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Nuclear Nox4 interaction with prelamin A is associated with nuclear redox control of stem cell aging

Mesenchymal stem cells have emerged as an important tool that can be used for tissue regeneration thanks to their easy preparation, differentiation potential and immunomodulatory activity. However, an extensive culture of stem cells in vitro prior to clinical use can lead to oxidative&#...

La nuova legge elettorale alla prova dei fatti

La prima applicazione del c.d. “Rosatellum bis” ha posto in evidenza incongruenze e malfunzionamenti di aspetti e meccanismi organizzativi e procedurali che hanno recato non pochi problemi sia nella fase di votazione e di scrutinio – quali quelli concernenti i c.d. tagliandi antifrode&#...

Dual inhibition of PI3K/mTOR signaling in chemoresistant AMLprimary cells.

A main cause of treatment failure for AML patients is resistance to chemotherapy. Survival of AML cells may depend on mechanisms that elude conventional drugs action and/or on the presence of leukemia initiating cells at diagnosis, and their persistence after therapy. MDR1 gene...

Bone regeneration by novel bioactive glasses containing strontium and/or magnesium: A preliminary in-vivo study

In this work, a set of novel bioactive glasses have been tested in vivo in an animal model. The new compositions, characterized by an exceptional thermal stability and high in vitro bioactivity, contain strontium and/or magnesium, whose biological benefits are well documented in&#x...

In vitro effects of commercial mouthwashes on several virulence traits of Candida albicans, viridans streptococci and Enterococcus faecalis colonizing the oral cavity.

Oral microbiota consists of hundreds of different species of bacteria, fungi, protozoa and archaea, important for oral health. Oral mycoses, mostly affecting mucosae, are mainly caused by the opportunistic pathogen Candida albicans. They become relevant in denture-wearers elderly people, in diabe...