COSTI, Maria Paola
 Distribuzione geografica
Continente #
NA - Nord America 4.979
EU - Europa 1.806
AS - Asia 698
SA - Sud America 117
AF - Africa 89
OC - Oceania 24
Continente sconosciuto - Info sul continente non disponibili 3
Totale 7.716
Nazione #
US - Stati Uniti d'America 4.863
IT - Italia 613
CN - Cina 315
DE - Germania 255
FR - Francia 235
GB - Regno Unito 181
IN - India 100
SE - Svezia 99
CA - Canada 90
BR - Brasile 77
VN - Vietnam 75
RU - Federazione Russa 63
CZ - Repubblica Ceca 60
NL - Olanda 50
JP - Giappone 44
ZA - Sudafrica 42
KR - Corea 39
ES - Italia 37
UA - Ucraina 29
FI - Finlandia 28
IE - Irlanda 27
BE - Belgio 25
CH - Svizzera 25
AU - Australia 23
PL - Polonia 20
NG - Nigeria 18
AE - Emirati Arabi Uniti 17
CL - Cile 17
MX - Messico 15
TR - Turchia 15
GR - Grecia 13
HK - Hong Kong 13
IR - Iran 12
TH - Thailandia 11
PT - Portogallo 10
SA - Arabia Saudita 10
PK - Pakistan 9
CU - Cuba 8
AR - Argentina 7
CO - Colombia 7
GH - Ghana 7
AT - Austria 6
EC - Ecuador 6
MY - Malesia 6
PH - Filippine 6
ID - Indonesia 5
KE - Kenya 5
DZ - Algeria 4
IQ - Iraq 4
MA - Marocco 4
RO - Romania 4
TW - Taiwan 4
DK - Danimarca 3
EG - Egitto 3
HR - Croazia 3
NO - Norvegia 3
PS - Palestinian Territory 3
SG - Singapore 3
SK - Slovacchia (Repubblica Slovacca) 3
A1 - Anonimo 2
BD - Bangladesh 2
BY - Bielorussia 2
ET - Etiopia 2
HU - Ungheria 2
LT - Lituania 2
LU - Lussemburgo 2
MT - Malta 2
PE - Perù 2
RS - Serbia 2
ZW - Zimbabwe 2
CI - Costa d'Avorio 1
CY - Cipro 1
EU - Europa 1
HN - Honduras 1
IL - Israele 1
JO - Giordania 1
LV - Lettonia 1
MD - Moldavia 1
NZ - Nuova Zelanda 1
OM - Oman 1
PA - Panama 1
SD - Sudan 1
TJ - Tagikistan 1
TT - Trinidad e Tobago 1
VE - Venezuela 1
Totale 7.716
Città #
Fairfield 670
Houston 478
Ashburn 412
Seattle 330
Woodbridge 319
Santa Cruz 301
Cambridge 215
Buffalo 208
Ann Arbor 204
Wilmington 180
Modena 179
San Diego 165
Beijing 164
Stockholm 90
Des Moines 80
Dong Ket 66
Ottawa 53
Boardman 52
Chicago 49
Mountain View 47
Los Angeles 40
Bremen 35
Muizenberg 31
Wuhan 27
University Park 26
Clearwater 25
Dublin 25
Phoenix 24
Las Vegas 23
Redmond 23
Paris 22
Council Bluffs 21
New York 21
Helsinki 20
Milan 19
Bologna 18
Parma 17
Turin 17
Hangzhou 16
Henderson 16
San Francisco 16
Delhi 15
London 15
Guangzhou 14
Shanghai 14
Leuven 13
New Delhi 13
Durham 12
Munich 12
Rio De Janeiro 12
Riva 12
Amsterdam 11
Cedar Knolls 11
Dallas 11
Reggio Emilia 11
San Jose 11
Southend 11
Bengaluru 10
Madrid 10
Provo 10
Silver Spring 10
Mumbai 9
Piacenza 9
Rome 9
São Paulo 9
Athens 8
Frankfurt am Main 8
Habana 8
Lake Forest 8
Perugia 8
Rio de Janeiro 8
Toronto 8
Brussels 7
Chiang Mai 7
Saint Petersburg 7
Salerno 7
San Bruno 7
Segrate 7
Silverton 7
Sydney 7
Yongin-si 7
Carpi 6
Gambier 6
Hamilton 6
Jacksonville 6
Kraków 6
Melbourne 6
San Mateo 6
Santiago 6
Scranton 6
Warsaw 6
Amherst 5
Austin 5
Baltimore 5
Belmont-sur-Lausanne 5
Dearborn 5
Moscow 5
Nanjing 5
Napoli 5
Niterói 5
Totale 5.242
Nome #
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs, file e31e124b-f9cb-987f-e053-3705fe0a095a 535
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting, file e31e124f-6460-987f-e053-3705fe0a095a 402
Hits and Lead Discovery in the Identification of New Drugs against the Trypanosomatidic Infections, file e31e124d-e223-987f-e053-3705fe0a095a 371
Current and Future Chemotherapy for Chagas Disease, file e31e124b-f788-987f-e053-3705fe0a095a 336
Repurposing of drugs targeting yap-tead functions, file e31e124d-9360-987f-e053-3705fe0a095a 296
The Future of Drug Development for Neglected Tropical Diseases: How the European Commission Can Continue to Make a Difference, file e31e124d-25ab-987f-e053-3705fe0a095a 285
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase, file e31e124b-6883-987f-e053-3705fe0a095a 277
Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells, file e31e124b-3ceb-987f-e053-3705fe0a095a 213
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery, file e31e124d-29e1-987f-e053-3705fe0a095a 207
In silico identification and in vitro evaluation of natural inhibitors of leishmania major pteridine reductase I, file e31e124d-1613-987f-e053-3705fe0a095a 199
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology, file e31e124b-a0f6-987f-e053-3705fe0a095a 180
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform, file e31e124d-a882-987f-e053-3705fe0a095a 179
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity, file e31e124a-a916-987f-e053-3705fe0a095a 175
Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities, file e31e124d-a324-987f-e053-3705fe0a095a 172
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development, file e31e124a-99d6-987f-e053-3705fe0a095a 169
Permeation through the cell membrane of a boron-based β-lactamase inhibitor., file e31e124e-064c-987f-e053-3705fe0a095a 163
The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines, file e31e124d-da2d-987f-e053-3705fe0a095a 156
Translational repression of thymidylate synthase by targeting its mRNA, file e31e124b-1dcd-987f-e053-3705fe0a095a 155
Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer, file e31e124d-83f4-987f-e053-3705fe0a095a 150
Oxaliplatin plus leucovorin and 5-fluorouracil (FOLFOX-4) as a salvage chemotherapy in heavily-pretreated platinum-resistant ovarian cancer, file e31e124d-9fbe-987f-e053-3705fe0a095a 150
Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors, file e31e124d-a322-987f-e053-3705fe0a095a 148
Inhibitor Specificity via Protein Dynamics. Insights from the Design of Antibacterial Agents Targeted Against Thymidylate Synthase, file e31e124b-fba7-987f-e053-3705fe0a095a 140
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells, file e31e124e-3af2-987f-e053-3705fe0a095a 138
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases, file e31e124d-224a-987f-e053-3705fe0a095a 136
Intrinsic Fluorescence of the Active and the Inactive Functional Forms of Human Thymidylate Synthase, file e31e124f-8954-987f-e053-3705fe0a095a 136
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors”, file e31e124b-f1bd-987f-e053-3705fe0a095a 131
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth, file e31e124d-ca31-987f-e053-3705fe0a095a 125
In This Issue, Volume 9, Issue 5, file e31e124d-a38d-987f-e053-3705fe0a095a 123
IL GIOCO MOLECOLARE TRA DRUG DISCOVERY E CHEMICAL BIOLOGY, file e31e124d-b365-987f-e053-3705fe0a095a 120
Evidence of destabilization of the human thymidylate synthase (hTS) dimeric structure induced by the interface mutation Q62R, file e31e124d-e220-987f-e053-3705fe0a095a 116
Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma, file 115add2d-5a73-42f8-b973-dd6d459b310d 112
Feasibility Study on a Measurement Method and a Portable Measuring System to Estimate the Concentration of Cloxacillin and β -Lactamase in Milk, file e31e124c-f553-987f-e053-3705fe0a095a 99
Label-free fiber optic optrode for the detection of class C beta-lactamases expressed by drug resistant bacteria, file e31e124d-203d-987f-e053-3705fe0a095a 95
Crystallographic studies of novel inhibitors of [beta]-lactamases, file e31e124b-f25b-987f-e053-3705fe0a095a 86
Structural bases for the synergistic inhibition of human thymidylate synthase and ovarian cancer cell growth by drug combinations, file e31e124f-9c9d-987f-e053-3705fe0a095a 75
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase, file e31e124f-d4ab-987f-e053-3705fe0a095a 75
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases, file e31e124e-c3a2-987f-e053-3705fe0a095a 73
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1, file e31e1250-3f58-987f-e053-3705fe0a095a 69
Repurposing the trypanosomatidic gsk kinetobox for the inhibition of parasitic pteridine and dihydrofolate reductases, file e31e124f-f4e1-987f-e053-3705fe0a095a 65
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent, file e31e124d-a229-987f-e053-3705fe0a095a 62
DESIGNING NOVEL INHIBITORS FOR CARBAPENEMASES: A MULTIDISCIPLINARY APPROACH, file e31e124b-f3f8-987f-e053-3705fe0a095a 45
Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth, file e31e124f-91d0-987f-e053-3705fe0a095a 43
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections, file e31e1250-0d79-987f-e053-3705fe0a095a 42
Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase, file e31e1250-aac5-987f-e053-3705fe0a095a 40
Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer-US8916679 “B2 - Granted patent as second publication”., file e31e124a-c526-987f-e053-3705fe0a095a 38
Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP-1 Cells Infected with Therapeutic Failure and Drug Resistance Leishmania infantum Clinical Isolates, file b6bad831-2087-4985-b884-640d2117c5ed 36
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections, file e31e1250-6145-987f-e053-3705fe0a095a 36
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors, file e31e124e-69e0-987f-e053-3705fe0a095a 35
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1, file 1836f00f-561c-4df3-bac1-bd18d1f83edc 29
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase, file e31e124e-83be-987f-e053-3705fe0a095a 28
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds, file e31e1250-3ee5-987f-e053-3705fe0a095a 27
Exploiting Forster Resonance Energy Transfer (FRET) in the characterization of YAP:TEAD complex disruption, file ea3e26ee-bf35-461f-8e7b-5a6f2fb59d1f 27
"Structure-Based Discovery & In parallel Optimization of Novel Inhibitors of Thymidylate Synthase", file e31e124e-61a8-987f-e053-3705fe0a095a 26
pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells, file e31e1250-700f-987f-e053-3705fe0a095a 25
A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties, file a6638a6a-bdcc-4203-8baf-385dd3872252 24
Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma, file 2ddbc408-4788-4c10-b0d4-ea4913085e81 23
The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines, file e31e124d-e59b-987f-e053-3705fe0a095a 23
Proteomic contribution to the omic path for the identification of novel drugs overcoming resistance in Leishmaniasis., file e31e1250-35a4-987f-e053-3705fe0a095a 23
Structure-based design and in parallel synthesis of boronic acid inhibitors of AmpC beta-lactamase, file e31e124e-83c2-987f-e053-3705fe0a095a 22
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity, file e31e124f-f98e-987f-e053-3705fe0a095a 21
Compounds having antiparasitic activity, file e31e124d-efcc-987f-e053-3705fe0a095a 19
Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme, file e31e1250-0e2a-987f-e053-3705fe0a095a 19
LC-MS/MS Helps Characterizing THP-1 Cells Proteome After Infection with Drug Resistant Leishmania Strains, file 0caa19db-7757-42f7-83c7-c87f93104339 18
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells, file e31e124e-4716-987f-e053-3705fe0a095a 18
Insights into host-target interaction from the proteome modulation analysis through untargeted LC-MS/MS Proteomics of drug resistant L infantum-THP1 infected cells, file 6746c7dc-7dbb-42f5-87ea-a505bfbcbbc8 16
LC-MS serum proteomics reveals a panel of proteins prognostic of positive responsiveness to bevacizumab therapy in late-stages ovarian cancer patients, file f692143a-b58e-4062-a1a3-947796ac06ce 16
Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles, file 13f336c6-8fa5-4469-9fbf-02448430cda9 15
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth, file a2cae1de-bd1b-426b-91e9-1b996303dd0b 15
A dual-Omics approach to identify the modulated proteins/genes in THP-1 cells infected with different drug resistant L. infantum clinical isolates., file 33586b7c-e52d-453f-8637-aa0435af6dd5 14
Investigating the mechanism of action of the antiparasitic agent H80 through imaging techniques, file 7eee3940-3d00-4a46-a45c-070ed71b3073 14
Design, synthesis and antiparasitic evaluation of click phospholipids, file e31e1250-0194-987f-e053-3705fe0a095a 14
Advances in the set-up of a fluorescence- anisotropy assay for the search of novel inhibitors of the tead-4 complexes, file e31e1250-2cfc-987f-e053-3705fe0a095a 14
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth, file aa21c5db-c206-459d-83d7-a5a0a3c06e02 13
Current Treatments to Control African Trypanosomiasis and One Health Perspective, file e31e1250-923d-987f-e053-3705fe0a095a 13
LC-MS/MS proteomics for the rapid and selective screening of drug resistances in Leishmania infantum clinical isolates, file 4c90d831-3920-4b56-9be1-5edbe26bb5a8 11
Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library, file cd6e45e3-17cf-4847-a275-f01c5213e6e5 11
Sesquiterpene lactones with dual inhibitory activity against the trypanosoma brucei pteridine reductase 1 and dihydrofolate reductase, file e31e1250-05d9-987f-e053-3705fe0a095a 11
Targeting of the Cysteines Surface domain of the Transcriptional Enhancer Associate Domain (TEAD) for anticancer drug discovery, file e31e1250-2caa-987f-e053-3705fe0a095a 11
Hotspots in an obligate homodimeric anticancer target. structural and functional effects of interfacial mutations in human thymidylate synthase, file e31e124f-c717-987f-e053-3705fe0a095a 10
UHPLC-MS/MS screening of the hTEAD surface for the identification of novel allosteric inhibitors with anticancer activity, file 6f4870ae-57c2-4c82-a287-d586a8db0248 9
Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase, file 0ca67a23-2652-4924-b376-42980df36080 8
Structure-Based Optimization of a Non-β-lactam Lead Results in Inhibitors That Do Not Up-Regulate β-Lactamase Expression in Cell Culture, file e31e124b-398a-987f-e053-3705fe0a095a 8
Leveraging proteomic, bioinformatic and ecotoxicology models to select new targets overcoming L. Infantum drug resistent, file 3d54e8b0-e166-49a0-ae86-1419b91e2f2c 7
Development of a sensitive biochemical tool to assess the expression levels of recombinant ectopic proteins in in vitro engineered cellular systems, file a70353c0-b6be-4929-93f2-b44e59752349 7
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase, file f2c1fc1f-6f22-4143-b624-ff3091b3dce2 7
Leveraging proteomics, bioinformatics, and ecotoxicology models to select new targets overcoming L infantum drug resistance., file 9aedc03a-0314-4ccd-b778-b23bfcf97d1c 6
Expression, purification, and characterization of Transcriptional Enhancer Associated Domain (hTEAD4), a promising target for anticancer agents, file a25bd5a8-39af-4064-8f76-9b3675860556 6
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics, file e31e124d-ca30-987f-e053-3705fe0a095a 6
New insights into bioactive compounds from the medicinal plant Spathodea campanulata P. Beauv. and their activity against Helicobacter pylori, file e31e124e-38e3-987f-e053-3705fe0a095a 6
Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology, file e31e124e-3e3a-987f-e053-3705fe0a095a 6
Heterodimeric thymidylate synthases with C-terminal deletion on one subunit., file f1fc5308-11fa-40df-9e27-701b42f66a34 6
Saturation site-directed mutagenesis of Lactobacillus casei Thymidylate synthase. Mutagenesis strategy and replacement sets of Pro-196 and Pro-197, file 4629a066-6c01-479e-afcb-199cd734c40d 5
Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case, file e31e124b-f786-987f-e053-3705fe0a095a 5
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1, file e31e124b-f9f3-987f-e053-3705fe0a095a 5
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective, file cd8d8f3b-2a35-4ba4-aca0-d37636429013 4
Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors, file e31e124a-a843-987f-e053-3705fe0a095a 4
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery, file e31e124b-30c0-987f-e053-3705fe0a095a 4
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides, file e31e124b-3cea-987f-e053-3705fe0a095a 4
Hotspots in an obligate homodimeric anticancer target. structural and functional effects of interfacial mutations in human thymidylate synthase, file e31e124b-f246-987f-e053-3705fe0a095a 4
Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase, file e31e124b-f3e1-987f-e053-3705fe0a095a 4
Totale 7.900
Categoria #
all - tutte 29.420
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 29.420


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019287 0 0 0 0 0 0 0 0 0 64 131 92
2019/20201.243 85 56 43 75 82 144 203 136 141 100 95 83
2020/20211.784 89 106 133 186 159 162 108 106 96 251 197 191
2021/20221.917 182 137 92 296 226 113 75 104 110 82 336 164
2022/20231.515 58 64 279 190 111 186 113 89 68 100 177 80
2023/2024973 84 80 107 86 78 81 183 123 88 63 0 0
Totale 7.991