1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of new active molecules. Here, we provide an overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.

The 1,2,3-triazole ring as a bioisostere in medicinal chemistry / Bonandi, Elisa; Christodoulou, Michael S.; Fumagalli, Gaia; Perdicchia, Dario; Rastelli, Giulio; Passarella, Daniele. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 22:10(2017), pp. 1572-1581. [10.1016/j.drudis.2017.05.014]

The 1,2,3-triazole ring as a bioisostere in medicinal chemistry

Rastelli, Giulio;
2017

Abstract

1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of new active molecules. Here, we provide an overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.
1-lug-2017
22
10
1572
1581
The 1,2,3-triazole ring as a bioisostere in medicinal chemistry / Bonandi, Elisa; Christodoulou, Michael S.; Fumagalli, Gaia; Perdicchia, Dario; Rastelli, Giulio; Passarella, Daniele. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 22:10(2017), pp. 1572-1581. [10.1016/j.drudis.2017.05.014]
Bonandi, Elisa; Christodoulou, Michael S.; Fumagalli, Gaia; Perdicchia, Dario; Rastelli, Giulio; Passarella, Daniele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1153568
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