Non-β-lactam inhibitors of β-lactamases are provided.  In particular, the invention provides such inhibitors which are phenylboronic acids I [R1 = N-lower alkyl, (un)substituted (hetero)cyclic alkene] or a pharmaceutically acceptable salt thereof.  These compds. may be used with β-lactam antibiotics to treat β-lactam-antibiotic-resistant bacterial infections.  Finally, the invention provides a pharmaceutical compn. comprising these compds.

Phenylboronic acid derivative inhibitors of β-lactamases, their preparation, pharmaceutical compositions, and therapeutic use / Shoichet, B K; Costi, Maria Paola; Tondi, Donatella. - (1999 Dec 16).

Phenylboronic acid derivative inhibitors of β-lactamases, their preparation, pharmaceutical compositions, and therapeutic use

costi, Maria Paola;tondi, Donatella
1999-12-16

Abstract

Non-β-lactam inhibitors of β-lactamases are provided.  In particular, the invention provides such inhibitors which are phenylboronic acids I [R1 = N-lower alkyl, (un)substituted (hetero)cyclic alkene] or a pharmaceutically acceptable salt thereof.  These compds. may be used with β-lactam antibiotics to treat β-lactam-antibiotic-resistant bacterial infections.  Finally, the invention provides a pharmaceutical compn. comprising these compds.
Northwestern University, USA; Universita Degli Studi Di Modena E Reggio Emilia
WO 2000035904
Shoichet, B K; Costi, Maria Paola; Tondi, Donatella
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1170840
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