During the last years, a significant interest in the identification of new classes of B-Raf inhibitors has emerged. In this study, which was conceived within an effort that culminated in the recent report of the first dual inhibitors of B-Raf and Hsp90, we describe the identification of four compounds based on 4-aryl-1H-pyrrole[2,3-b]pyridine scaffold as interesting starting points for the development of new B-Raf inhibitors. Structure-activity relationships and predicted binding modes are discussed. Moreover, the novelty of the newly identified structures with respect to currently known B-Raf inhibitors was assessed through a ligand-based dissimilarity assessment. Finally, structural modifications with the potential ability to improve the activity toward B-Raf are put forward. This article is protected by copyright. All rights reserved.

Identification of 4-aryl-1H-pyrrole[2,3-b]pyridine derivatives for the development of new B-Raf inhibitors / Pinzi, Luca; Anighoro, Andrew; Bajorath, Jürgen; Rastelli, Giulio. - In: CHEMICAL BIOLOGY & DRUG DESIGN. - ISSN 1747-0277. - 92:1(2018), pp. 1382-1386. [10.1111/cbdd.13185]

Identification of 4-aryl-1H-pyrrole[2,3-b]pyridine derivatives for the development of new B-Raf inhibitors

Pinzi, Luca;Anighoro, Andrew;Rastelli, Giulio
2018

Abstract

During the last years, a significant interest in the identification of new classes of B-Raf inhibitors has emerged. In this study, which was conceived within an effort that culminated in the recent report of the first dual inhibitors of B-Raf and Hsp90, we describe the identification of four compounds based on 4-aryl-1H-pyrrole[2,3-b]pyridine scaffold as interesting starting points for the development of new B-Raf inhibitors. Structure-activity relationships and predicted binding modes are discussed. Moreover, the novelty of the newly identified structures with respect to currently known B-Raf inhibitors was assessed through a ligand-based dissimilarity assessment. Finally, structural modifications with the potential ability to improve the activity toward B-Raf are put forward. This article is protected by copyright. All rights reserved.
8-mar-2018
92
1
1382
1386
Identification of 4-aryl-1H-pyrrole[2,3-b]pyridine derivatives for the development of new B-Raf inhibitors / Pinzi, Luca; Anighoro, Andrew; Bajorath, Jürgen; Rastelli, Giulio. - In: CHEMICAL BIOLOGY & DRUG DESIGN. - ISSN 1747-0277. - 92:1(2018), pp. 1382-1386. [10.1111/cbdd.13185]
Pinzi, Luca; Anighoro, Andrew; Bajorath, Jürgen; Rastelli, Giulio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1154426
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