COSTANTINO, Luca
 Distribuzione geografica
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Continente #
NA - Nord America 14.456
EU - Europa 6.684
AS - Asia 1.508
AF - Africa 36
SA - Sud America 34
OC - Oceania 16
Continente sconosciuto - Info sul continente non disponibili 11
Totale 22.745
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Nazione #
US - Stati Uniti d'America 14.421
GB - Regno Unito 2.656
IT - Italia 1.127
SE - Svezia 918
DE - Germania 654
CN - Cina 617
UA - Ucraina 441
TR - Turchia 328
HK - Hong Kong 304
FI - Finlandia 229
FR - Francia 179
BG - Bulgaria 174
IN - India 81
RU - Federazione Russa 60
KR - Corea 46
BE - Belgio 38
IE - Irlanda 37
CH - Svizzera 30
NL - Olanda 29
PL - Polonia 29
BR - Brasile 26
CA - Canada 25
RO - Romania 23
SG - Singapore 23
JP - Giappone 21
IR - Iran 20
ID - Indonesia 19
ES - Italia 18
ZA - Sudafrica 16
AU - Australia 13
PT - Portogallo 12
EU - Europa 11
BD - Bangladesh 10
AT - Austria 6
EG - Egitto 6
GR - Grecia 6
MX - Messico 6
TW - Taiwan 6
VN - Vietnam 6
MY - Malesia 5
PK - Pakistan 5
BZ - Belize 4
CL - Cile 4
IQ - Iraq 4
NO - Norvegia 4
SN - Senegal 4
NG - Nigeria 3
NZ - Nuova Zelanda 3
RS - Serbia 3
TZ - Tanzania 3
AE - Emirati Arabi Uniti 2
AR - Argentina 2
CZ - Repubblica Ceca 2
DK - Danimarca 2
DZ - Algeria 2
HU - Ungheria 2
IL - Israele 2
LK - Sri Lanka 2
PH - Filippine 2
VE - Venezuela 2
AL - Albania 1
BY - Bielorussia 1
CM - Camerun 1
HR - Croazia 1
JO - Giordania 1
KH - Cambogia 1
MA - Marocco 1
MD - Moldavia 1
MO - Macao, regione amministrativa speciale della Cina 1
NP - Nepal 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
Totale 22.745
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Città #
Southend 2.220
Fairfield 2.116
Woodbridge 1.451
Chandler 1.119
Ashburn 1.116
Houston 1.004
Jacksonville 934
Seattle 934
Ann Arbor 788
Wilmington 783
Dearborn 751
Cambridge 741
Nyköping 559
Hong Kong 298
Beijing 239
Modena 213
Izmir 202
San Diego 201
Princeton 198
Sofia 169
Eugene 166
Bremen 125
Redwood City 98
Helsinki 85
Frankfurt am Main 81
New York 76
Des Moines 69
London 53
Milan 53
Fremont 48
Shanghai 41
Rome 37
Dublin 36
Verona 36
Bologna 35
Hefei 33
Nanjing 32
Norwalk 30
Boardman 26
Napoli 26
Brussels 24
Kunming 22
Parma 21
Guangzhou 19
Kraków 19
Los Angeles 19
Philadelphia 18
Falls Church 17
Saint Petersburg 17
San Mateo 17
Jinan 16
Sassuolo 16
Auburn Hills 15
Chiswick 15
Kilburn 14
Cape Town 13
Naples 13
Tokyo 12
Hounslow 11
Reggio Nell'emilia 11
Basel 10
Carmichael 10
Ferrara 10
Indiana 10
San Francisco 10
Nanchang 9
Negrar 9
Phoenix 9
Segrate 9
Seoul 9
Toronto 9
Fuzhou 8
Grafing 8
Hangzhou 8
Leawood 8
Trieste 8
Augusta 7
Avellino 7
New Delhi 7
Ottawa 7
Pisa 7
Siena 7
Washington 7
Zhengzhou 7
Chongqing 6
Deford 6
Dongguan 6
Hebei 6
Madrid 6
Mountain View 6
Mumbai 6
Porto 6
Sydney 6
Aiseau 5
Atlanta 5
Boston 5
Cagliari 5
Chicago 5
Florence 5
Montebelluna 5
Totale 17.840
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Nome #
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 311
The Impact of Lipid Corona on Rifampicin Intramacrophagic Transport Using Inhaled Solid Lipid Nanoparticles Surface-Decorated with a Mannosylated Surfactant 305
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 259
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors 255
7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study 237
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 235
Current and Future Chemotherapy for Chagas Disease 229
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 213
Targeting the Central Nervous System: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123 208
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 208
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 208
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 205
Laboratorio di Preparazione Estrattiva e Sintetica dei Farmaci 198
PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid 198
Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy 197
Synthesis and description of chalcone-like compounds, inhibitors of aldose reductase 196
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 195
Structure-based design of an inhibitor modeled at the substrate active site of aldose reductase 194
ANTIINFLAMMATORY ACTIVITY OF NEWLY SYNTHESIZED 2,6-BIS-(1,1-DIMETHYLETHYL)PHENOL DERIVATIVES 192
Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution 191
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent 190
New aldose reductase inhibitors as potential agents for the prevention of long-term diabetic complications 184
Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors 182
Folate: Relevance of Chemical and Microbial Production 180
Colloidal systems for CNS drug delivery 179
Iron acquisition pathways as targets for antitubercular drugs 177
Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives 176
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors 176
Isolation and Pharmacological Activities of the Tecoma stans Alkaloids 172
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution 172
Binding of 1-benzopyran-4-one derivatives to aldose reductase: A free energy perturbation study 169
Synthesis and activity of a new series of chalcones as aldose reductase inhibitors 167
A rational approach to the design of flavones as xanthine oxidase inhibitors 167
Glycopeptide-decorated nanoparticles as drug carriers for CNS: effects of surface coverage and carbohydrate type 166
ANTICANCER DRUGS 165
Quantitative measurement of proton dissociation and tautomeric constants of apigeninidin 165
Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier 165
Aldose reductase does catalyse the reduction of glyceraldehyde through a stoichiometric oxidation of NADPH. 164
Nanoparticulate drug carriers based on hybrid poly(D,L-lactide-co-glycolide)-dendron structures 164
Anti-TB inhalation therapy: Design of mannose-based functionalised Solid Lipid Microparticles for an active targeting to alveolar macrophages 164
Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches 163
Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase 163
Soft docking and multiple receptor conformations in virtual screening. 162
Polymeric nanoparticles for the drug delivery to the central nervous system 160
Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders 160
Structural bases for the inhibition of aldose reductase by phenolic compounds 159
Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic? 158
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 157
Synthesis and aldose reductase inhibitory activity of a new series of benzo[h]cinnolinone derivatives 156
Magnetic and Optical Bistability in Tetrairon(III) Single Molecule Magnets Functionalized with Azobenzene Groups 156
Synthesis of novel benzoic acid derivatives with benzothiazolyl subunit and evaluation as aldose reductase inhibitors 156
Molecular dynamics simulations of the structure of aldose reductase complexed with the inhibitor Tolrestat 154
Solvent effects on the tautomerism of apigeninidin 153
Privileged structures as leads in medicinal chemistry 153
Development of flavonoids derivatives as leads against Leishmaniasis and Trypanosomiasis-invited lecture 153
Physico-chemical properties of anthocyanidins. Part 1. Theoretical evaluation of the stability of the neutral and anionic tautomeric forms 152
Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors 152
Theoretical and experimental study of flavones as inhibitors of xanthine oxidase 152
Synthesis and Aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones. 150
A model of the interaction of substrates and inhibitors with xanthine oxidase 150
Heteroarylalkanoic acids with possible antiinflammatory activities, III 150
Interaction of nanoparticles with immunocompetent cells: nanosafety considerations. 150
Pharmacological approaches to the treatment of diabetic complications 148
Activity of polyphenolic crude extracts as scavengers of superoxide radicals and inhibitors of xanthine oxidase 147
Peptide-derivatized biodegradable nanoparticles able to cross the blood brain barrier 147
Oxidative modification of aldose reductase induced by copper ion. Factors and conditions affecting the process 147
Discovery of new inhibitors of aldose reductase from molecular docking and database screening 147
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 146
Challenges in the design of clinically useful brain-targeted drug nanocarriers 145
Synthesis and aldose reductase inhibitory activities of novel thienocinnolinone derivatives 145
Newly synthesized surfactants for surface mannosylation of respirable SLN assemblies to target macrophages in tuberculosis therapy 145
Novel engineered lipid-based nanoparticles for pulmonary tuberculosis inhalation therapy 145
On the prodrug-potential of novel Aldose reductase inhibitors with diphenylmethyleneaminooxycarboxylic acid structure 144
Nitrophenyl derivatives as Aldose Reductase inhibitors 143
STAT3 as Target for cancer drug discovery 142
Conjugated poly(D,L-lactide-co-glycolide) for the preparation of in vivo detectable nanoparticles 142
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 140
Drugs/lamellae interface influences the inner structure of double-loaded liposomes for inhaled anti-TB therapy: An in-depth small-angle neutron scattering investigation 139
Small-angle neutron scattering characterization of liposomes for anti-tuberculosis inhaled therapy. 138
Free energy perturbation studies on binding of the inhibitor 5,6-dihydrobenzo[h]cinnolin-3(2H)one-2-acetic acid and its methoxylated analogs to aldose reductase 137
Growth hormone secretagogue receptor antagonists 136
Thienocinnolinone alkanoic acid derivatives as aldose reductase inhibitors 135
Is there a clinical future for polymeric nanoparticles as brain targeting drug delivery agents? 134
New perspectives on the development of antiobesity drugs 134
Cell internalization study of hybrid chitosan-heparin-PLGA nanocarriers on Caco-2 cells 131
Composition, Superoxide Radicals Scavenging and Antilipoperoxidant Activity of some Edible Fruits 130
Surface decorated nanoparticles as drug delivery agents to the brain 130
In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment? 130
COMPOSTI AD ATTIVITÀ ANTIPARASSITARIA 129
Challenges in the design of multitarget drugs against multifactorial pathologies: a new life for medicinal chemistry? 128
Designed multiple ligands: basic research vs clinical outcomes 127
Dottorato regionale Spinner-Nuove molecole per il controllo e la differenziazione delle cellule staminali-NovaMolStam- Università di Bologna, Ferrara, Modena e Reggio Emilia, Parma-Anno 2012-2015- 127
New chromane-based derivatives as inhibitors of mycobacterium tuberculosis salicylate synthase (mbti): Preliminary biological evaluation and molecular modeling studies 125
New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents 125
Identificazione, caratterizzazione e proprietà biologiche di derivati calconici da GLYCYRRHIZA GLABRA L. 124
DETERMINATION OF DRUG - MACROMOLECULE BINDING PARAMETERS BY NUMERICAL-ANALYSIS 124
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 124
Novel triazole derivatives with improved receptor activity and bioavailability properties as ghrelin antagonists of Growth Hormone Secretagogue Receptors (WO201235124): a patent evaluation 122
Attivité antifongique in vitro de l’huille essentielle de chemotypes de lavandin 120
Ghrelin receptor modulators and their therapeutic potential 119
Totale 16.438
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Categoria #
all - tutte 80.955
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 80.955
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20191.488 0 0 0 0 0 0 0 0 0 308 616 564
2019/20205.699 364 287 233 442 671 848 918 588 622 186 305 235
2020/20214.437 502 255 368 335 450 317 323 491 214 708 298 176
2021/20223.031 93 396 425 199 79 155 167 206 290 200 487 334
2022/20233.139 417 341 225 281 420 479 73 246 410 54 114 79
2023/20241.618 69 119 105 191 431 178 177 246 57 45 0 0
Totale 22.963