During the last years, a significant interest in the identification of new classes of B-Raf inhibitors has emerged. In this study, which was conceived within an effort that culminated in the recent report of the first dual inhibitors of B-Raf and Hsp90, we describe the identification of four compounds based on 4-aryl-1H-pyrrole[2,3-b]pyridine scaffold as interesting starting points for the development of new B-Raf inhibitors. Structure-activity relationships and predicted binding modes are discussed. Moreover, the novelty of the newly identified structures with respect to currently known B-Raf inhibitors was assessed through a ligand-based dissimilarity assessment. Finally, structural modifications with the potential ability to improve the activity toward B-Raf are put forward. This article is protected by copyright. All rights reserved.
Identification of 4-aryl-1H-pyrrole[2,3-b]pyridine derivatives for the development of new B-Raf inhibitors / Pinzi, Luca; Anighoro, Andrew; Bajorath, Jürgen; Rastelli, Giulio. - In: CHEMICAL BIOLOGY & DRUG DESIGN. - ISSN 1747-0277. - 92:1(2018), pp. 1382-1386.
Data di pubblicazione: | 2018 |
Data di prima pubblicazione: | 8-mar-2018 |
Titolo: | Identification of 4-aryl-1H-pyrrole[2,3-b]pyridine derivatives for the development of new B-Raf inhibitors |
Autore/i: | Pinzi, Luca; Anighoro, Andrew; Bajorath, Jürgen; Rastelli, Giulio |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/cbdd.13185 |
Rivista: | |
Volume: | 92 |
Fascicolo: | 1 |
Pagina iniziale: | 1382 |
Pagina finale: | 1386 |
Codice identificativo ISI: | WOS:000436403500021 |
Codice identificativo Scopus: | 2-s2.0-85043371456 |
Codice identificativo Pubmed: | 29469983 |
Citazione: | Identification of 4-aryl-1H-pyrrole[2,3-b]pyridine derivatives for the development of new B-Raf inhibitors / Pinzi, Luca; Anighoro, Andrew; Bajorath, Jürgen; Rastelli, Giulio. - In: CHEMICAL BIOLOGY & DRUG DESIGN. - ISSN 1747-0277. - 92:1(2018), pp. 1382-1386. |
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