EnglishThe invention provides novel non-$g(b)-lactam inhibitors of $g(b)-lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (1) which is set forth in the specification. These compounds may be used with $g(b)-lactam antibiotics to treat $g(b)-lactam-antibiotic-resistant bacterial infections. Finally, the invention provides a pharmaceutical composition comprising these compounds.
Amide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics / Shoichet, B. K.; Tondi, Donatella; Costi, Maria Paola; M., P.. - (1999 Dec 16).
| Data di pubblicazione: | 16-dic-1999 | |
| Data di concessione: | 1999 | |
| Titolo: | Amide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. | |
| Autore/i: | Shoichet, B. K.; Tondi, Donatella; Costi, Maria Paola; M., P. | |
| Autore/i UNIMORE: | ||
| Abstract: | The invention provides novel non-$g(b)-lactam inhibitors of $g(b)-lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (1) which is set forth in the specification. These compounds may be used with $g(b)-lactam antibiotics to treat $g(b)-lactam-antibiotic-resistant bacterial infections. Finally, the invention provides a pharmaceutical composition comprising these compounds. | |
| Handle: | http://hdl.handle.net/11380/467686 | |
| Enti collegati: | Ely Lilly, Indianapolis | |
| Rilevanza: | Internazionale | |
| Numero di deposito: | 60/112,450-WO/2000/035905 | |
| Tipologia | Brevetto |
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