A label-free quantitative proteomic approach has been undertaken to study the effects of the peptide on the proteins involved in the modulated metabolic pathways, in particular those involved in the folate metabolism. Structure-activity relationships (SAR) have been performed to improve the lead peptide pharmacodynamics. All the compounds have been assayed and a protein profile set was studied to mark and validate their behavior as inhibitor of OC cell growth.

Proteomic Approach to the Detection of the Mechanism of Action of Anticancer Peptides / Genovese, Filippo; Gualandi, Alessandra; Taddia, Laura; Caselli, Monica; Ponterini, Glauco; Marverti, Gaetano; Pirondi, Silvia; R., Guerrini; M., Pela'; Pavesi, Giorgia; C., Trapella; Costi, Maria Paola. - In: JOURNAL OF PEPTIDE SCIENCE. - ISSN 1075-2617. - ELETTRONICO. - 18:(2012), pp. S145-S145. ((Intervento presentato al convegno 32 EPS symposium tenutosi a Atene nel 2-7 September 2012.

Proteomic Approach to the Detection of the Mechanism of Action of Anticancer Peptides

GENOVESE, Filippo;GUALANDI, Alessandra;TADDIA, LAURA;CASELLI, Monica;PONTERINI, Glauco;MARVERTI, Gaetano;PIRONDI, SILVIA;PAVESI, Giorgia;COSTI, Maria Paola
2012

Abstract

A label-free quantitative proteomic approach has been undertaken to study the effects of the peptide on the proteins involved in the modulated metabolic pathways, in particular those involved in the folate metabolism. Structure-activity relationships (SAR) have been performed to improve the lead peptide pharmacodynamics. All the compounds have been assayed and a protein profile set was studied to mark and validate their behavior as inhibitor of OC cell growth.
18
S145
S145
Genovese, Filippo; Gualandi, Alessandra; Taddia, Laura; Caselli, Monica; Ponterini, Glauco; Marverti, Gaetano; Pirondi, Silvia; R., Guerrini; M., Pela'; Pavesi, Giorgia; C., Trapella; Costi, Maria Paola
Proteomic Approach to the Detection of the Mechanism of Action of Anticancer Peptides / Genovese, Filippo; Gualandi, Alessandra; Taddia, Laura; Caselli, Monica; Ponterini, Glauco; Marverti, Gaetano; Pirondi, Silvia; R., Guerrini; M., Pela'; Pavesi, Giorgia; C., Trapella; Costi, Maria Paola. - In: JOURNAL OF PEPTIDE SCIENCE. - ISSN 1075-2617. - ELETTRONICO. - 18:(2012), pp. S145-S145. ((Intervento presentato al convegno 32 EPS symposium tenutosi a Atene nel 2-7 September 2012.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/886089
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