EnglishThe invention provides novel non-/9-lactam inhibitors of ^-lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (I) which is set forth in the specification. These compounds may be used with /Mactam antibiotics to treat /J-lactam-antibiotic-resistant bacterial infections. Finally, the invention provides a pharmaceutical composition comprising these compounds.
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use / Shoichet Brian, K.; Costi, Maria Paola; Tondi, Donatella. - (1998 Dec 16).
| Data di pubblicazione: | 16-dic-1998 |
| Data di concessione: | 2000 |
| Titolo: | 3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use. |
| Autore/i: | Shoichet Brian, K.; Costi, Maria Paola; Tondi, Donatella |
| Autore/i UNIMORE: | |
| Abstract: | The invention provides novel non-/9-lactam inhibitors of ^-lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (I) which is set forth in the specification. These compounds may be used with /Mactam antibiotics to treat /J-lactam-antibiotic-resistant bacterial infections. Finally, the invention provides a pharmaceutical composition comprising these compounds. |
| Handle: | http://hdl.handle.net/11380/467715 |
| Enti collegati: | Northwestern University and University of Modena and Reggio Emilia |
| Rilevanza: | Internazionale |
| Numero di deposito: | PIXXD2 WO 0035905 A1 20000622 |
| Tipologia | Brevetto |
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