New weapons against antimicrobial resistance: Targeting SOS response to recover b actericidal activity of antibiotics

Drug Resistant Bacteria represent a global emergency, limiting the effective treatment of bacterial infections.The development of novel strategies fighting bacterial infections is strongly desirable. One such approach is a means of prolonging the lifespan of current antibiotics, namely, the development of antibiotic adjuvants, i.e. compounds that do not themselves kill bacteria but instead enhance the effect of an antibiotic. Adjuvants have potential application in a number of situations, with the most obvious being the case of formerly susceptible bacteria that have acquired resistance. Additionally, the relative infancy of the adjuvant approach means that there are likely a greater number of both undiscovered targets and previously unidentified chemical scaffolds.