TONDI, Donatella
 Distribuzione geografica
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Continente #
NA - Nord America 8.725
EU - Europa 6.147
AS - Asia 1.183
SA - Sud America 60
OC - Oceania 19
AF - Africa 14
Continente sconosciuto - Info sul continente non disponibili 13
Totale 16.161
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Nazione #
US - Stati Uniti d'America 8.676
IT - Italia 2.329
GB - Regno Unito 1.582
DE - Germania 618
SE - Svezia 593
CN - Cina 539
FR - Francia 254
UA - Ucraina 237
TR - Turchia 191
HK - Hong Kong 165
FI - Finlandia 129
BG - Bulgaria 104
IN - India 97
PL - Polonia 69
BE - Belgio 60
CA - Canada 39
RU - Federazione Russa 39
IE - Irlanda 35
VN - Vietnam 30
IR - Iran 26
TH - Thailandia 25
JP - Giappone 21
AR - Argentina 20
AU - Australia 17
BR - Brasile 16
DK - Danimarca 15
CH - Svizzera 14
PK - Pakistan 14
ES - Italia 13
BD - Bangladesh 12
EU - Europa 12
KR - Corea 12
MY - Malesia 12
RO - Romania 12
SG - Singapore 12
CL - Cile 11
CO - Colombia 10
NL - Olanda 9
ID - Indonesia 8
MX - Messico 8
MA - Marocco 6
PT - Portogallo 6
ZA - Sudafrica 6
AT - Austria 5
PH - Filippine 5
CZ - Repubblica Ceca 4
IL - Israele 4
LT - Lituania 4
RS - Serbia 4
SK - Slovacchia (Repubblica Slovacca) 4
TW - Taiwan 4
GR - Grecia 2
IQ - Iraq 2
NZ - Nuova Zelanda 2
PE - Perù 2
SA - Arabia Saudita 2
A1 - Anonimo 1
AN - Antille olandesi 1
BO - Bolivia 1
BY - Bielorussia 1
BZ - Belize 1
EE - Estonia 1
EG - Egitto 1
HU - Ungheria 1
JO - Giordania 1
MD - Moldavia 1
MK - Macedonia 1
NO - Norvegia 1
NP - Nepal 1
TZ - Tanzania 1
Totale 16.161
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Città #
Houston 1.410
Southend 1.275
Fairfield 946
Woodbridge 747
Chandler 701
Ashburn 537
Jacksonville 501
Dearborn 424
Ann Arbor 418
Wilmington 355
Nyköping 351
Seattle 351
Cambridge 350
Frankfurt am Main 272
Modena 263
Beijing 181
Rome 164
Hong Kong 157
Princeton 113
New York 110
Sofia 103
Eugene 95
Redwood City 91
San Diego 84
Milan 81
Izmir 79
Bremen 75
Helsinki 62
Kraków 61
Shanghai 61
Fremont 46
Padova 44
Brussels 43
Des Moines 37
Napoli 36
Nanjing 33
Guangzhou 32
Boardman 30
Catania 29
Florence 29
Dong Ket 28
London 28
Bari 26
Dublin 25
Wildwood 25
Naples 24
Paris 23
Hefei 22
Palermo 22
Istanbul 21
Bologna 20
Turin 18
San Mateo 16
Norwalk 15
Ottawa 15
Brescia 14
Brisbane 14
Grafing 13
Pescara 13
Toronto 13
Leawood 12
Augusta 11
Buenos Aires 11
Khon Kaen 11
Verona 11
Feni 10
Kunming 10
L'aquila 10
Philadelphia 10
Trieste 10
Ardabil 9
Noci 9
O'Fallon 9
Reggio Calabria 9
Berlin 8
Catanzaro 8
Centro 8
Indiana 8
Jinan 8
Kilburn 8
Parma 8
Torino 8
Auburn Hills 7
Bangalore 7
Cagliari 7
Los Angeles 7
Mangalore 7
Moscow 7
Saint Paul 7
Saint Petersburg 7
San Francisco 7
Taranto 7
Venice 7
Wuhan 7
Dallas 6
Durban 6
Falls Church 6
Jakarta 6
Lisbon 6
Manchester 6
Totale 11.498
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Nome #
LexA e la risposta SOS nei batteri: design e ottimizzazione di inibitori contrastanti lo sviluppo della resistenza batterica. 1.636
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1.034
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 284
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 275
Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1 267
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 226
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 221
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 212
Crystal Structure of histidine-tagged human thymidylate synthase 212
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 205
Structure-based virtual screening for the discovery of novel inhibitors of New Delhi Metallo-β-lactamase-1 203
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 201
Thymidylate synthase structure, function and implication in drug discovery 200
Structure-based studies on species-specific inhibition of thymidylate synthase 198
Ten years with NDM-1 metallo β-lactamase: from structural insights to inhibitor design 196
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 195
Antibiotic Drug Discovery: New Targets and Molecular Entities. 195
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 194
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 188
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 185
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 184
Targeting the Class A Carbapenemase GES-5 via Virtual Screening 181
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein 178
First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase 177
The SOS response in bacteria and the LexA transcriptional repressor. Boronic acids derivatives: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 173
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 171
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy 171
Naphthalimido Derivatives as Antifolate Thymidylate Synthase Inhibitors 168
Structure-Based Optimization of a Non-β-lactam Lead Results in Inhibitors That Do Not Up-Regulate β-Lactamase Expression in Cell Culture 166
Phenyl boronic acids development led to validated leads active in clinical strains overexpressing KPC-2: a step against bacterial resistance. 166
In silico identification and experimental validation of hits active against KPC-2 β-lactamase 166
4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases 166
ANTICANCER DRUGS 165
AmpC beta-lactamase in complex with 3-(3-nitro-phenylsulfamoyl)-thiophene-2-carboxylic acid 161
Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative 159
Ortho-halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity 159
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 157
New weapons against antimicrobial resistance: 
Targeting SOS response to recover b
 actericidal activity of antibiotics
 157
AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid 150
Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling. 148
Zing meeting on Medicinal Chemistry 2012-Lanzarote-invitated lecture 148
The SOS response in bacteria and the LexA transcriptional repressor: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 145
Structure-based design of inhibitors specific for bacterial thymidylate synthase 143
The Inhibition of Extended Spectrum beta-Lactamases: Hits and Leads 137
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition 137
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 136
Crystallographic studies of novel inhibitors of [beta]-lactamases 133
Thymidylate Synthase as a potential new target in drug resistance antimicrobial therapy. 131
Naphthofuranone derivatives as specific inhibitors of thymidylate synthases 130
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use. 130
A multidisciplinary approach to the design of novel inhibitors for KPC-2 127
Discovery of a Novel Allosteric Inhibitor PK-188 Targeting New Delhi Metallo-β Lactamases. 127
Phenylboronic acid derivative inhibitors of ?-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 126
Dal Ligand based design di inibitori della Timidilato Sintasi all'Analisi Comparativa dei Complessi Enzima-Inibitore 126
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture 126
Separation, structural determination and biological evaluation of the thymidylate synthase inhibitor 3,3-di(4'-hydroxyphenyl)-6(7)-chloro-1-oxo-1H,3H-naphtho[1,8-cd]pyran 125
NAPHTHOFURANONE DERIVATIVES AS SPECIFIC INHIBITORS OF THYMIDYLATE SYNTHASES 124
Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors 124
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 124
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase 123
Development of therapeutic agents blocking SOS activation. 122
Phenylboronic acid derivative inhibitors of beta-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 121
Amide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 121
Interfering with Human Thymidylate Synthase Dimerization against ovarian human carcinoma 121
Discovery and preliminary characterization of a novel inhibitor of the SOS response in Pseudomonas aeruginosa 121
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase 119
DESIGNING NOVEL INHIBITORS FOR CARBAPENEMASES: A MULTIDISCIPLINARY APPROACH 116
Structure-based inhibitor design vs. beta-lactamase 115
Interfering with Human Thymidylate Synthase Dimerization anti peptide design in the search of anticancer agents against ovarian human carcinoma 112
AmpC beta-lactamase in complex with 5-diformylaminomethyl-benzo[b]thiophen-2-boronic acid 107
Characterisation and Optimisation of Anti-LexA Nanobodies Targeting the SOS-response Pathway to Fight Antibiotic Resistance 103
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases 101
3-Aminophenylboronic acid derivative inhibitors of β-lactamases, their preparation, and their therapeutic use 100
Structural and thermodynamic combined studies for inhibitors binding to Thymidylate Synthase 99
Sulfonamide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 99
Rapid-Throughput Technologies Applied to the Discovery of New Hits against Thymidylate synthase Enzymes 99
Structure-Based Design and In Parallel Synthesis of Boronic Acid Inhibitors of AmpC 61538;-Lactamase 99
CTM-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid 96
Structural and Thermodynamic analysis of novel inhibitors of beta-lactmases. 95
Erratum: Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 34 (E542-E549) DOI: 10.1073/pnas.1104829108) 95
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against RecA protein 94
Structure-based design and in parallel synthesis of boronic acid inhibitors of AmpC beta-lactamase 93
Structure-based design and solid phase synthesis of novel AmpC b-lactamase inhibitors 92
Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 92
Enhancement of the drug discovery process by integration of Structure-based drug design and combinatorial chemistry 89
Phenylboronic Acids Probing Molecular Recognition against Class A and Class C beta-Lactamases 89
Structure-based discovery and combinatorial optimization of novel competitive inhibitors of thymidylate synthase 88
Studi termodinamici e strutturali dell’interazione tra derivati densilici e Timidilato Sintasi Batteriche 86
From ligand-based design to Hit validation of new thymidylate synthase inhibitors 85
Exploring acyclic boronic derivatives as potent beta-lactamases inhibitors with broad spectrum activity 82
Most Downloaded x-ray structure (1xgj) from Protein Data Bank between 07/2007-08/2008 79
Designing novel inhibitors for Metallo Beta-lactamases 76
Phenylboronic acid derivative inhibitors of β-lactamases, their preparation, pharmaceutical compositions, and therapeutic use 75
Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors? 75
Probing Molecular Recognition of Dansyl Derivatives vs Bacterial Thymidylate Synthase (TS) 72
Designing novel inhibitors for Metallo beta-lactamases. 71
VIrtual screening identifies cross-class inhibitors of clinically relevant serine- and metallo-beta lactamases 69
Looking for broad-spectrum inhibitors targeting carbapenemases 64
Structure based design and combinatorial optimization of novel Thymidylate synthase inhibitors. Meeting Abstract : 217th ACS National Meeting, Chicago March 1999 55
Acyclic boronic acids mimic β-Lactamases tetrahedral intermediates leading to broad spectrum inhibitors 55
Totale 16.214
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Categoria #
all - tutte 50.166
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 50.166
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019745 0 0 0 0 0 0 0 0 0 0 410 335
2019/20203.905 257 130 205 598 505 456 485 353 304 178 196 238
2020/20212.693 302 117 281 182 284 184 235 245 124 357 229 153
2021/20221.876 80 215 116 115 78 130 95 111 233 123 340 240
2022/20232.571 258 257 175 232 279 362 94 254 277 63 170 150
2023/20241.797 85 105 121 158 607 174 172 201 49 116 9 0
Totale 16.508