Fragment-based drug design has been applied to Thymidylate synthase.The strategy applied is Mass Spectrometry related. identification of small molecule library that can bind to the protein represents the starting point for further drug design of a novel class of TS inhibitors with high potential as anticancer agents.
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track / Costi, Maria Paola; Ponterini, Glauco; Ferrari, Stefania; Costantino, Luca; Franchini, Silvia; Venturelli, Alberto; Genovese, Filippo. - ELETTRONICO. - (2013), pp. 1-1. (Intervento presentato al convegno SELECTBIO Discovery Congress Chemistry tenutosi a Munich, Germany nel 19th-20th March 2013).
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track.
COSTI, Maria Paola;PONTERINI, Glauco;FERRARI, Stefania;COSTANTINO, Luca;FRANCHINI, Silvia;VENTURELLI, Alberto;GENOVESE, Filippo
2013
Abstract
Fragment-based drug design has been applied to Thymidylate synthase.The strategy applied is Mass Spectrometry related. identification of small molecule library that can bind to the protein represents the starting point for further drug design of a novel class of TS inhibitors with high potential as anticancer agents.
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