RASTELLI, Giulio
 Distribuzione geografica
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Continente #
NA - Nord America 24.433
AS - Asia 9.778
EU - Europa 9.158
SA - Sud America 1.535
Continente sconosciuto - Info sul continente non disponibili 344
AF - Africa 238
OC - Oceania 59
Totale 45.545
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Nazione #
US - Stati Uniti d'America 23.809
SG - Singapore 3.007
GB - Regno Unito 2.605
CN - Cina 2.576
IT - Italia 1.836
BR - Brasile 1.185
HK - Hong Kong 1.158
VN - Vietnam 1.103
SE - Svezia 976
DE - Germania 943
FI - Finlandia 504
BD - Bangladesh 454
RU - Federazione Russa 437
UA - Ucraina 388
PL - Polonia 366
FR - Francia 296
CA - Canada 291
TR - Turchia 265
KR - Corea 259
IN - India 231
ID - Indonesia 176
BG - Bulgaria 164
NL - Olanda 150
AR - Argentina 122
MX - Messico 107
ES - Italia 100
JP - Giappone 79
IQ - Iraq 71
BE - Belgio 67
IE - Irlanda 64
LT - Lituania 56
AU - Australia 55
ZA - Sudafrica 55
EC - Ecuador 52
PK - Pakistan 52
CO - Colombia 50
AE - Emirati Arabi Uniti 43
AT - Austria 39
VE - Venezuela 39
CR - Costa Rica 38
CL - Cile 34
GT - Guatemala 34
UZ - Uzbekistan 34
MA - Marocco 33
HN - Honduras 29
EG - Egitto 28
SA - Arabia Saudita 27
IR - Iran 26
PH - Filippine 26
TT - Trinidad e Tobago 23
RO - Romania 22
CH - Svizzera 21
KE - Kenya 21
IL - Israele 20
JO - Giordania 20
MY - Malesia 20
PR - Porto Rico 20
SC - Seychelles 18
TN - Tunisia 17
UY - Uruguay 17
AZ - Azerbaigian 16
JM - Giamaica 16
DO - Repubblica Dominicana 15
PY - Paraguay 15
SV - El Salvador 14
TH - Thailandia 14
DZ - Algeria 13
KZ - Kazakistan 13
NP - Nepal 13
NI - Nicaragua 12
PT - Portogallo 12
HU - Ungheria 11
AL - Albania 10
CI - Costa d'Avorio 10
RS - Serbia 10
BO - Bolivia 9
BY - Bielorussia 9
HR - Croazia 9
NG - Nigeria 9
NO - Norvegia 9
PE - Perù 9
SK - Slovacchia (Repubblica Slovacca) 9
TW - Taiwan 9
ET - Etiopia 8
GP - Guadalupe 8
GR - Grecia 8
KH - Cambogia 8
LK - Sri Lanka 8
OM - Oman 8
SN - Senegal 8
CZ - Repubblica Ceca 7
EU - Europa 7
AO - Angola 6
EE - Estonia 6
LB - Libano 6
PA - Panama 6
BB - Barbados 5
BH - Bahrain 5
CY - Cipro 5
DK - Danimarca 5
Totale 45.138
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Città #
Ashburn 3.016
Fairfield 2.304
Santa Clara 1.973
Southend 1.675
Singapore 1.608
Woodbridge 1.292
Hong Kong 1.127
Houston 1.032
Chandler 996
Seattle 924
San Jose 904
Hefei 865
Council Bluffs 839
Cambridge 804
Wilmington 742
Jacksonville 738
Ann Arbor 602
Nyköping 567
Dearborn 558
London 486
Beijing 464
Helsinki 359
Ho Chi Minh City 354
Warsaw 349
Los Angeles 342
Hanoi 265
Modena 255
The Dalles 242
Seoul 238
Milan 231
Chicago 230
New York 230
Dallas 204
San Diego 192
Princeton 171
Sofia 155
Munich 143
Eugene 132
Lauterbourg 121
Berlin 118
Izmir 115
São Paulo 115
Jakarta 114
Buffalo 112
Des Moines 103
Bologna 102
Shanghai 94
Frankfurt am Main 90
Salt Lake City 86
Boardman 85
Moscow 78
Columbus 73
Orem 73
Rome 72
Phoenix 67
Toronto 64
Tokyo 63
Washington 59
Brussels 58
Dublin 54
Atlanta 52
Mexico City 49
Porto Alegre 44
Tampa 43
Da Nang 42
Amsterdam 41
Brooklyn 41
Reggio Emilia 41
Chennai 40
Denver 40
Guangzhou 40
Haiphong 40
Norfolk 40
Redwood City 39
Bremen 38
Elk Grove Village 38
Kent 36
Naples 35
North Bergen 35
Falls Church 34
Montreal 34
Rio de Janeiro 33
Groningen 32
San José 32
Miano 30
North Charleston 29
Parma 29
Saint Augustine 29
Tashkent 29
Guatemala City 28
Norwalk 28
San Francisco 28
Baghdad 27
Nuremberg 27
Biên Hòa 26
Paris 26
Johannesburg 25
Boston 24
Las Vegas 24
Belo Horizonte 23
Totale 30.895
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Nome #
The 1,2,3-triazole ring as a bioisostere in medicinal chemistry 1.374
Polypharmacology: challenges and opportunities in drug discovery 556
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors 503
7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study 467
Structural models and binding site prediction of the C-terminal domain of human Hsp90: a new target for anticancer drugs 450
Analytical and Simulation-Based Models for Drug Release and Gel-Degradation in a Tetra-PEG Hydrogel Drug-Delivery System 413
An unexpected reversal in the pharmacological stereoselectivity of benzothiadiazine AMPA positive allosteric modulators 408
BEAR, a Molecular Docking Refinement and Rescoring Method 402
Application of a post-docking procedure based on MM-PBSA and MM-GBSA on single and multiple protein conformations 398
A rational approach to the design of flavones as xanthine oxidase inhibitors 397
Synthesis and biological activities of novel 17-aminogeldanamycin derivatives 397
Molecular docking: Shifting paradigms in drug discovery 396
Aldose reductase does catalyse the reduction of glyceraldehyde through a stoichiometric oxidation of NADPH. 387
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 364
Fast and accurate predictions of relative binding free energies using MM-PBSA and MM-GBSA 361
A model of the interaction of substrates and inhibitors with xanthine oxidase 359
Fruits of ribes, rubus, vaccinium and prunus genus. Metal contents and genome 359
New aldose reductase inhibitors as potential agents for the prevention of long-term diabetic complications 359
Role of bifidobacteria in the hydrolysis of chlorogenic acid 359
Structure-Based Design of Potent Aromatase Inhibitors by High-Throughput Docking 358
Advances and applications of binding affinity prediction methods in drug discovery 356
A computational workflow for the design of irreversible inhibitors of protein kinases 355
Antifungal Activity and DNA Topoisomerase Inhibition of Hydrolysable Tannins from Punica granatum L. 352
Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors 350
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 350
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 349
Activity of polyphenolic crude extracts as scavengers of superoxide radicals and inhibitors of xanthine oxidase 348
Activity prediction and structural insights of Extracellular Signal-Regulated Kinase 2 inhibitors with molecular dynamics simulations 345
Binding of 1-benzopyran-4-one derivatives to aldose reductase: A free energy perturbation study 345
BEAR, a novel virtual screening methodology for drug discovery 340
Molecular dynamics simulations and classical multidimensional scaling unveil new metastable states in the conformational landscape of CDK2 339
On the integration of in silico drug design methods for drug repurposing 338
Valutazione tossicologica di due nuovi inibitori della DHFR del P. falciparum e del P. vivax 336
Grid-enabled high throughput virtual screening 335
WISDOM-II: Screening against multiple targets implicated in malaria using computational grid infrastructures 329
Identification of small-molecule EGFR allosteric inhibitors by high-Throughput docking 328
Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs) 326
Selection of protein conformations for structure-based polypharmacology studies 324
Theoretical analysis of the addition of hydroxylamine to uracil and 5-fluorouracil as a model for the Thymidylate synthase reaction 322
Binding estimation after refinement, a new automated procedure for the refinement and rescoring of docked ligands in virtual screening 321
Virtual screening on large scale grids 316
Structure-based design of an inhibitor modeled at the substrate active site of aldose reductase 313
Identification of Target Associations for Polypharmacology from Analysis of Crystallographic Ligands of the Protein Data Bank 313
A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors 312
Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches 312
Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: Discovery and computational modeling of a new series of ligands with nanomolar affinity 312
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors 308
Drug Repurposing and Polypharmacology to Fight SARS-CoV-2 Through Inhibition of the Main Protease 304
Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding 303
Heat shock protein 90 and serine/threonine kinase B-Raf inhibitors have overlapping chemical space 301
Fruit of ribes, rubus, vaccinium and prunus genus, metals content and genome 298
Structural bases for the inhibition of aldose reductase by phenolic compounds 297
Enrichment Factor Analyses on G-Protein Coupled Receptors with Known Crystal Structure 295
αC helix displacement as a general approach for allosteric modulation of protein kinases 293
Exploration and Comparison of the Geometrical and Physicochemical Properties of an αc Allosteric Pocket in the Structural Kinome 291
Nitrophenyl derivatives as Aldose Reductase inhibitors 290
Identification of 4-aryl-1H-pyrrole[2,3-b]pyridine derivatives for the development of new B-Raf inhibitors 290
Computational polypharmacology analysis of the heat shock protein 90 interactome 289
In vitro effects of Plasmodium falciparum dihydrofolate reductase inhibitors on normal and cancer cell proliferation 288
Structure-based discovery of the first allosteric inhibitors of cyclin-dependent kinase 2 288
Preparation of thieno[3,2-h]cinnolinones as matrix metalloproteinase inhibitors 286
Histone deacetylases: Structural determinants of inhibitor selectivity 286
Pharmacological approaches to the treatment of diabetic complications 285
Discovery of new inhibitors of aldose reductase from molecular docking and database screening 285
Structure–Activity Relationships of Hexahydrocyclopenta[c]quinoline Derivatives as Allosteric Inhibitors of CDK2 and EGFR 285
Exploring the binding site of C-terminal Hsp90 inhibitors 284
Quantitative measurement of proton dissociation and tautomeric constants of apigeninidin 284
Structure of Plasmodium vivax dihydrofolate reductase determined by homology modeling and molecular dynamics refinement 283
ANTHOCYANIDINES AS INHIBITORS OF XANTHINE-OXIDASE 283
Investigating the Selectivity of Allosteric Inhibitors for Mutant T790M EGFR over Wild Type Using Molecular Dynamics and Binding Free Energy Calculations 283
Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 282
Prediction of activity and selectivity profiles of human Carbonic Anhydrase inhibitors using machine learning classification models 281
Composition, Superoxide Radicals Scavenging and Antilipoperoxidant Activity of some Edible Fruits 279
Physico-chemical properties of anthocyanidins. Part 1. Theoretical evaluation of the stability of the neutral and anionic tautomeric forms 277
Conformational analysis, molecular modeling and quantitative structure-activity relationships studies of 2,4-diamino-6,7-dimethoxy-2-substituted quinazoline α1-adrenergic antagonists 277
Design and discovery of plasmepsin inhibitors using an automated workflow on large scale grids 276
Structure-based design of 7-carbamate analogs of geldanamycin 276
Promiscuity of inhibitors of human protein kinases at varying data confidence levels and test frequencies 275
Novel and less explored chemotypes of natural origin for the inhibition of Hsp90 273
Model chemical studies of thymidylate synthase. Nucleophilic addition of hydroxylamine to uracil and 5-fluorouracil 272
Molecular modeling and crystal structure of ERK2-Hypothemycin complexes 272
Oxidative modification of aldose reductase induced by copper ion. Factors and conditions affecting the process 271
Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity contants of variously hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition 270
Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: Structural basis of antifolate resistance 268
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer 267
Targeting the Hsp90 interactome using in silico polypharmacology approaches 265
Design of dual inhibitors of histone deacetylase 6 and heat shock protein 90 265
Activité Antilipoperoxydante d'Extraits Polyphenoliques de Ribes Nigrum L. 264
Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach 264
Assessing protein kinase selectivity with molecular dynamics and MM-PBSA binding free energy calculations. 264
Ortho-halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity 264
Insight into the specificity of Thymidylate synthase from molecular dynamics and free-energy perturbation calculations 261
Solvent effects on the tautomerism of apigeninidin 258
Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors 255
Improving enrichment and hit rate in virtual screening 253
QSAR analysis in 2,4-diamino-6,7-dimethoxy quinoline derivatives - α1-adrenoceptor antagonists - using the partial least squares (PLS) method and theoretical molecular descriptors 252
Computational polypharmacology comes of age 251
LigAdvisor: A versatile and user-friendly web-platform for drug design 251
Structure-based and in silico design of Hsp90 inhibitors 250
Theoretical and experimental study of flavones as inhibitors of xanthine oxidase 250
Totale 32.695
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Categoria #
all - tutte 170.964
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 170.964
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.994 0 0 0 0 72 146 209 167 296 254 527 323
2022/20232.952 396 372 215 229 317 435 79 267 399 48 138 57
2023/20241.863 62 121 126 154 427 144 159 314 36 41 79 200
2024/20257.333 254 66 120 499 1.288 953 367 627 683 800 775 901
2025/202613.033 806 665 1.210 1.486 1.525 1.187 1.385 644 1.268 1.291 928 638
2026/20274.361 458 823 947 1.810 323 0 0 0 0 0 0 0
Totale 45.545