Novel and less explored chemotypes of natural origin for the inhibition of Hsp90

Pellati, Federica; Rastelli, Giulio

doi:10.1039/c6md00340k

The Hsp90 chaperone is a promising target for the treatment of cancer. Well known inhibitors, e.g. geldanamycin, radicicol, novobiocin and their derivatives, have been extensively investigated and optimized as inhibitors of Hsp90. More recently, new chemotypes of natural origin were reported to modulate Hsp90 function via various and often “non-conventional” mechanisms. This review focuses on these novel classes of natural products whose structures have not yet been thoroughly explored for medicinal chemistry purposes. These novel chemotypes may constitute interesting starting points for future drug discovery campaigns.

Novel and less explored chemotypes of natural origin for the inhibition of Hsp90 / Pellati, Federica; Rastelli, Giulio. - In: MEDCHEMCOMM. - ISSN 2040-2503. - STAMPA. - 7(2016), pp. 2063-2075.

Data di pubblicazione:	2016
Titolo:	Novel and less explored chemotypes of natural origin for the inhibition of Hsp90
Autore/i:	Pellati, Federica; Rastelli, Giulio
Autore/i UNIMORE:	PELLATI, Federica RASTELLI, Giulio
Digital Object Identifier (DOI):	http://dx.doi.org/10.1039/c6md00340k
Rivista:	MEDCHEMCOMM
Volume:	7
Pagina iniziale:	2063
Pagina finale:	2075
Codice identificativo ISI:	WOS:000390551700002
Codice identificativo Scopus:	2-s2.0-84994480336
Citazione:	Novel and less explored chemotypes of natural origin for the inhibition of Hsp90 / Pellati, Federica; Rastelli, Giulio. - In: MEDCHEMCOMM. - ISSN 2040-2503. - STAMPA. - 7(2016), pp. 2063-2075.
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Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11380/1111528

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