Polymeric nanoparticles (Np) represent one of the most innovative non-invasive approaches for the drug delivery to the central nervous system (CNS). It is known that the ability of the Np to cross the Blood Brain Barrier (BBB), thus allowing the drugs to exert their pharmacological activity in the central nervous district, is linked to their surface characteristics. Recently it was shown that the biocompatible polyester poly(D,L-lactide-co-glycolide) (PLGA) derivatized with the peptide H2N-Gly-L-Phe-D-Thr-Gly-L-Phe-L-Leu-L-Ser(O--D-Glucose)-CONH2 [g7] was an useful starting material for the preparation of Np (g7-Np); moreover, fluorescent studies showed that these Np were able to cross the BBB. In this research, g-7 Np were loaded with Loperamide in order to assess their ability as drug carriers for CNS, and with Rhodamine-123, in order to qualitatively determine their biodistribution in different brain macro-areas. A pharmacological evidence is given that g7-Np are able to cross the BBB, ensuring, for the first time, a sustained release of the embedded drug, and that these Np are able to reach all the brain areas here examined. The ability to enter the CNS appears to be linked to the sequence of the peptidic moiety present on their surface.

Nanoparticelle per il direzionamento cerebrale di farmaci / Tosi, Giovanni; Costantino, Luca; Gandolfi, Francesca; Ruozi, Barbara; Rivasi, Francesco; Vandelli, Maria Angela; Forni, Flavio. - In: NCF. NOTIZIARIO CHIMICO E FARMACEUTICO. - ISSN 0393-3733. - STAMPA. - 1:(2006), pp. 98-100.

Nanoparticelle per il direzionamento cerebrale di farmaci

TOSI, Giovanni;COSTANTINO, Luca;GANDOLFI, Francesca;RUOZI, Barbara;RIVASI, Francesco;VANDELLI, Maria Angela;FORNI, Flavio
2006

Abstract

Polymeric nanoparticles (Np) represent one of the most innovative non-invasive approaches for the drug delivery to the central nervous system (CNS). It is known that the ability of the Np to cross the Blood Brain Barrier (BBB), thus allowing the drugs to exert their pharmacological activity in the central nervous district, is linked to their surface characteristics. Recently it was shown that the biocompatible polyester poly(D,L-lactide-co-glycolide) (PLGA) derivatized with the peptide H2N-Gly-L-Phe-D-Thr-Gly-L-Phe-L-Leu-L-Ser(O--D-Glucose)-CONH2 [g7] was an useful starting material for the preparation of Np (g7-Np); moreover, fluorescent studies showed that these Np were able to cross the BBB. In this research, g-7 Np were loaded with Loperamide in order to assess their ability as drug carriers for CNS, and with Rhodamine-123, in order to qualitatively determine their biodistribution in different brain macro-areas. A pharmacological evidence is given that g7-Np are able to cross the BBB, ensuring, for the first time, a sustained release of the embedded drug, and that these Np are able to reach all the brain areas here examined. The ability to enter the CNS appears to be linked to the sequence of the peptidic moiety present on their surface.
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Nanoparticelle per il direzionamento cerebrale di farmaci / Tosi, Giovanni; Costantino, Luca; Gandolfi, Francesca; Ruozi, Barbara; Rivasi, Francesco; Vandelli, Maria Angela; Forni, Flavio. - In: NCF. NOTIZIARIO CHIMICO E FARMACEUTICO. - ISSN 0393-3733. - STAMPA. - 1:(2006), pp. 98-100.
Tosi, Giovanni; Costantino, Luca; Gandolfi, Francesca; Ruozi, Barbara; Rivasi, Francesco; Vandelli, Maria Angela; Forni, Flavio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/585865
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