COSTANTINO, Luca
 Distribuzione geografica
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Continente #
NA - Nord America 22.737
EU - Europa 9.125
AS - Asia 8.974
SA - Sud America 1.219
AF - Africa 223
OC - Oceania 31
Continente sconosciuto - Info sul continente non disponibili 12
Totale 42.321
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Nazione #
US - Stati Uniti d'America 22.451
GB - Regno Unito 3.110
SG - Singapore 2.634
CN - Cina 2.542
IT - Italia 1.623
SE - Svezia 1.044
VN - Vietnam 1.017
HK - Hong Kong 1.010
BR - Brasile 952
DE - Germania 816
UA - Ucraina 494
RU - Federazione Russa 446
FI - Finlandia 424
FR - Francia 402
TR - Turchia 393
KR - Corea 297
IN - India 248
BD - Bangladesh 245
BG - Bulgaria 177
CA - Canada 150
NL - Olanda 122
AR - Argentina 89
JP - Giappone 86
MX - Messico 81
ID - Indonesia 79
IQ - Iraq 77
ZA - Sudafrica 66
PL - Polonia 62
IE - Irlanda 60
ES - Italia 59
BE - Belgio 48
PK - Pakistan 48
EC - Ecuador 42
CH - Svizzera 39
AE - Emirati Arabi Uniti 36
CL - Cile 35
MA - Marocco 31
PH - Filippine 29
LT - Lituania 28
AU - Australia 27
RO - Romania 27
PY - Paraguay 25
CO - Colombia 24
EG - Egitto 24
VE - Venezuela 23
AT - Austria 21
SA - Arabia Saudita 21
IR - Iran 20
KE - Kenya 20
TW - Taiwan 20
DZ - Algeria 19
JO - Giordania 19
PT - Portogallo 18
AZ - Azerbaigian 17
MY - Malesia 17
MD - Moldavia 15
TH - Thailandia 15
UZ - Uzbekistan 15
CZ - Repubblica Ceca 14
NP - Nepal 14
PE - Perù 14
TN - Tunisia 13
BY - Bielorussia 11
EU - Europa 11
UY - Uruguay 10
DK - Danimarca 9
GR - Grecia 9
SN - Senegal 9
IL - Israele 8
JM - Giamaica 8
NO - Norvegia 8
CR - Costa Rica 7
DO - Repubblica Dominicana 7
KZ - Kazakistan 7
LB - Libano 7
LK - Sri Lanka 7
RS - Serbia 7
AO - Angola 6
BH - Bahrain 6
EE - Estonia 6
ET - Etiopia 6
GT - Guatemala 6
QA - Qatar 6
CI - Costa d'Avorio 5
KG - Kirghizistan 5
NG - Nigeria 5
NI - Nicaragua 5
AL - Albania 4
BO - Bolivia 4
BZ - Belize 4
GE - Georgia 4
HR - Croazia 4
HU - Ungheria 4
KW - Kuwait 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
OM - Oman 4
PA - Panama 4
PS - Palestinian Territory 4
SK - Slovacchia (Repubblica Slovacca) 4
Totale 42.267
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Città #
Southend 2.220
Fairfield 2.118
Ashburn 1.926
Santa Clara 1.855
Singapore 1.619
Woodbridge 1.451
Chandler 1.119
Houston 1.026
Hong Kong 994
Seattle 945
Jacksonville 941
Hefei 858
Wilmington 820
Ann Arbor 788
Dearborn 751
Cambridge 742
Chicago 627
San Jose 611
Nyköping 559
Los Angeles 453
Beijing 433
London 408
Ho Chi Minh City 319
Council Bluffs 283
Salt Lake City 264
Helsinki 261
The Dalles 256
Hanoi 247
Seoul 246
Modena 225
Izmir 207
San Diego 206
Princeton 198
New York 180
Sofia 170
Eugene 166
Milan 157
Dallas 146
Frankfurt am Main 145
Buffalo 142
Lauterbourg 136
Bremen 125
Moscow 124
Shanghai 106
Elk Grove Village 103
Redwood City 98
Tampa 91
Orem 79
São Paulo 75
Tokyo 70
Des Moines 69
Rome 67
Dublin 57
Lancaster 55
Munich 55
Sterling 53
Guangzhou 49
Bologna 48
Columbus 48
Fremont 48
Phoenix 47
Da Nang 43
Haiphong 43
Chennai 42
Atlanta 40
Verona 39
Boardman 37
Miami 37
Nanjing 37
Jakarta 34
Mexico City 34
Amsterdam 33
Denver 33
Montreal 33
Toronto 32
Parma 31
Brussels 30
Detroit 30
Norwalk 30
Rio de Janeiro 30
Philadelphia 29
Baghdad 27
Brooklyn 27
Jinan 27
Kunming 27
Mumbai 27
Napoli 26
Naples 25
San Francisco 25
Belo Horizonte 24
Dulles 24
New Delhi 23
Paris 23
Stockholm 23
Marseille 22
Miano 22
Warsaw 22
Cape Town 20
Hangzhou 20
Biên Hòa 19
Totale 29.835
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Nome #
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors 473
Targeting the Central Nervous System: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123 466
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 445
PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid 434
7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study 420
Nanoparticulate drug carriers based on hybrid poly(D,L-lactide-co-glycolide)-dendron structures 418
Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution 414
The Impact of Lipid Corona on Rifampicin Intramacrophagic Transport Using Inhaled Solid Lipid Nanoparticles Surface-Decorated with a Mannosylated Surfactant 409
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution 403
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 402
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 400
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors 393
Laboratorio di Preparazione Estrattiva e Sintetica dei Farmaci 383
Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier 380
Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase 369
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 367
A rational approach to the design of flavones as xanthine oxidase inhibitors 364
Polymeric nanoparticles for the drug delivery to the central nervous system 363
Challenges in the design of clinically useful brain-targeted drug nanocarriers 362
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 357
Privileged structures as leads in medicinal chemistry 350
Aldose reductase does catalyse the reduction of glyceraldehyde through a stoichiometric oxidation of NADPH. 346
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 341
Current and Future Chemotherapy for Chagas Disease 336
A model of the interaction of substrates and inhibitors with xanthine oxidase 334
Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy 331
Anti-TB inhalation therapy: Design of mannose-based functionalised Solid Lipid Microparticles for an active targeting to alveolar macrophages 330
Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands 328
STAT3 as Target for cancer drug discovery 327
ANTICANCER DRUGS 327
Is there a clinical future for polymeric nanoparticles as brain targeting drug delivery agents? 326
ANTIINFLAMMATORY ACTIVITY OF NEWLY SYNTHESIZED 2,6-BIS-(1,1-DIMETHYLETHYL)PHENOL DERIVATIVES 323
Conjugated poly(D,L-lactide-co-glycolide) for the preparation of in vivo detectable nanoparticles 323
Synthesis and description of chalcone-like compounds, inhibitors of aldose reductase 321
Activity of polyphenolic crude extracts as scavengers of superoxide radicals and inhibitors of xanthine oxidase 320
Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors 319
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 319
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 316
Development of flavonoids derivatives as leads against Leishmaniasis and Trypanosomiasis-invited lecture 314
Novel engineered lipid-based nanoparticles for pulmonary tuberculosis inhalation therapy 311
Binding of 1-benzopyran-4-one derivatives to aldose reductase: A free energy perturbation study 305
Soft docking and multiple receptor conformations in virtual screening. 300
New aldose reductase inhibitors as potential agents for the prevention of long-term diabetic complications 299
Colloidal systems for CNS drug delivery 298
Designed multiple ligands: basic research vs clinical outcomes 298
Magnetic and Optical Bistability in Tetrairon(III) Single Molecule Magnets Functionalized with Azobenzene Groups 298
Applicazione delle tecniche microscopiche, spettroscopiche e calorimetriche nella caratterizzazione di nanoparticelle funzionalizzate 295
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent 294
Isolation and Pharmacological Activities of the Tecoma stans Alkaloids 286
Structure-based design of an inhibitor modeled at the substrate active site of aldose reductase 285
Synthesis and activity of a new series of chalcones as aldose reductase inhibitors 284
Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives 283
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 283
Glycopeptide-decorated nanoparticles as drug carriers for CNS: effects of surface coverage and carbohydrate type 280
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 278
A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors 278
Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches 278
Structural bases for the inhibition of aldose reductase by phenolic compounds 277
Iron acquisition pathways as targets for antitubercular drugs 274
Ghrelin receptor modulators: a patent review (2011-2014) 271
Peptide-derivatized biodegradable nanoparticles able to cross the blood brain barrier 270
Folate: Relevance of Chemical and Microbial Production 270
Small-angle neutron scattering characterization of liposomes for anti-tuberculosis inhaled therapy. 268
Ghrelin receptor modulators and their therapeutic potential 268
Binding of beta-carbolines and related agents at serotonin (5-HT-2 and 5-HT-1A), dopamine (D-2) and benzodiazepine receptors 267
Cell internalization study of hybrid chitosan-heparin-PLGA nanocarriers on Caco-2 cells 267
In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment? 266
ANTHOCYANIDINES AS INHIBITORS OF XANTHINE-OXIDASE 259
Identificazione, caratterizzazione e proprietà biologiche di derivati calconici da GLYCYRRHIZA GLABRA L. 259
Engineered polylactide-co-glycolide(PLGA) Np as drug delivery systems for the Central Nervous System 258
Nitrophenyl derivatives as Aldose Reductase inhibitors 257
Synthesis and Aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones. 255
Physico-chemical properties of anthocyanidins. Part 1. Theoretical evaluation of the stability of the neutral and anionic tautomeric forms 251
Oxidative modification of aldose reductase induced by copper ion. Factors and conditions affecting the process 251
Discovery of new inhibitors of aldose reductase from molecular docking and database screening 251
Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders 249
Pharmacological approaches to the treatment of diabetic complications 247
COMPOSTI AD ATTIVITÀ ANTIPARASSITARIA 247
Activité Antilipoperoxydante d'Extraits Polyphenoliques de Ribes Nigrum L. 246
Aerodynamic performance of lipid-based nanocarrier functionalized by novel mannose derivatives for Rifampicin intramacrophagic delivery 246
Solvent effects on the tautomerism of apigeninidin 245
Quantitative measurement of proton dissociation and tautomeric constants of apigeninidin 245
Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic? 245
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 244
SURFACE ENGINEERING OF SOLID LIPID NANOASSEMBLIES FOR INHALED INTRAMACROPHAGIC ANTI-TB THERAPY 244
Drugs/lamellae interface influences the inner structure of double-loaded liposomes for inhaled anti-TB therapy: An in-depth small-angle neutron scattering investigation 244
New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents 244
Nanoparticelle per il direzionamento cerebrale di farmaci 242
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 239
Surface decorated nanoparticles as drug delivery agents to the brain 236
Interaction of nanoparticles with immunocompetent cells: nanosafety considerations. 236
Peptide-decorated nanoparticles as carriers for drug delivery to CNS 232
Modified PLGA Nanoparticles as drug carriers for CNS delivery 231
Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors 230
Nanoparticles for drug delivery to the CNS 228
Synthesis of novel benzoic acid derivatives with benzothiazolyl subunit and evaluation as aldose reductase inhibitors 228
Composition, Superoxide Radicals Scavenging and Antilipoperoxidant Activity of some Edible Fruits 226
Attivité antifongique in vitro de l’huille essentielle de chemotypes de lavandin 226
Nanoparticelle polimeriche per il direzionamento di farmaci al Sistema Nervoso Centrale 225
Theoretical and experimental study of flavones as inhibitors of xanthine oxidase 225
Totale 30.175
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Categoria #
all - tutte 156.636
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 156.636
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021176 0 0 0 0 0 0 0 0 0 0 0 176
2021/20223.031 93 396 425 199 79 155 167 206 290 200 487 334
2022/20233.139 417 341 225 281 420 479 73 246 410 54 114 79
2023/20241.868 69 119 105 191 431 178 177 246 57 51 79 165
2024/20256.613 287 86 133 447 1.315 925 450 424 663 416 696 771
2025/202612.714 696 503 1.195 1.752 2.514 981 1.355 641 1.183 970 867 57
Totale 42.540