COSTANTINO, Luca
 Distribuzione geografica
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Continente #
NA - Nord America 14.538
EU - Europa 6.813
AS - Asia 1.951
AF - Africa 40
SA - Sud America 37
OC - Oceania 18
Continente sconosciuto - Info sul continente non disponibili 11
Totale 23.408
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Nazione #
US - Stati Uniti d'America 14.498
GB - Regno Unito 2.664
IT - Italia 1.178
SE - Svezia 918
CN - Cina 703
DE - Germania 681
UA - Ucraina 443
SG - Singapore 367
TR - Turchia 328
HK - Hong Kong 304
FI - Finlandia 233
FR - Francia 179
BG - Bulgaria 174
IN - India 83
RU - Federazione Russa 62
KR - Corea 46
IE - Irlanda 40
BE - Belgio 39
CH - Svizzera 31
CA - Canada 30
NL - Olanda 30
BR - Brasile 29
PL - Polonia 29
ID - Indonesia 27
JP - Giappone 23
RO - Romania 23
IR - Iran 20
ES - Italia 19
ZA - Sudafrica 17
AU - Australia 15
LT - Lituania 13
CZ - Repubblica Ceca 12
PT - Portogallo 12
EU - Europa 11
BD - Bangladesh 10
EG - Egitto 7
AT - Austria 6
GR - Grecia 6
MX - Messico 6
TW - Taiwan 6
VN - Vietnam 6
MY - Malesia 5
PK - Pakistan 5
BZ - Belize 4
CL - Cile 4
IQ - Iraq 4
MD - Moldavia 4
NO - Norvegia 4
SN - Senegal 4
BY - Bielorussia 3
MA - Marocco 3
NG - Nigeria 3
NZ - Nuova Zelanda 3
RS - Serbia 3
TZ - Tanzania 3
AE - Emirati Arabi Uniti 2
AR - Argentina 2
DK - Danimarca 2
DZ - Algeria 2
HU - Ungheria 2
IL - Israele 2
LK - Sri Lanka 2
PH - Filippine 2
TH - Thailandia 2
VE - Venezuela 2
AL - Albania 1
CM - Camerun 1
HR - Croazia 1
JO - Giordania 1
KH - Cambogia 1
MO - Macao, regione amministrativa speciale della Cina 1
NP - Nepal 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 23.408
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Città #
Southend 2.220
Fairfield 2.116
Woodbridge 1.451
Ashburn 1.135
Chandler 1.119
Houston 1.004
Jacksonville 934
Seattle 934
Ann Arbor 788
Wilmington 783
Dearborn 751
Cambridge 741
Nyköping 559
Hong Kong 298
Singapore 258
Beijing 244
Modena 217
Izmir 202
San Diego 201
Princeton 198
Sofia 169
Eugene 166
Bremen 125
Frankfurt am Main 101
Redwood City 98
Helsinki 88
New York 76
Des Moines 69
Shanghai 60
Milan 55
London 54
Fremont 48
Rome 44
Chicago 41
Bologna 39
Dublin 39
Verona 36
Boardman 33
Hefei 33
Nanjing 32
Norwalk 30
Napoli 26
Brussels 25
Parma 24
Guangzhou 22
Kunming 22
Kraków 19
Los Angeles 19
Philadelphia 18
Falls Church 17
Saint Petersburg 17
San Mateo 17
Jinan 16
Sassuolo 16
Auburn Hills 15
Chiswick 15
Kilburn 14
Cape Town 13
Naples 13
Ottawa 12
Tokyo 12
Brno 11
Hounslow 11
Reggio Nell'emilia 11
Basel 10
Carmichael 10
Ferrara 10
Indiana 10
Jakarta 10
San Francisco 10
Fuzhou 9
Nanchang 9
Negrar 9
Phoenix 9
Segrate 9
Seoul 9
Toronto 9
Wuhan 9
Grafing 8
Hangzhou 8
Leawood 8
Mumbai 8
Siena 8
Trieste 8
Augusta 7
Avellino 7
Dallas 7
New Delhi 7
Pisa 7
Washington 7
Zhengzhou 7
Chongqing 6
Deford 6
Dongguan 6
Hebei 6
Kyiv 6
Madrid 6
Mountain View 6
Porto 6
Sydney 6
Totale 18.257
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Nome #
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 317
The Impact of Lipid Corona on Rifampicin Intramacrophagic Transport Using Inhaled Solid Lipid Nanoparticles Surface-Decorated with a Mannosylated Surfactant 310
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 267
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors 259
7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study 244
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 240
Current and Future Chemotherapy for Chagas Disease 237
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 222
Laboratorio di Preparazione Estrattiva e Sintetica dei Farmaci 217
Targeting the Central Nervous System: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123 214
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 212
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 211
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 211
Synthesis and description of chalcone-like compounds, inhibitors of aldose reductase 203
Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy 202
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 201
PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid 201
ANTIINFLAMMATORY ACTIVITY OF NEWLY SYNTHESIZED 2,6-BIS-(1,1-DIMETHYLETHYL)PHENOL DERIVATIVES 198
Structure-based design of an inhibitor modeled at the substrate active site of aldose reductase 197
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent 195
Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution 194
Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors 186
New aldose reductase inhibitors as potential agents for the prevention of long-term diabetic complications 186
Colloidal systems for CNS drug delivery 183
Folate: Relevance of Chemical and Microbial Production 182
Iron acquisition pathways as targets for antitubercular drugs 180
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors 179
Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives 178
Binding of 1-benzopyran-4-one derivatives to aldose reductase: A free energy perturbation study 178
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution 174
Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier 174
Isolation and Pharmacological Activities of the Tecoma stans Alkaloids 173
ANTICANCER DRUGS 172
A rational approach to the design of flavones as xanthine oxidase inhibitors 171
Aldose reductase does catalyse the reduction of glyceraldehyde through a stoichiometric oxidation of NADPH. 169
Glycopeptide-decorated nanoparticles as drug carriers for CNS: effects of surface coverage and carbohydrate type 169
Synthesis and activity of a new series of chalcones as aldose reductase inhibitors 168
Nanoparticulate drug carriers based on hybrid poly(D,L-lactide-co-glycolide)-dendron structures 168
Anti-TB inhalation therapy: Design of mannose-based functionalised Solid Lipid Microparticles for an active targeting to alveolar macrophages 168
Quantitative measurement of proton dissociation and tautomeric constants of apigeninidin 167
Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches 166
Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase 166
Polymeric nanoparticles for the drug delivery to the central nervous system 164
Soft docking and multiple receptor conformations in virtual screening. 163
Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic? 163
Development of flavonoids derivatives as leads against Leishmaniasis and Trypanosomiasis-invited lecture 162
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 162
Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders 162
Structural bases for the inhibition of aldose reductase by phenolic compounds 161
Synthesis and aldose reductase inhibitory activity of a new series of benzo[h]cinnolinone derivatives 158
Synthesis of novel benzoic acid derivatives with benzothiazolyl subunit and evaluation as aldose reductase inhibitors 158
Molecular dynamics simulations of the structure of aldose reductase complexed with the inhibitor Tolrestat 157
Solvent effects on the tautomerism of apigeninidin 156
Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors 156
Magnetic and Optical Bistability in Tetrairon(III) Single Molecule Magnets Functionalized with Azobenzene Groups 156
Privileged structures as leads in medicinal chemistry 155
Theoretical and experimental study of flavones as inhibitors of xanthine oxidase 155
Physico-chemical properties of anthocyanidins. Part 1. Theoretical evaluation of the stability of the neutral and anionic tautomeric forms 154
Synthesis and Aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones. 153
A model of the interaction of substrates and inhibitors with xanthine oxidase 153
Interaction of nanoparticles with immunocompetent cells: nanosafety considerations. 153
Activity of polyphenolic crude extracts as scavengers of superoxide radicals and inhibitors of xanthine oxidase 152
Peptide-derivatized biodegradable nanoparticles able to cross the blood brain barrier 152
Heteroarylalkanoic acids with possible antiinflammatory activities, III 151
Discovery of new inhibitors of aldose reductase from molecular docking and database screening 151
Pharmacological approaches to the treatment of diabetic complications 150
Novel engineered lipid-based nanoparticles for pulmonary tuberculosis inhalation therapy 150
Synthesis and aldose reductase inhibitory activities of novel thienocinnolinone derivatives 149
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 148
Newly synthesized surfactants for surface mannosylation of respirable SLN assemblies to target macrophages in tuberculosis therapy 148
Oxidative modification of aldose reductase induced by copper ion. Factors and conditions affecting the process 148
Challenges in the design of clinically useful brain-targeted drug nanocarriers 147
Conjugated poly(D,L-lactide-co-glycolide) for the preparation of in vivo detectable nanoparticles 147
On the prodrug-potential of novel Aldose reductase inhibitors with diphenylmethyleneaminooxycarboxylic acid structure 146
STAT3 as Target for cancer drug discovery 146
Nitrophenyl derivatives as Aldose Reductase inhibitors 145
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 143
COMPOSTI AD ATTIVITÀ ANTIPARASSITARIA 143
Drugs/lamellae interface influences the inner structure of double-loaded liposomes for inhaled anti-TB therapy: An in-depth small-angle neutron scattering investigation 142
Small-angle neutron scattering characterization of liposomes for anti-tuberculosis inhaled therapy. 141
Free energy perturbation studies on binding of the inhibitor 5,6-dihydrobenzo[h]cinnolin-3(2H)one-2-acetic acid and its methoxylated analogs to aldose reductase 140
Thienocinnolinone alkanoic acid derivatives as aldose reductase inhibitors 138
Composition, Superoxide Radicals Scavenging and Antilipoperoxidant Activity of some Edible Fruits 137
New perspectives on the development of antiobesity drugs 137
Is there a clinical future for polymeric nanoparticles as brain targeting drug delivery agents? 136
Growth hormone secretagogue receptor antagonists 136
In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment? 136
Cell internalization study of hybrid chitosan-heparin-PLGA nanocarriers on Caco-2 cells 135
Surface decorated nanoparticles as drug delivery agents to the brain 132
Challenges in the design of multitarget drugs against multifactorial pathologies: a new life for medicinal chemistry? 130
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 130
Dottorato regionale Spinner-Nuove molecole per il controllo e la differenziazione delle cellule staminali-NovaMolStam- Università di Bologna, Ferrara, Modena e Reggio Emilia, Parma-Anno 2012-2015- 129
New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents 129
Identificazione, caratterizzazione e proprietà biologiche di derivati calconici da GLYCYRRHIZA GLABRA L. 128
Designed multiple ligands: basic research vs clinical outcomes 128
New chromane-based derivatives as inhibitors of mycobacterium tuberculosis salicylate synthase (mbti): Preliminary biological evaluation and molecular modeling studies 128
DETERMINATION OF DRUG - MACROMOLECULE BINDING PARAMETERS BY NUMERICAL-ANALYSIS 128
Attivité antifongique in vitro de l’huille essentielle de chemotypes de lavandin 125
A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors 124
Ghrelin receptor modulators and their therapeutic potential 122
Totale 16.837
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Categoria #
all - tutte 95.667
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 95.667
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20205.048 0 0 233 442 671 848 918 588 622 186 305 235
2020/20214.437 502 255 368 335 450 317 323 491 214 708 298 176
2021/20223.031 93 396 425 199 79 155 167 206 290 200 487 334
2022/20233.139 417 341 225 281 420 479 73 246 410 54 114 79
2023/20241.868 69 119 105 191 431 178 177 246 57 51 79 165
2024/2025413 287 86 40 0 0 0 0 0 0 0 0 0
Totale 23.626