LexA protein is a transcriptional repressor which regulates the expression of more than 60 genes belonging to the SOS global regulatory network activated by damages to bacterial DNA. Considering its role in bacteria, LexA represents a key target to counteract bacterial resistance: the possibility to modulate SOS response through the inhibition of LexA autoproteolysis may lead to reduced drug susceptibility and acquisition of resistance in bacteria. In our study we investigated boron-containing compounds as potential inhibitors of LexA self-cleavage.
Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials / Bellio, Pierangelo; Mancini, Alisia; Di Pietro, Letizia; Cracchiolo, Salvatore; Franceschini, Nicola; Reale, Samantha; de Angelis, Francesco; Perilli, Mariagrazia; Amicosante, Gianfranco; Spyrakis, Francesca; Tondi, Donatella; Cendron, Laura; Celenza, Giuseppe. - In: LIFE SCIENCES. - ISSN 0024-3205. - 241:(2020), pp. 1-9. [10.1016/j.lfs.2019.117116]
Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials
Tondi, DonatellaInvestigation
;
2020
Abstract
LexA protein is a transcriptional repressor which regulates the expression of more than 60 genes belonging to the SOS global regulatory network activated by damages to bacterial DNA. Considering its role in bacteria, LexA represents a key target to counteract bacterial resistance: the possibility to modulate SOS response through the inhibition of LexA autoproteolysis may lead to reduced drug susceptibility and acquisition of resistance in bacteria. In our study we investigated boron-containing compounds as potential inhibitors of LexA self-cleavage.
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