Prime Recommendation of Evaluation [Neres J et al., ACS Chem Biol 2014]. In F1000Prime, 09 Jan 2015; DOI: 10.3410/f.725248139.793502885. F1000Prime.com/725248139#eval793502885 167
The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines 167
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 166
Theoretical study of electronic spectra and photophysics of uracil derivatives. 165
Homodimeric Enzymes as Drug Targets 165
A condensed thiadiazolo-pyrimidine as a new efficient fluorophore. Theoretical and experimental investigation of the electronic spectra and photophysics 164
Protein-protein interaction inhibitors: case studies on Small Molecules and Natural Compounds. 163
CYCLIZATION REACTIONS OF 1,3-DIBROMOPROPAN-2-OL, 2,3-DIBROMOPROPAN-1-OL AND 1-BROMOMETHYLOXIRANE WITH 6-AMINO-2,3-DIHYDRO-2-THIOXO-4(1H)-PYRIMIDINONE 163
Oxaliplatin plus leucovorin and 5-fluorouracil (FOLFOX-4) as a salvage chemotherapy in heavily-pretreated platinum-resistant ovarian cancer 163
Biochemical effects of riluzole on Leishmania parasites 162
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 161
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase. 160
Inhibitor of Ovarian Cancer Cells growth by Virtual Screening: A New Thiazole Derivative Targeting Human Thymidylate Synthase 159
PTEROATE-PEPTIDE BIOCONJUGATE TARGETING THE FOLATE RECEPTOR IN HUMAN OVARIAN CANCER CELL LINES: TRANSPORT AND MECHANISM OF ACTION. 159
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy 159
Naphthalimido Derivatives as Antifolate Thymidylate Synthase Inhibitors 157
Biochemistry: Anchors away 157
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development 156
Optimization of N-alkylation in the Synthesis of Methotrexate and Pteridine-based Derivatives Under Microwave-Irradiation 156
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 155
MITO-group Multicenter italian trials in ovarian cancer and gynecological malignancies Borad of directors-translational research group 155
Structure-Based Optimization of a Non-β-lactam Lead Results in Inhibitors That Do Not Up-Regulate β-Lactamase Expression in Cell Culture 154
Ligand-Based Virtual Screening and ADME-Tox Guided Approach to Identify Triazolo-quinoxalines as Folate Cycle Inhibitors. 154
The Future of Drug Development for Neglected Tropical Diseases: How the European Commission Can Continue to Make a Difference 150
Target-based approaches for the discovery of new antimycobacterial drugs 149
Chairperson EUTROC- Mayo Conference-Berlin - Preliminary characterization of pharmacodynamic biomarkers for LR-peptide growth inhibition of ovarian cancer (OC) cell models. 148
Ortho-halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity 148
Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities 147
Targeting the trypanosomatidic enzymes pteridine reductase and dihydrofolate reductase. 147
A proteomic approach to investigate the mechanism of action of anticancer peptides 147
Totale 20116
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Categoria #
all - tutte 79695
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 79695
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2017/201878 0000 00 00 00078
2018/20194996 422273164326 280276 54440 2794811155756
2019/20208638 645279346873 11021125 1359918 743306473469
2020/20217774 750311736642 848621 558770 3811171571415
2021/20225532 246536330303 243554 249356 6263931058638
2022/20236213 759759421608 644897 213635 79112733821
Totale 36545