TONDI, Donatella
 Distribuzione geografica
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Continente #
NA - Nord America 15.249
EU - Europa 8.780
AS - Asia 7.238
SA - Sud America 1.070
Continente sconosciuto - Info sul continente non disponibili 380
AF - Africa 161
OC - Oceania 25
Totale 32.903
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Nazione #
US - Stati Uniti d'America 14.911
IT - Italia 3.382
CN - Cina 2.023
GB - Regno Unito 1.997
SG - Singapore 1.989
VN - Vietnam 858
BR - Brasile 801
DE - Germania 749
HK - Hong Kong 736
SE - Svezia 673
FR - Francia 448
BD - Bangladesh 340
RU - Federazione Russa 327
UA - Ucraina 259
KR - Corea 257
TR - Turchia 246
IN - India 242
FI - Finlandia 236
CA - Canada 181
NL - Olanda 128
PL - Polonia 118
ID - Indonesia 110
BG - Bulgaria 106
AR - Argentina 101
JP - Giappone 90
MX - Messico 80
BE - Belgio 70
ES - Italia 57
IQ - Iraq 55
ZA - Sudafrica 54
PK - Pakistan 53
IE - Irlanda 48
CL - Cile 31
EC - Ecuador 30
VE - Venezuela 30
CO - Colombia 29
LT - Lituania 28
IR - Iran 27
MA - Marocco 27
TH - Thailandia 27
AT - Austria 23
AU - Australia 23
CH - Svizzera 22
MY - Malesia 22
AE - Emirati Arabi Uniti 20
DK - Danimarca 18
PE - Perù 18
PH - Filippine 18
SA - Arabia Saudita 18
JO - Giordania 17
RO - Romania 17
UZ - Uzbekistan 17
CR - Costa Rica 16
DZ - Algeria 14
EG - Egitto 14
KE - Kenya 14
EU - Europa 12
CZ - Repubblica Ceca 11
DO - Repubblica Dominicana 11
JM - Giamaica 11
UY - Uruguay 11
BO - Bolivia 10
IL - Israele 10
TN - Tunisia 10
BY - Bielorussia 9
NP - Nepal 9
PT - Portogallo 9
TW - Taiwan 9
KZ - Kazakistan 8
OM - Oman 8
PY - Paraguay 8
ET - Etiopia 7
HN - Honduras 7
RS - Serbia 7
AZ - Azerbaigian 6
GT - Guatemala 6
NI - Nicaragua 6
PA - Panama 6
SK - Slovacchia (Repubblica Slovacca) 6
KG - Kirghizistan 5
HU - Ungheria 4
NO - Norvegia 4
QA - Qatar 4
SI - Slovenia 4
AL - Albania 3
CI - Costa d'Avorio 3
EE - Estonia 3
GR - Grecia 3
SC - Seychelles 3
SV - El Salvador 3
AG - Antigua e Barbuda 2
AO - Angola 2
BA - Bosnia-Erzegovina 2
BB - Barbados 2
BH - Bahrain 2
GE - Georgia 2
LB - Libano 2
MC - Monaco 2
MD - Moldavia 2
MN - Mongolia 2
Totale 32.501
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Città #
Ashburn 1.602
Houston 1.434
Santa Clara 1.352
Southend 1.275
Singapore 1.261
Fairfield 947
Woodbridge 747
Hong Kong 710
Chandler 701
San Jose 677
Hefei 511
Jacksonville 503
Dearborn 424
Council Bluffs 423
Ann Arbor 418
Cambridge 363
Wilmington 363
Seattle 362
Beijing 355
Nyköping 351
Modena 302
Frankfurt am Main 296
London 281
Ho Chi Minh City 275
Los Angeles 231
Rome 225
Seoul 225
New York 223
Milan 212
The Dalles 188
Hanoi 180
Helsinki 147
Chicago 123
Princeton 115
Sofia 103
Shanghai 101
Moscow 97
Eugene 96
Lauterbourg 96
Redwood City 91
San Diego 87
Izmir 80
São Paulo 76
Bremen 75
Buffalo 73
Columbus 71
Jakarta 67
Kraków 61
Orem 61
Tokyo 60
Wildwood 60
Boardman 54
Munich 54
Dallas 50
Brussels 49
Florence 49
Naples 49
Guangzhou 48
Denver 47
Fremont 47
Padova 47
Nottingham 44
Chennai 43
Da Nang 42
Warsaw 41
Atlanta 40
Bologna 40
Des Moines 39
Porto Alegre 39
Istanbul 37
Toronto 37
Turin 37
Catania 36
Dublin 36
Nanjing 36
Napoli 36
Salt Lake City 36
Montreal 35
Palermo 35
Brooklyn 32
Ottawa 32
Paris 32
Haiphong 31
Manchester 31
Philadelphia 30
Phoenix 29
Bari 28
Dong Ket 28
San Francisco 28
Johannesburg 27
Mexico City 27
Rio de Janeiro 24
Levallois-Perret 22
Redondo Beach 22
Tampa 22
Ankara 21
Stockholm 21
Turku 20
Austin 19
Biên Hòa 19
Totale 20.885
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Nome #
LexA e la risposta SOS nei batteri: design e ottimizzazione di inibitori contrastanti lo sviluppo della resistenza batterica. 2.445
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1.231
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 497
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 460
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 437
Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1 410
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 396
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 395
Structure-based studies on species-specific inhibition of thymidylate synthase 386
Antibiotic Drug Discovery: New Targets and Molecular Entities. 372
Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling. 371
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 370
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 369
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 368
Thymidylate synthase structure, function and implication in drug discovery 362
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 359
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 358
Crystal Structure of histidine-tagged human thymidylate synthase 355
A multidisciplinary approach to the design of novel inhibitors for KPC-2 355
First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase 349
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 339
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 339
ANTICANCER DRUGS 338
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 329
Structure-based virtual screening for the discovery of novel inhibitors of New Delhi Metallo-β-lactamase-1 325
4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases 322
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 319
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy 319
The Inhibition of Extended Spectrum beta-Lactamases: Hits and Leads 315
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition 309
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use. 307
Phenyl boronic acids development led to validated leads active in clinical strains overexpressing KPC-2: a step against bacterial resistance. 306
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 303
Zing meeting on Medicinal Chemistry 2012-Lanzarote-invitated lecture 303
New weapons against antimicrobial resistance: 
Targeting SOS response to recover b
 actericidal activity of antibiotics
 300
Crystallographic studies of novel inhibitors of [beta]-lactamases 299
Ten years with NDM-1 metallo β-lactamase: from structural insights to inhibitor design 293
AmpC beta-lactamase in complex with 3-(3-nitro-phenylsulfamoyl)-thiophene-2-carboxylic acid 289
Erratum: Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 34 (E542-E549) DOI: 10.1073/pnas.1104829108) 289
Structure-based design of inhibitors specific for bacterial thymidylate synthase 281
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein 280
Discovery of a Novel Allosteric Inhibitor PK-188 Targeting New Delhi Metallo-β Lactamases. 280
Discovery and preliminary characterization of a novel inhibitor of the SOS response in Pseudomonas aeruginosa 279
Dal Ligand based design di inibitori della Timidilato Sintasi all'Analisi Comparativa dei Complessi Enzima-Inibitore 278
Amide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 276
Structure-based inhibitor design vs. beta-lactamase 275
The SOS response in bacteria and the LexA transcriptional repressor. Boronic acids derivatives: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 275
In silico identification and experimental validation of hits active against KPC-2 β-lactamase 274
The SOS response in bacteria and the LexA transcriptional repressor: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 268
AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid 268
Development of therapeutic agents blocking SOS activation. 262
Naphthofuranone derivatives as specific inhibitors of thymidylate synthases 259
Structure-Based Optimization of a Non-β-lactam Lead Results in Inhibitors That Do Not Up-Regulate β-Lactamase Expression in Cell Culture 259
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against RecA protein 259
Targeting the Class A Carbapenemase GES-5 via Virtual Screening 257
Thymidylate Synthase as a potential new target in drug resistance antimicrobial therapy. 255
Ortho-halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity 253
DESIGNING NOVEL INHIBITORS FOR CARBAPENEMASES: A MULTIDISCIPLINARY APPROACH 251
Separation, structural determination and biological evaluation of the thymidylate synthase inhibitor 3,3-di(4'-hydroxyphenyl)-6(7)-chloro-1-oxo-1H,3H-naphtho[1,8-cd]pyran 250
NAPHTHOFURANONE DERIVATIVES AS SPECIFIC INHIBITORS OF THYMIDYLATE SYNTHASES 249
Interfering with Human Thymidylate Synthase Dimerization against ovarian human carcinoma 248
Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative 247
AmpC beta-lactamase in complex with 5-diformylaminomethyl-benzo[b]thiophen-2-boronic acid 247
3-Aminophenylboronic acid derivative inhibitors of β-lactamases, their preparation, and their therapeutic use 244
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase 238
Interfering with Human Thymidylate Synthase Dimerization anti peptide design in the search of anticancer agents against ovarian human carcinoma 236
Naphthalimido Derivatives as Antifolate Thymidylate Synthase Inhibitors 233
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 233
Characterisation and Optimisation of Anti-LexA Nanobodies Targeting the SOS-response Pathway to Fight Antibiotic Resistance 233
Phenylboronic acid derivative inhibitors of ?-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 232
Phenylboronic acid derivative inhibitors of beta-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 230
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture 230
Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors? 229
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase 216
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 211
Rapid-Throughput Technologies Applied to the Discovery of New Hits against Thymidylate synthase Enzymes 209
Structure based design and combinatorial optimization of novel Thymidylate synthase inhibitors. Meeting Abstract : 217th ACS National Meeting, Chicago March 1999 207
Exploring acyclic boronic derivatives as potent beta-lactamases inhibitors with broad spectrum activity 207
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases 204
"Structure-Based Discovery & In parallel Optimization of Novel Inhibitors of Thymidylate Synthase" 203
Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors 202
Sulfonamide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 198
– IN SILICO SCREENING OF NOVEL INHIBITORS OF BETA-LACTAMASES 197
From ligand-based design to Hit validation of new thymidylate synthase inhibitors 196
Structural and thermodynamic combined studies for inhibitors binding to Thymidylate Synthase 195
Structural and Thermodynamic analysis of novel inhibitors of beta-lactmases. 195
Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 194
Acyclic boronic acids mimic β-Lactamases tetrahedral intermediates leading to broad spectrum inhibitors 193
Studi termodinamici e strutturali dell’interazione tra derivati densilici e Timidilato Sintasi Batteriche 191
Enhancement of the drug discovery process by integration of Structure-based drug design and combinatorial chemistry 191
Structure-based design and solid phase synthesis of novel AmpC b-lactamase inhibitors 189
Structure-based design and in parallel synthesis of boronic acid inhibitors of AmpC beta-lactamase 188
CTM-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid 186
Structure-based discovery and combinatorial optimization of novel competitive inhibitors of thymidylate synthase 185
Intersite Communication in Dimeric Enzymes Highlighted by Structural and Thermodynamic Analysis of Didansyltyrosine Binding to Thymidylate Synthases 184
Designing novel inhibitors for Metallo beta-lactamases. 184
A multidisciplinary approach in the successful identification of novel carbapenemases inhibitors 184
Phenylboronic acid derivative inhibitors of β-lactamases, their preparation, pharmaceutical compositions, and therapeutic use 181
Structure-Based Design and In Parallel Synthesis of Boronic Acid Inhibitors of AmpC 61538;-Lactamase 180
Phenylboronic Acids Probing Molecular Recognition against Class A and Class C beta-Lactamases 180
Totale 30.506
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Categoria #
all - tutte 108.153
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 108.153
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.581 0 0 116 115 78 130 95 111 233 123 340 240
2022/20232.571 258 257 175 232 279 362 94 254 277 63 170 150
2023/20242.097 85 105 121 158 607 174 172 201 49 116 126 183
2024/20255.083 208 102 154 349 994 668 458 266 518 156 526 684
2025/20269.245 506 446 666 1.143 1.348 672 1.016 553 918 841 629 507
2026/20271.767 335 663 769 0 0 0 0 0 0 0 0 0
Totale 32.903