Non-β-lactam inhibitors of β-lactamases are provided.  In particular, the invention provides such inhibitors which are aminophenylboronic acid derivs. I [R1 = (un)substituted lower alkyl, (un)substituted (hetero)cyclic alkene; Z = bond, O, S, lower (hetero)alkyl], or a pharmaceutically acceptable salt thereof.  These compds. may be used with β-lactam antibiotics to treat β-lactam-antibiotic-resistant bacterial infections.  Finally, the invention provides a pharmaceutical compn. comprising these compds.

3-Aminophenylboronic acid derivative inhibitors of β-lactamases, their preparation, and their therapeutic use / Shoichet, B. K.; Costi, Maria Paola; Tondi, Donatella. - ELETTRONICO. - (2000 Jun 22).

3-Aminophenylboronic acid derivative inhibitors of β-lactamases, their preparation, and their therapeutic use

COSTI, Maria Paola;TONDI, Donatella
2000

Abstract

Non-β-lactam inhibitors of β-lactamases are provided.  In particular, the invention provides such inhibitors which are aminophenylboronic acid derivs. I [R1 = (un)substituted lower alkyl, (un)substituted (hetero)cyclic alkene; Z = bond, O, S, lower (hetero)alkyl], or a pharmaceutically acceptable salt thereof.  These compds. may be used with β-lactam antibiotics to treat β-lactam-antibiotic-resistant bacterial infections.  Finally, the invention provides a pharmaceutical compn. comprising these compds.
22-giu-2000
Northwestern University, USA; Universita Degli Studi Di Modena E Reggio Emilia
WO 2000035905
Internazionale
Shoichet, B. K.; Costi, Maria Paola; Tondi, Donatella
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/21569
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