Toxicological evaluations were performed on two novel Plasmodium falciparum dihydrofolate reductase inhibitors and other known antimalarial drugs. Cytotoxicity tests were performed on Vero and MCF-7 cells and apoptotic and/or proliferative markers p21 and p53 and A, B1, D1, and D2 cyclines. The results are discussed and show that this molecule can be considered an interesting new candidate for further development.
In vitro effects of Plasmodium falciparum dihydrofolate reductase inhibitors on normal and cancer cell proliferation / Rossi, Tiziana; Coppi, A; Bruni, E; Sgobba, Miriam; Degliesposti, Gianluca; Rastelli, Giulio. - In: CHEMMEDCHEM. - ISSN 1860-7179. - STAMPA. - 3:3(2008), pp. 421-424. [10.1002/cmdc.200700257]
In vitro effects of Plasmodium falciparum dihydrofolate reductase inhibitors on normal and cancer cell proliferation
ROSSI, Tiziana;SGOBBA, Miriam;DEGLIESPOSTI, Gianluca;RASTELLI, Giulio
2008
Abstract
Toxicological evaluations were performed on two novel Plasmodium falciparum dihydrofolate reductase inhibitors and other known antimalarial drugs. Cytotoxicity tests were performed on Vero and MCF-7 cells and apoptotic and/or proliferative markers p21 and p53 and A, B1, D1, and D2 cyclines. The results are discussed and show that this molecule can be considered an interesting new candidate for further development.
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