The molecular chaperone Hsp90 is responsible for activation and stabilization of several oncoproteins in cancer cells, and has emerged as an important target in cancer treatment because of this pivotal role. In recent years, interests have arisen around structure-based design of small molecules aimed at inhibiting the chaperone activity of Hsp90. In this review, we illustrate the recent advances in structure-based and in silico strategies aimed at discovering and optimizing Hsp90 inhibitors.

Structure-based and in silico design of Hsp90 inhibitors / M., Sgobba; Rastelli, Giulio. - In: CHEMMEDCHEM. - ISSN 1860-7179. - STAMPA. - 4:(2009), pp. 1399-1409. [10.1002/cmdc.200900256]

Structure-based and in silico design of Hsp90 inhibitors

RASTELLI, Giulio
2009

Abstract

The molecular chaperone Hsp90 is responsible for activation and stabilization of several oncoproteins in cancer cells, and has emerged as an important target in cancer treatment because of this pivotal role. In recent years, interests have arisen around structure-based design of small molecules aimed at inhibiting the chaperone activity of Hsp90. In this review, we illustrate the recent advances in structure-based and in silico strategies aimed at discovering and optimizing Hsp90 inhibitors.
2009
4
1399
1409
Structure-based and in silico design of Hsp90 inhibitors / M., Sgobba; Rastelli, Giulio. - In: CHEMMEDCHEM. - ISSN 1860-7179. - STAMPA. - 4:(2009), pp. 1399-1409. [10.1002/cmdc.200900256]
M., Sgobba; Rastelli, Giulio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/641852
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