Non-β-lactam inhibitors of β-lactamases are provided. In particular, the invention provides such inhibitors which are phenylboronic acids I [R1 = N-lower alkyl, (un)substituted (hetero)cyclic alkene] or a pharmaceutically acceptable salt thereof. These compds. may be used with β-lactam antibiotics to treat β-lactam-antibiotic-resistant bacterial infections. Finally, the invention provides a pharmaceutical compn. comprising these compds.
Phenylboronic acid derivative inhibitors of β-lactamases, their preparation, pharmaceutical compositions, and therapeutic use / Shoichet, B K; Costi, Maria Paola; Tondi, Donatella. - (1999 Dec 16).
Phenylboronic acid derivative inhibitors of β-lactamases, their preparation, pharmaceutical compositions, and therapeutic use
costi, Maria Paola;tondi, Donatella
1999
Abstract
Non-β-lactam inhibitors of β-lactamases are provided. In particular, the invention provides such inhibitors which are phenylboronic acids I [R1 = N-lower alkyl, (un)substituted (hetero)cyclic alkene] or a pharmaceutically acceptable salt thereof. These compds. may be used with β-lactam antibiotics to treat β-lactam-antibiotic-resistant bacterial infections. Finally, the invention provides a pharmaceutical compn. comprising these compds.
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