The 90 kDa heat shock protein (Hsp90) is a prominent target for anticancer drug discovery. While its N-terminal domain has been widely exploited, several lines of evidence are emerging in favor of targeting its C-terminal domain to conceive innovative drugs based on perturbation of the dimer interface. Here, we describe the application of several computational approaches useful to predict the location of the C-terminal binding site.

Exploring the binding site of C-terminal Hsp90 inhibitors / Sgobba, Miriam; Forestiero, Rosetta; Degliesposti, Gianluca; Rastelli, Giulio. - In: JOURNAL OF CHEMICAL INFORMATION AND MODELING. - ISSN 1549-9596. - STAMPA. - 50:(2010), pp. 1522-1528. [10.1021/ci1001857]

Exploring the binding site of C-terminal Hsp90 inhibitors

SGOBBA, Miriam;FORESTIERO, ROSETTA;DEGLIESPOSTI, Gianluca;RASTELLI, Giulio
2010-01-01

Abstract

The 90 kDa heat shock protein (Hsp90) is a prominent target for anticancer drug discovery. While its N-terminal domain has been widely exploited, several lines of evidence are emerging in favor of targeting its C-terminal domain to conceive innovative drugs based on perturbation of the dimer interface. Here, we describe the application of several computational approaches useful to predict the location of the C-terminal binding site.
50
1522
1528
Exploring the binding site of C-terminal Hsp90 inhibitors / Sgobba, Miriam; Forestiero, Rosetta; Degliesposti, Gianluca; Rastelli, Giulio. - In: JOURNAL OF CHEMICAL INFORMATION AND MODELING. - ISSN 1549-9596. - STAMPA. - 50:(2010), pp. 1522-1528. [10.1021/ci1001857]
Sgobba, Miriam; Forestiero, Rosetta; Degliesposti, Gianluca; Rastelli, Giulio
File in questo prodotto:
File Dimensione Formato  
CTHsp90_Rastelli_JCIM_2010.pdf

non disponibili

Tipologia: Versione pubblicata dall'editore
Dimensione 3.88 MB
Formato Adobe PDF
3.88 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/684292
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 25
social impact