COSTANTINO, Luca
 Distribuzione geografica
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Continente #
NA - Nord America 23.219
EU - Europa 9.269
AS - Asia 9.213
SA - Sud America 1.236
AF - Africa 223
OC - Oceania 31
Continente sconosciuto - Info sul continente non disponibili 12
Totale 43.203
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Nazione #
US - Stati Uniti d'America 22.897
GB - Regno Unito 3.111
SG - Singapore 2.652
CN - Cina 2.564
IT - Italia 1.744
SE - Svezia 1.044
VN - Vietnam 1.021
HK - Hong Kong 1.011
BR - Brasile 963
DE - Germania 816
UA - Ucraina 496
RU - Federazione Russa 446
BD - Bangladesh 435
FI - Finlandia 424
FR - Francia 406
TR - Turchia 393
KR - Corea 297
IN - India 248
BG - Bulgaria 178
CA - Canada 168
NL - Olanda 126
AR - Argentina 89
JP - Giappone 86
MX - Messico 85
ID - Indonesia 79
IQ - Iraq 77
ZA - Sudafrica 66
ES - Italia 62
PL - Polonia 62
IE - Irlanda 60
BE - Belgio 50
PK - Pakistan 48
EC - Ecuador 45
CH - Svizzera 39
AE - Emirati Arabi Uniti 38
CL - Cile 35
MA - Marocco 31
PH - Filippine 29
RO - Romania 29
LT - Lituania 28
AU - Australia 27
CO - Colombia 26
PY - Paraguay 25
EG - Egitto 24
VE - Venezuela 23
AT - Austria 21
PT - Portogallo 21
SA - Arabia Saudita 21
TW - Taiwan 21
IR - Iran 20
KE - Kenya 20
DZ - Algeria 19
JO - Giordania 19
MY - Malesia 18
AZ - Azerbaigian 17
MD - Moldavia 15
PE - Perù 15
TH - Thailandia 15
UZ - Uzbekistan 15
CZ - Repubblica Ceca 14
NP - Nepal 14
TN - Tunisia 13
JM - Giamaica 12
BY - Bielorussia 11
EU - Europa 11
CR - Costa Rica 10
UY - Uruguay 10
DK - Danimarca 9
GR - Grecia 9
SN - Senegal 9
IL - Israele 8
NO - Norvegia 8
DO - Repubblica Dominicana 7
GT - Guatemala 7
KZ - Kazakistan 7
LB - Libano 7
LK - Sri Lanka 7
RS - Serbia 7
AO - Angola 6
BH - Bahrain 6
EE - Estonia 6
ET - Etiopia 6
NI - Nicaragua 6
QA - Qatar 6
CI - Costa d'Avorio 5
KG - Kirghizistan 5
NG - Nigeria 5
TT - Trinidad e Tobago 5
AL - Albania 4
BO - Bolivia 4
BZ - Belize 4
GE - Georgia 4
HR - Croazia 4
HU - Ungheria 4
KW - Kuwait 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
OM - Oman 4
PA - Panama 4
PR - Porto Rico 4
Totale 43.144
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Città #
Southend 2.220
Fairfield 2.118
Ashburn 2.028
Santa Clara 1.895
Singapore 1.626
Woodbridge 1.451
Chandler 1.119
Houston 1.030
Hong Kong 994
Seattle 945
Jacksonville 941
Hefei 858
Wilmington 820
Ann Arbor 788
Dearborn 751
Cambridge 746
San Jose 729
Chicago 631
Nyköping 559
Los Angeles 469
Beijing 438
London 408
Ho Chi Minh City 319
Council Bluffs 283
Salt Lake City 264
Helsinki 261
The Dalles 256
Hanoi 248
Seoul 246
Modena 229
Izmir 207
San Diego 206
Princeton 198
New York 191
Sofia 170
Milan 167
Eugene 166
Buffalo 155
Dallas 153
Frankfurt am Main 145
Lauterbourg 136
Bremen 125
Moscow 124
Shanghai 108
Elk Grove Village 103
Redwood City 98
Tampa 92
Orem 79
Rome 78
São Paulo 76
Tokyo 70
Des Moines 69
Dublin 57
Lancaster 57
Munich 55
Sterling 53
Bologna 52
Guangzhou 49
Phoenix 49
Columbus 48
Fremont 48
Atlanta 43
Da Nang 43
Haiphong 43
Chennai 42
Verona 41
Boardman 39
Miami 38
Nanjing 37
Mexico City 35
Jakarta 34
Toronto 34
Amsterdam 33
Denver 33
Montreal 33
Parma 32
Brussels 31
Philadelphia 31
Detroit 30
Norwalk 30
Rio de Janeiro 30
Brooklyn 29
Naples 28
Baghdad 27
Jinan 27
Kunming 27
Miano 27
Mumbai 27
Napoli 26
San Francisco 25
Belo Horizonte 24
Dulles 24
New Delhi 23
Paris 23
Stockholm 23
Marseille 22
Warsaw 22
Hangzhou 21
Cape Town 20
Biên Hòa 19
Totale 30.230
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Nome #
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors 478
Targeting the Central Nervous System: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123 467
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 458
PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid 437
7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study 433
Nanoparticulate drug carriers based on hybrid poly(D,L-lactide-co-glycolide)-dendron structures 421
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 420
Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution 420
The Impact of Lipid Corona on Rifampicin Intramacrophagic Transport Using Inhaled Solid Lipid Nanoparticles Surface-Decorated with a Mannosylated Surfactant 413
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 412
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution 408
Laboratorio di Preparazione Estrattiva e Sintetica dei Farmaci 402
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors 396
Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier 385
Challenges in the design of clinically useful brain-targeted drug nanocarriers 373
Polymeric nanoparticles for the drug delivery to the central nervous system 373
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 371
Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase 370
A rational approach to the design of flavones as xanthine oxidase inhibitors 369
Aldose reductase does catalyse the reduction of glyceraldehyde through a stoichiometric oxidation of NADPH. 360
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 360
Privileged structures as leads in medicinal chemistry 356
Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy 352
Current and Future Chemotherapy for Chagas Disease 343
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 342
Development of flavonoids derivatives as leads against Leishmaniasis and Trypanosomiasis-invited lecture 338
A model of the interaction of substrates and inhibitors with xanthine oxidase 337
Anti-TB inhalation therapy: Design of mannose-based functionalised Solid Lipid Microparticles for an active targeting to alveolar macrophages 337
Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands 331
New aldose reductase inhibitors as potential agents for the prevention of long-term diabetic complications 330
STAT3 as Target for cancer drug discovery 330
Is there a clinical future for polymeric nanoparticles as brain targeting drug delivery agents? 329
ANTICANCER DRUGS 329
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 328
ANTIINFLAMMATORY ACTIVITY OF NEWLY SYNTHESIZED 2,6-BIS-(1,1-DIMETHYLETHYL)PHENOL DERIVATIVES 328
Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors 327
Conjugated poly(D,L-lactide-co-glycolide) for the preparation of in vivo detectable nanoparticles 327
Synthesis and description of chalcone-like compounds, inhibitors of aldose reductase 327
Activity of polyphenolic crude extracts as scavengers of superoxide radicals and inhibitors of xanthine oxidase 324
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 323
Soft docking and multiple receptor conformations in virtual screening. 318
Binding of 1-benzopyran-4-one derivatives to aldose reductase: A free energy perturbation study 315
Novel engineered lipid-based nanoparticles for pulmonary tuberculosis inhalation therapy 314
Colloidal systems for CNS drug delivery 306
Designed multiple ligands: basic research vs clinical outcomes 301
Magnetic and Optical Bistability in Tetrairon(III) Single Molecule Magnets Functionalized with Azobenzene Groups 300
Structure-based design of an inhibitor modeled at the substrate active site of aldose reductase 299
Applicazione delle tecniche microscopiche, spettroscopiche e calorimetriche nella caratterizzazione di nanoparticelle funzionalizzate 297
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent 296
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 291
Isolation and Pharmacological Activities of the Tecoma stans Alkaloids 290
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 287
Iron acquisition pathways as targets for antitubercular drugs 287
Glycopeptide-decorated nanoparticles as drug carriers for CNS: effects of surface coverage and carbohydrate type 287
Synthesis and activity of a new series of chalcones as aldose reductase inhibitors 286
Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives 286
A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors 283
Ghrelin receptor modulators: a patent review (2011-2014) 283
Structural bases for the inhibition of aldose reductase by phenolic compounds 281
Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches 281
Binding of beta-carbolines and related agents at serotonin (5-HT-2 and 5-HT-1A), dopamine (D-2) and benzodiazepine receptors 274
Peptide-derivatized biodegradable nanoparticles able to cross the blood brain barrier 272
Nitrophenyl derivatives as Aldose Reductase inhibitors 272
Folate: Relevance of Chemical and Microbial Production 272
Small-angle neutron scattering characterization of liposomes for anti-tuberculosis inhaled therapy. 271
Ghrelin receptor modulators and their therapeutic potential 271
In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment? 271
Cell internalization study of hybrid chitosan-heparin-PLGA nanocarriers on Caco-2 cells 269
Pharmacological approaches to the treatment of diabetic complications 263
ANTHOCYANIDINES AS INHIBITORS OF XANTHINE-OXIDASE 261
Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders 261
Synthesis and Aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones. 260
Identificazione, caratterizzazione e proprietà biologiche di derivati calconici da GLYCYRRHIZA GLABRA L. 260
Engineered polylactide-co-glycolide(PLGA) Np as drug delivery systems for the Central Nervous System 260
Discovery of new inhibitors of aldose reductase from molecular docking and database screening 259
Physico-chemical properties of anthocyanidins. Part 1. Theoretical evaluation of the stability of the neutral and anionic tautomeric forms 256
Oxidative modification of aldose reductase induced by copper ion. Factors and conditions affecting the process 255
Quantitative measurement of proton dissociation and tautomeric constants of apigeninidin 253
SURFACE ENGINEERING OF SOLID LIPID NANOASSEMBLIES FOR INHALED INTRAMACROPHAGIC ANTI-TB THERAPY 253
Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic? 251
Drugs/lamellae interface influences the inner structure of double-loaded liposomes for inhaled anti-TB therapy: An in-depth small-angle neutron scattering investigation 251
New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents 251
COMPOSTI AD ATTIVITÀ ANTIPARASSITARIA 250
Aerodynamic performance of lipid-based nanocarrier functionalized by novel mannose derivatives for Rifampicin intramacrophagic delivery 249
Activité Antilipoperoxydante d'Extraits Polyphenoliques de Ribes Nigrum L. 248
An overview on the potential antimycobacterial agents targeting serine/threonine protein kinases from Mycobacterium tuberculosis 248
Solvent effects on the tautomerism of apigeninidin 247
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 247
Nanoparticelle per il direzionamento cerebrale di farmaci 245
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 243
Surface decorated nanoparticles as drug delivery agents to the brain 241
Interaction of nanoparticles with immunocompetent cells: nanosafety considerations. 241
Theoretical and experimental study of flavones as inhibitors of xanthine oxidase 239
Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors 234
Peptide-decorated nanoparticles as carriers for drug delivery to CNS 233
Modified PLGA Nanoparticles as drug carriers for CNS delivery 232
Composition, Superoxide Radicals Scavenging and Antilipoperoxidant Activity of some Edible Fruits 230
Nanoparticles for drug delivery to the CNS 230
Synthesis of novel benzoic acid derivatives with benzothiazolyl subunit and evaluation as aldose reductase inhibitors 230
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 228
Totale 30.833
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Categoria #
all - tutte 162.515
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 162.515
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20223.031 93 396 425 199 79 155 167 206 290 200 487 334
2022/20233.139 417 341 225 281 420 479 73 246 410 54 114 79
2023/20241.868 69 119 105 191 431 178 177 246 57 51 79 165
2024/20256.613 287 86 133 447 1.315 925 450 424 663 416 696 771
2025/202613.336 696 503 1.195 1.752 2.514 981 1.355 641 1.183 970 867 679
2026/2027260 260 0 0 0 0 0 0 0 0 0 0 0
Totale 43.422