Toxicological evaluations were performed on two novel Plasmodium falciparum dihydrofolate reductase inhibitors and other known antimalarial drugs. Cytotoxicity tests were performed on Vero and MCF-7 cells and apoptotic and/or proliferative markers p21 and p53 and A, B1, D1, and D2 cyclines. The results are discussed and show that this molecule can be considered an interesting new candidate for further development.
In vitro effects of Plasmodium falciparum dihydrofolate reductase inhibitors on normal and cancer cell proliferation / Rossi, Tiziana; Coppi, A; Bruni, E; Sgobba, Miriam; Degliesposti, Gianluca; Rastelli, Giulio. - In: CHEMMEDCHEM. - ISSN 1860-7179. - STAMPA. - 3:(2008), pp. 421-424. [10.1002/cmdc.200700257]
In vitro effects of Plasmodium falciparum dihydrofolate reductase inhibitors on normal and cancer cell proliferation
ROSSI, Tiziana;SGOBBA, Miriam;DEGLIESPOSTI, Gianluca;RASTELLI, Giulio
2008
Abstract
Toxicological evaluations were performed on two novel Plasmodium falciparum dihydrofolate reductase inhibitors and other known antimalarial drugs. Cytotoxicity tests were performed on Vero and MCF-7 cells and apoptotic and/or proliferative markers p21 and p53 and A, B1, D1, and D2 cyclines. The results are discussed and show that this molecule can be considered an interesting new candidate for further development.
| File | Dimensione | Formato | |
|---|---|---|---|
|
TRossi-GRastelli-DHFRtoxicology.pdf
Accesso riservato
Tipologia:
Versione pubblicata dall'editore
Dimensione
284.84 kB
Formato
Adobe PDF
|
284.84 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
