A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors

Rakowitz, D.; Heinisch, G.; Lukavsky, P.; Kiendler, S.; Trenkwalder, C.; Barlocco, D.; Rastelli, Giulio; Costantino, Luca

doi:10.1002/jhet.5570370511

In the course of our research aimed at the discovery of new compounds acting as aldose reductase inhibitors, we tested a series of some (E)- and (Z)-ω-[[(aryldiazinylmethylene)amino]oxy]alkanoic acids, which were found to have moderate in vitro inhibitory activity. On this basis we have now prepared several new derivatives modified both at the length of the chain and at its terminal carboxylic group, together with compounds carrying various substituents at the phenyl ring. This paper describes their synthesis and biological properties.

A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors / D., Rakowitz; G., Heinisch; P., Lukavsky; S., Kiendler; C., Trenkwalder; D., Barlocco; Rastelli, Giulio; Costantino, Luca. - In: JOURNAL OF HETEROCYCLIC CHEMISTRY. - ISSN 0022-152X. - STAMPA. - 37(2000), pp. 1089-1096.

Data di pubblicazione:	2000
Titolo:	A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors
Autore/i:	D., Rakowitz; G., Heinisch; P., Lukavsky; S., Kiendler; C., Trenkwalder; D., Barlocco; Rastelli, Giulio; Costantino, Luca
Autore/i UNIMORE:	D. RAKOWITZ G. HEINISCH P. LUKAVSKY S. KIENDLER C. TRENKWALDER D. BARLOCCO RASTELLI, Giulio COSTANTINO, Luca mostra contributor esterni nascondi contributor esterni
Digital Object Identifier (DOI):	http://dx.doi.org/10.1002/jhet.5570370511
Rivista:	JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume:	37
Pagina iniziale:	1089
Pagina finale:	1096
Codice identificativo ISI:	WOS:000165229300011
Codice identificativo Scopus:	2-s2.0-0033763018
Citazione:	A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors / D., Rakowitz; G., Heinisch; P., Lukavsky; S., Kiendler; C., Trenkwalder; D., Barlocco; Rastelli, Giulio; Costantino, Luca. - In: JOURNAL OF HETEROCYCLIC CHEMISTRY. - ISSN 0022-152X. - STAMPA. - 37(2000), pp. 1089-1096.
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