Abstract: Nowadays, the delivery of drugs by means of intravenously administered nanosized drug carriers - polymer-drug conjugates, liposomes and micelles, is technically possible. These delivery systems are mainly designed for tumour therapy, and accumulate passively into tumours by means of the well known EPR effect. Targeted nanocarriers, that additionally contain ligands for receptors expressed on cell surfaces, are also widely studied but products of this kind are not marketed, and only a few are in clinical trial. Polymeric nanoparticles (Np) able to deliver drugs to the CNS were pioneered in 1995; a number of papers have been published dealing with brain-targeted drug delivery using polymeric Np able to cross the BBB, mainly for the treatment of brain tumours. At present, however, the translation potential of these Np seems to have been exceeded by targeted liposomes, a platform based on a well-known technology. This drug delivery system entered clinical trials soon after its discovery, while the challenges in formulation, characterization and manufacturing of brain-targeted polymeric Np and the cost/benefit ratio could be the factors that have prevented their development. A key issue is that it is virtually impossible to define the in vivo fate of polymers and especially in the brain, which is a regulatory requirement, and perhaps this is why no progress has been made. The most advanced Np for brain tumours treatment will be compared here with the published data available for those in clinical trial for tumours outside the CNS, to highlight the knowledge gaps that still penalise these delivery systems. At present, new approaches for brain tumour treatment are emerging, such as lipid Np or the use of monoclonal antibody (mAb)-drug conjugates, which avoid polymers. The possibility of success or failure in the approval of the polymeric Np currently in clinical trial will certainly affect the fate of brain-targeted Np. At present, the chances of their approval appear to be very low.

Challenges in the design of clinically useful brain-targeted drug nanocarriers / Costantino, Luca; Boraschi, D; Eaton, M.. - In: CURRENT MEDICINAL CHEMISTRY. - ISSN 0929-8673. - STAMPA. - 21(2014), pp. 4227-4246. [10.2174/0929867321666140716101921]

Challenges in the design of clinically useful brain-targeted drug nanocarriers

COSTANTINO, Luca;
2014

Abstract

Abstract: Nowadays, the delivery of drugs by means of intravenously administered nanosized drug carriers - polymer-drug conjugates, liposomes and micelles, is technically possible. These delivery systems are mainly designed for tumour therapy, and accumulate passively into tumours by means of the well known EPR effect. Targeted nanocarriers, that additionally contain ligands for receptors expressed on cell surfaces, are also widely studied but products of this kind are not marketed, and only a few are in clinical trial. Polymeric nanoparticles (Np) able to deliver drugs to the CNS were pioneered in 1995; a number of papers have been published dealing with brain-targeted drug delivery using polymeric Np able to cross the BBB, mainly for the treatment of brain tumours. At present, however, the translation potential of these Np seems to have been exceeded by targeted liposomes, a platform based on a well-known technology. This drug delivery system entered clinical trials soon after its discovery, while the challenges in formulation, characterization and manufacturing of brain-targeted polymeric Np and the cost/benefit ratio could be the factors that have prevented their development. A key issue is that it is virtually impossible to define the in vivo fate of polymers and especially in the brain, which is a regulatory requirement, and perhaps this is why no progress has been made. The most advanced Np for brain tumours treatment will be compared here with the published data available for those in clinical trial for tumours outside the CNS, to highlight the knowledge gaps that still penalise these delivery systems. At present, new approaches for brain tumour treatment are emerging, such as lipid Np or the use of monoclonal antibody (mAb)-drug conjugates, which avoid polymers. The possibility of success or failure in the approval of the polymeric Np currently in clinical trial will certainly affect the fate of brain-targeted Np. At present, the chances of their approval appear to be very low.
21
4227
4246
Challenges in the design of clinically useful brain-targeted drug nanocarriers / Costantino, Luca; Boraschi, D; Eaton, M.. - In: CURRENT MEDICINAL CHEMISTRY. - ISSN 0929-8673. - STAMPA. - 21(2014), pp. 4227-4246. [10.2174/0929867321666140716101921]
Costantino, Luca; Boraschi, D; Eaton, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1054916
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