TONDI, Donatella
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 13.574
EU - Europa 8.592
AS - Asia 6.961
SA - Sud America 1.050
AF - Africa 155
OC - Oceania 24
Continente sconosciuto - Info sul continente non disponibili 13
Totale 30.369
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 13.313
IT - Italia 3.218
GB - Regno Unito 1.991
CN - Cina 1.977
SG - Singapore 1.963
VN - Vietnam 847
BR - Brasile 791
DE - Germania 746
HK - Hong Kong 732
SE - Svezia 673
FR - Francia 445
RU - Federazione Russa 327
UA - Ucraina 258
TR - Turchia 242
IN - India 239
KR - Corea 239
FI - Finlandia 236
BD - Bangladesh 195
CA - Canada 141
NL - Olanda 126
PL - Polonia 117
ID - Indonesia 109
BG - Bulgaria 105
AR - Argentina 99
JP - Giappone 84
MX - Messico 75
BE - Belgio 70
IQ - Iraq 54
ES - Italia 53
ZA - Sudafrica 53
PK - Pakistan 51
IE - Irlanda 47
CL - Cile 30
CO - Colombia 28
VE - Venezuela 28
EC - Ecuador 27
IR - Iran 27
LT - Lituania 27
MA - Marocco 27
TH - Thailandia 27
AT - Austria 23
AU - Australia 22
CH - Svizzera 22
MY - Malesia 20
AE - Emirati Arabi Uniti 19
DK - Danimarca 18
PE - Perù 17
SA - Arabia Saudita 17
UZ - Uzbekistan 17
JO - Giordania 16
PH - Filippine 16
RO - Romania 16
DZ - Algeria 14
KE - Kenya 14
EG - Egitto 12
EU - Europa 12
CZ - Repubblica Ceca 11
DO - Repubblica Dominicana 11
UY - Uruguay 11
BO - Bolivia 10
TN - Tunisia 10
BY - Bielorussia 9
IL - Israele 9
NP - Nepal 9
PT - Portogallo 9
KZ - Kazakistan 8
PY - Paraguay 8
TW - Taiwan 8
CR - Costa Rica 7
ET - Etiopia 7
JM - Giamaica 7
OM - Oman 7
RS - Serbia 7
AZ - Azerbaigian 6
PA - Panama 6
SK - Slovacchia (Repubblica Slovacca) 6
KG - Kirghizistan 5
HU - Ungheria 4
NI - Nicaragua 4
NO - Norvegia 4
QA - Qatar 4
SI - Slovenia 4
AL - Albania 3
CI - Costa d'Avorio 3
EE - Estonia 3
GR - Grecia 3
AO - Angola 2
BA - Bosnia-Erzegovina 2
BH - Bahrain 2
GE - Georgia 2
GT - Guatemala 2
HN - Honduras 2
LB - Libano 2
MC - Monaco 2
MD - Moldavia 2
MN - Mongolia 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SN - Senegal 2
Totale 30.343
Salva come PNG Salva come JPEG
Città #
Houston 1.433
Santa Clara 1.300
Southend 1.275
Singapore 1.253
Ashburn 1.146
Fairfield 947
Woodbridge 747
Hong Kong 707
Chandler 701
Hefei 511
Jacksonville 502
San Jose 483
Dearborn 424
Ann Arbor 418
Wilmington 362
Cambridge 360
Seattle 358
Nyköping 351
Beijing 349
Frankfurt am Main 295
Modena 293
London 281
Ho Chi Minh City 271
Council Bluffs 226
Seoul 224
Rome 217
Los Angeles 193
New York 189
The Dalles 187
Milan 178
Hanoi 177
Helsinki 147
Princeton 113
Chicago 108
Sofia 103
Shanghai 98
Moscow 97
Lauterbourg 96
Eugene 95
Redwood City 91
San Diego 85
Izmir 80
Bremen 75
São Paulo 74
Jakarta 67
Kraków 61
Orem 61
Buffalo 60
Wildwood 60
Tokyo 57
Munich 54
Boardman 52
Brussels 49
Dallas 49
Florence 49
Guangzhou 48
Padova 47
Fremont 46
Nottingham 44
Naples 43
Chennai 42
Da Nang 42
Columbus 40
Denver 40
Des Moines 39
Warsaw 39
Porto Alegre 38
Bologna 36
Dublin 36
Istanbul 36
Nanjing 36
Napoli 36
Catania 35
Palermo 35
Salt Lake City 35
Atlanta 34
Turin 33
Manchester 31
Montreal 31
Paris 31
Ottawa 30
Haiphong 29
Toronto 29
Brooklyn 28
Dong Ket 28
Bari 27
Johannesburg 26
Mexico City 25
Philadelphia 25
San Francisco 25
Phoenix 24
Rio de Janeiro 23
Levallois-Perret 22
Redondo Beach 22
Stockholm 21
Tampa 20
Turku 20
Biên Hòa 19
Brasília 19
Ankara 18
Totale 19.672
Salva come PNG Salva come JPEG
Nome #
LexA e la risposta SOS nei batteri: design e ottimizzazione di inibitori contrastanti lo sviluppo della resistenza batterica. 2.388
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1.213
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 486
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 450
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 425
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 385
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 384
Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1 379
Structure-based studies on species-specific inhibition of thymidylate synthase 375
Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling. 358
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 356
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 355
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 355
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 342
Crystal Structure of histidine-tagged human thymidylate synthase 340
Antibiotic Drug Discovery: New Targets and Molecular Entities. 334
Thymidylate synthase structure, function and implication in drug discovery 328
ANTICANCER DRUGS 327
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 326
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 325
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 321
Structure-based virtual screening for the discovery of novel inhibitors of New Delhi Metallo-β-lactamase-1 316
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 314
A multidisciplinary approach to the design of novel inhibitors for KPC-2 310
4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases 310
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 309
The Inhibition of Extended Spectrum beta-Lactamases: Hits and Leads 307
First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase 306
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy 295
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition 288
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 284
Ten years with NDM-1 metallo β-lactamase: from structural insights to inhibitor design 282
Zing meeting on Medicinal Chemistry 2012-Lanzarote-invitated lecture 282
AmpC beta-lactamase in complex with 3-(3-nitro-phenylsulfamoyl)-thiophene-2-carboxylic acid 281
Erratum: Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 34 (E542-E549) DOI: 10.1073/pnas.1104829108) 280
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use. 277
Crystallographic studies of novel inhibitors of [beta]-lactamases 271
Phenyl boronic acids development led to validated leads active in clinical strains overexpressing KPC-2: a step against bacterial resistance. 270
Discovery of a Novel Allosteric Inhibitor PK-188 Targeting New Delhi Metallo-β Lactamases. 269
Structure-based design of inhibitors specific for bacterial thymidylate synthase 268
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein 267
Discovery and preliminary characterization of a novel inhibitor of the SOS response in Pseudomonas aeruginosa 267
Dal Ligand based design di inibitori della Timidilato Sintasi all'Analisi Comparativa dei Complessi Enzima-Inibitore 266
Amide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 262
In silico identification and experimental validation of hits active against KPC-2 β-lactamase 259
The SOS response in bacteria and the LexA transcriptional repressor. Boronic acids derivatives: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 258
AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid 257
New weapons against antimicrobial resistance: 
Targeting SOS response to recover b
 actericidal activity of antibiotics
 256
Targeting the Class A Carbapenemase GES-5 via Virtual Screening 252
Naphthofuranone derivatives as specific inhibitors of thymidylate synthases 248
Structure-Based Optimization of a Non-β-lactam Lead Results in Inhibitors That Do Not Up-Regulate β-Lactamase Expression in Cell Culture 248
Development of therapeutic agents blocking SOS activation. 247
Ortho-halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity 244
Structure-based inhibitor design vs. beta-lactamase 241
Thymidylate Synthase as a potential new target in drug resistance antimicrobial therapy. 240
NAPHTHOFURANONE DERIVATIVES AS SPECIFIC INHIBITORS OF THYMIDYLATE SYNTHASES 239
The SOS response in bacteria and the LexA transcriptional repressor: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 239
AmpC beta-lactamase in complex with 5-diformylaminomethyl-benzo[b]thiophen-2-boronic acid 237
Separation, structural determination and biological evaluation of the thymidylate synthase inhibitor 3,3-di(4'-hydroxyphenyl)-6(7)-chloro-1-oxo-1H,3H-naphtho[1,8-cd]pyran 236
Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative 235
DESIGNING NOVEL INHIBITORS FOR CARBAPENEMASES: A MULTIDISCIPLINARY APPROACH 233
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase 231
3-Aminophenylboronic acid derivative inhibitors of β-lactamases, their preparation, and their therapeutic use 230
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against RecA protein 225
Interfering with Human Thymidylate Synthase Dimerization against ovarian human carcinoma 224
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 224
Characterisation and Optimisation of Anti-LexA Nanobodies Targeting the SOS-response Pathway to Fight Antibiotic Resistance 223
Naphthalimido Derivatives as Antifolate Thymidylate Synthase Inhibitors 222
Interfering with Human Thymidylate Synthase Dimerization anti peptide design in the search of anticancer agents against ovarian human carcinoma 220
Phenylboronic acid derivative inhibitors of beta-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 219
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture 219
Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors? 218
Phenylboronic acid derivative inhibitors of ?-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 217
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase 206
Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors 197
Rapid-Throughput Technologies Applied to the Discovery of New Hits against Thymidylate synthase Enzymes 193
Exploring acyclic boronic derivatives as potent beta-lactamases inhibitors with broad spectrum activity 192
Sulfonamide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 186
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 185
Structural and thermodynamic combined studies for inhibitors binding to Thymidylate Synthase 185
Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 185
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases 185
Enhancement of the drug discovery process by integration of Structure-based drug design and combinatorial chemistry 183
Structural and Thermodynamic analysis of novel inhibitors of beta-lactmases. 183
"Structure-Based Discovery & In parallel Optimization of Novel Inhibitors of Thymidylate Synthase" 180
Designing novel inhibitors for Metallo beta-lactamases. 178
– IN SILICO SCREENING OF NOVEL INHIBITORS OF BETA-LACTAMASES 176
Structure-based design and in parallel synthesis of boronic acid inhibitors of AmpC beta-lactamase 176
A multidisciplinary approach in the successful identification of novel carbapenemases inhibitors 175
Intersite Communication in Dimeric Enzymes Highlighted by Structural and Thermodynamic Analysis of Didansyltyrosine Binding to Thymidylate Synthases 173
Structure based design and combinatorial optimization of novel Thymidylate synthase inhibitors. Meeting Abstract : 217th ACS National Meeting, Chicago March 1999 173
Structure-Based Design and In Parallel Synthesis of Boronic Acid Inhibitors of AmpC 61538;-Lactamase 173
CTM-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid 172
From ligand-based design to Hit validation of new thymidylate synthase inhibitors 172
Acyclic boronic acids mimic β-Lactamases tetrahedral intermediates leading to broad spectrum inhibitors 170
Looking for broad-spectrum inhibitors targeting carbapenemases 168
Structure-based design and solid phase synthesis of novel AmpC b-lactamase inhibitors 167
Studi termodinamici e strutturali dell’interazione tra derivati densilici e Timidilato Sintasi Batteriche 167
VIrtual screening identifies cross-class inhibitors of clinically relevant serine- and metallo-beta lactamases 164
Phenylboronic Acids Probing Molecular Recognition against Class A and Class C beta-Lactamases 163
Totale 28.801
Salva come PNG Salva come JPEG
Categoria #
all - tutte 99.190
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 99.190
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021153 0 0 0 0 0 0 0 0 0 0 0 153
2021/20221.876 80 215 116 115 78 130 95 111 233 123 340 240
2022/20232.571 258 257 175 232 279 362 94 254 277 63 170 150
2023/20242.097 85 105 121 158 607 174 172 201 49 116 126 183
2024/20255.083 208 102 154 349 994 668 458 266 518 156 526 684
2025/20268.843 506 446 666 1.131 1.313 655 1.003 548 913 837 624 201
Totale 30.734