COSTANTINO, Luca
 Distribuzione geografica
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Continente #
NA - Nord America 16.448
EU - Europa 7.130
AS - Asia 2.600
SA - Sud America 60
AF - Africa 47
OC - Oceania 23
Continente sconosciuto - Info sul continente non disponibili 12
Totale 26.320
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Nazione #
US - Stati Uniti d'America 16.404
GB - Regno Unito 2.669
IT - Italia 1.239
SE - Svezia 954
CN - Cina 865
SG - Singapore 746
DE - Germania 696
UA - Ucraina 445
HK - Hong Kong 373
TR - Turchia 328
FI - Finlandia 237
RU - Federazione Russa 226
FR - Francia 182
BG - Bulgaria 174
IN - India 92
BR - Brasile 49
KR - Corea 48
IE - Irlanda 46
BE - Belgio 45
NL - Olanda 38
ID - Indonesia 35
CA - Canada 34
CH - Svizzera 31
PL - Polonia 30
JP - Giappone 23
RO - Romania 23
ZA - Sudafrica 21
AU - Australia 20
IR - Iran 20
ES - Italia 19
LT - Lituania 17
BD - Bangladesh 12
CZ - Repubblica Ceca 12
PT - Portogallo 12
EU - Europa 11
PK - Pakistan 10
TW - Taiwan 8
EG - Egitto 7
VN - Vietnam 7
AT - Austria 6
GR - Grecia 6
IQ - Iraq 6
MX - Messico 6
MA - Marocco 5
MY - Malesia 5
NO - Norvegia 5
AE - Emirati Arabi Uniti 4
BZ - Belize 4
CL - Cile 4
MD - Moldavia 4
SN - Senegal 4
BY - Bielorussia 3
LK - Sri Lanka 3
NG - Nigeria 3
NZ - Nuova Zelanda 3
PH - Filippine 3
RS - Serbia 3
TZ - Tanzania 3
AR - Argentina 2
DK - Danimarca 2
DZ - Algeria 2
EC - Ecuador 2
HU - Ungheria 2
IL - Israele 2
KZ - Kazakistan 2
TH - Thailandia 2
VE - Venezuela 2
AL - Albania 1
AM - Armenia 1
CM - Camerun 1
EE - Estonia 1
HR - Croazia 1
JO - Giordania 1
KH - Cambogia 1
MO - Macao, regione amministrativa speciale della Cina 1
NP - Nepal 1
PY - Paraguay 1
SK - Slovacchia (Repubblica Slovacca) 1
TN - Tunisia 1
UZ - Uzbekistan 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 26.320
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Città #
Southend 2.220
Fairfield 2.116
Santa Clara 1.781
Woodbridge 1.451
Ashburn 1.166
Chandler 1.119
Houston 1.004
Jacksonville 934
Seattle 934
Ann Arbor 788
Wilmington 783
Dearborn 751
Cambridge 741
Singapore 576
Nyköping 559
Hong Kong 367
Beijing 248
Modena 222
Izmir 202
San Diego 201
Princeton 198
Sofia 169
Eugene 166
Bremen 125
Frankfurt am Main 106
Redwood City 98
Helsinki 90
Moscow 82
New York 76
Des Moines 69
Milan 68
Shanghai 65
London 56
Rome 49
Fremont 48
Bologna 45
Dublin 45
Chicago 41
Hefei 36
Verona 36
Boardman 33
Nanjing 32
Norwalk 30
Brussels 29
Guangzhou 28
Parma 27
Napoli 26
Kunming 22
Jinan 20
Los Angeles 20
Kraków 19
Jakarta 18
Philadelphia 18
Falls Church 17
Saint Petersburg 17
San Mateo 17
Sassuolo 16
Auburn Hills 15
Chiswick 15
Kilburn 14
Ottawa 14
Cape Town 13
Munich 13
Naples 13
Tokyo 12
Brno 11
Fuzhou 11
Hounslow 11
Reggio Nell'emilia 11
Toronto 11
Basel 10
Carmichael 10
Ferrara 10
Indiana 10
San Francisco 10
Wuhan 10
Nanchang 9
Negrar 9
Phoenix 9
Segrate 9
Seoul 9
Dallas 8
Grafing 8
Hangzhou 8
Kyiv 8
Leawood 8
Mumbai 8
Siena 8
Trieste 8
Zhengzhou 8
Augusta 7
Avellino 7
New Delhi 7
Pisa 7
Sydney 7
Washington 7
Chongqing 6
Deford 6
Dongguan 6
Hebei 6
Totale 20.627
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Nome #
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 341
The Impact of Lipid Corona on Rifampicin Intramacrophagic Transport Using Inhaled Solid Lipid Nanoparticles Surface-Decorated with a Mannosylated Surfactant 334
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 291
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors 281
7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study 264
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 259
Laboratorio di Preparazione Estrattiva e Sintetica dei Farmaci 259
Current and Future Chemotherapy for Chagas Disease 253
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 245
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 234
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 231
Targeting the Central Nervous System: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123 230
Synthesis and description of chalcone-like compounds, inhibitors of aldose reductase 228
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 225
PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid 224
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 222
Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy 219
Nanoparticulate drug carriers based on hybrid poly(D,L-lactide-co-glycolide)-dendron structures 218
ANTIINFLAMMATORY ACTIVITY OF NEWLY SYNTHESIZED 2,6-BIS-(1,1-DIMETHYLETHYL)PHENOL DERIVATIVES 215
Structure-based design of an inhibitor modeled at the substrate active site of aldose reductase 212
Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution 212
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent 212
Colloidal systems for CNS drug delivery 204
Folate: Relevance of Chemical and Microbial Production 202
Binding of 1-benzopyran-4-one derivatives to aldose reductase: A free energy perturbation study 202
Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors 200
New aldose reductase inhibitors as potential agents for the prevention of long-term diabetic complications 199
Iron acquisition pathways as targets for antitubercular drugs 199
Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier 197
Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives 195
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors 195
ANTICANCER DRUGS 195
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution 194
A rational approach to the design of flavones as xanthine oxidase inhibitors 192
Anti-TB inhalation therapy: Design of mannose-based functionalised Solid Lipid Microparticles for an active targeting to alveolar macrophages 191
Aldose reductase does catalyse the reduction of glyceraldehyde through a stoichiometric oxidation of NADPH. 189
Glycopeptide-decorated nanoparticles as drug carriers for CNS: effects of surface coverage and carbohydrate type 189
Isolation and Pharmacological Activities of the Tecoma stans Alkaloids 188
Development of flavonoids derivatives as leads against Leishmaniasis and Trypanosomiasis-invited lecture 188
Synthesis and activity of a new series of chalcones as aldose reductase inhibitors 187
Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches 182
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 182
Polymeric nanoparticles for the drug delivery to the central nervous system 182
Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase 182
Quantitative measurement of proton dissociation and tautomeric constants of apigeninidin 180
Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic? 179
Structural bases for the inhibition of aldose reductase by phenolic compounds 178
Soft docking and multiple receptor conformations in virtual screening. 177
Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders 177
Novel engineered lipid-based nanoparticles for pulmonary tuberculosis inhalation therapy 176
A model of the interaction of substrates and inhibitors with xanthine oxidase 173
Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors 173
Magnetic and Optical Bistability in Tetrairon(III) Single Molecule Magnets Functionalized with Azobenzene Groups 173
Synthesis of novel benzoic acid derivatives with benzothiazolyl subunit and evaluation as aldose reductase inhibitors 173
Activity of polyphenolic crude extracts as scavengers of superoxide radicals and inhibitors of xanthine oxidase 172
Small-angle neutron scattering characterization of liposomes for anti-tuberculosis inhaled therapy. 171
Molecular dynamics simulations of the structure of aldose reductase complexed with the inhibitor Tolrestat 171
Synthesis and aldose reductase inhibitory activity of a new series of benzo[h]cinnolinone derivatives 171
Theoretical and experimental study of flavones as inhibitors of xanthine oxidase 171
Discovery of new inhibitors of aldose reductase from molecular docking and database screening 171
Solvent effects on the tautomerism of apigeninidin 170
Privileged structures as leads in medicinal chemistry 170
Peptide-derivatized biodegradable nanoparticles able to cross the blood brain barrier 169
Interaction of nanoparticles with immunocompetent cells: nanosafety considerations. 169
Heteroarylalkanoic acids with possible antiinflammatory activities, III 168
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 168
Conjugated poly(D,L-lactide-co-glycolide) for the preparation of in vivo detectable nanoparticles 168
Physico-chemical properties of anthocyanidins. Part 1. Theoretical evaluation of the stability of the neutral and anionic tautomeric forms 167
Pharmacological approaches to the treatment of diabetic complications 167
Synthesis and Aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones. 166
STAT3 as Target for cancer drug discovery 166
Synthesis and aldose reductase inhibitory activities of novel thienocinnolinone derivatives 166
Nitrophenyl derivatives as Aldose Reductase inhibitors 165
COMPOSTI AD ATTIVITÀ ANTIPARASSITARIA 165
Oxidative modification of aldose reductase induced by copper ion. Factors and conditions affecting the process 164
Challenges in the design of clinically useful brain-targeted drug nanocarriers 163
Drugs/lamellae interface influences the inner structure of double-loaded liposomes for inhaled anti-TB therapy: An in-depth small-angle neutron scattering investigation 163
In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment? 163
Newly synthesized surfactants for surface mannosylation of respirable SLN assemblies to target macrophages in tuberculosis therapy 161
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 161
On the prodrug-potential of novel Aldose reductase inhibitors with diphenylmethyleneaminooxycarboxylic acid structure 160
Is there a clinical future for polymeric nanoparticles as brain targeting drug delivery agents? 154
Cell internalization study of hybrid chitosan-heparin-PLGA nanocarriers on Caco-2 cells 154
Free energy perturbation studies on binding of the inhibitor 5,6-dihydrobenzo[h]cinnolin-3(2H)one-2-acetic acid and its methoxylated analogs to aldose reductase 154
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 154
Thienocinnolinone alkanoic acid derivatives as aldose reductase inhibitors 152
Composition, Superoxide Radicals Scavenging and Antilipoperoxidant Activity of some Edible Fruits 151
Surface decorated nanoparticles as drug delivery agents to the brain 149
New perspectives on the development of antiobesity drugs 149
Identificazione, caratterizzazione e proprietà biologiche di derivati calconici da GLYCYRRHIZA GLABRA L. 148
Growth hormone secretagogue receptor antagonists 148
A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors 145
Applicazione delle tecniche microscopiche, spettroscopiche e calorimetriche nella caratterizzazione di nanoparticelle funzionalizzate 144
Challenges in the design of multitarget drugs against multifactorial pathologies: a new life for medicinal chemistry? 144
Attivité antifongique in vitro de l’huille essentielle de chemotypes de lavandin 144
DETERMINATION OF DRUG - MACROMOLECULE BINDING PARAMETERS BY NUMERICAL-ANALYSIS 144
New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents 144
New chromane-based derivatives as inhibitors of mycobacterium tuberculosis salicylate synthase (mbti): Preliminary biological evaluation and molecular modeling studies 143
Dottorato regionale Spinner-Nuove molecole per il controllo e la differenziazione delle cellule staminali-NovaMolStam- Università di Bologna, Ferrara, Modena e Reggio Emilia, Parma-Anno 2012-2015- 143
SURFACE ENGINEERING OF SOLID LIPID NANOASSEMBLIES FOR INHALED INTRAMACROPHAGIC ANTI-TB THERAPY 142
Totale 18.714
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Categoria #
all - tutte 109.220
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 109.220
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.854 0 0 0 0 0 0 918 588 622 186 305 235
2020/20214.437 502 255 368 335 450 317 323 491 214 708 298 176
2021/20223.031 93 396 425 199 79 155 167 206 290 200 487 334
2022/20233.139 417 341 225 281 420 479 73 246 410 54 114 79
2023/20241.868 69 119 105 191 431 178 177 246 57 51 79 165
2024/20253.325 287 86 133 447 1.315 925 132 0 0 0 0 0
Totale 26.538