EnglishIn the course of our research aimed at the discovery of new compounds acting as aldose reductase inhibitors, we tested a series of some (E)- and (Z)-ω-[[(aryldiazinylmethylene)amino]oxy]alkanoic acids, which were found to have moderate in vitro inhibitory activity. On this basis we have now prepared several new derivatives modified both at the length of the chain and at its terminal carboxylic group, together with compounds carrying various substituents at the phenyl ring. This paper describes their synthesis and biological properties.
A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors / D., Rakowitz; G., Heinisch; P., Lukavsky; S., Kiendler; C., Trenkwalder; D., Barlocco; Rastelli, Giulio; Costantino, Luca. - In: JOURNAL OF HETEROCYCLIC CHEMISTRY. - ISSN 0022-152X. - STAMPA. - 37(2000), pp. 1089-1096. [10.1002/jhet.5570370511]
| Data di pubblicazione: | 2000 | |
| Titolo: | A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors | |
| Autore/i: | D., Rakowitz; G., Heinisch; P., Lukavsky; S., Kiendler; C., Trenkwalder; D., Barlocco; Rastelli, Giulio; Costantino, Luca | |
| Autore/i UNIMORE: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/jhet.5570370511 | |
| Rivista: | ||
| Volume: | 37 | |
| Pagina iniziale: | 1089 | |
| Pagina finale: | 1096 | |
| Codice identificativo ISI: | WOS:000165229300011 | |
| Codice identificativo Scopus: | 2-s2.0-0033763018 | |
| Citazione: | A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors / D., Rakowitz; G., Heinisch; P., Lukavsky; S., Kiendler; C., Trenkwalder; D., Barlocco; Rastelli, Giulio; Costantino, Luca. - In: JOURNAL OF HETEROCYCLIC CHEMISTRY. - ISSN 0022-152X. - STAMPA. - 37(2000), pp. 1089-1096. [10.1002/jhet.5570370511] | |
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