D'ARCA, Domenico
 Distribuzione geografica
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Continente #
NA - Nord America 5.953
EU - Europa 3.240
AS - Asia 1.071
SA - Sud America 54
OC - Oceania 7
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 1
Totale 10.331
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Nazione #
US - Stati Uniti d'America 5.929
IT - Italia 991
GB - Regno Unito 746
SE - Svezia 414
SG - Singapore 375
CN - Cina 350
DE - Germania 329
FR - Francia 173
HK - Hong Kong 104
UA - Ucraina 95
FI - Finlandia 90
RU - Federazione Russa 73
PL - Polonia 71
ID - Indonesia 65
TR - Turchia 49
BG - Bulgaria 45
IE - Irlanda 44
BE - Belgio 39
BR - Brasile 39
IN - India 35
LT - Lituania 32
ES - Italia 31
CA - Canada 22
JP - Giappone 20
NL - Olanda 18
CH - Svizzera 17
VN - Vietnam 17
TW - Taiwan 12
CL - Cile 9
KR - Corea 9
CZ - Repubblica Ceca 7
MY - Malesia 7
PK - Pakistan 7
RO - Romania 7
DK - Danimarca 6
BD - Bangladesh 5
AU - Australia 4
CO - Colombia 3
GR - Grecia 3
NO - Norvegia 3
NZ - Nuova Zelanda 3
AR - Argentina 2
AT - Austria 2
EG - Egitto 2
IR - Iran 2
MA - Marocco 2
MO - Macao, regione amministrativa speciale della Cina 2
RS - Serbia 2
SA - Arabia Saudita 2
TH - Thailandia 2
BH - Bahrain 1
BN - Brunei Darussalam 1
BY - Bielorussia 1
EU - Europa 1
GE - Georgia 1
GT - Guatemala 1
IL - Israele 1
IQ - Iraq 1
LB - Libano 1
LK - Sri Lanka 1
MX - Messico 1
PH - Filippine 1
PT - Portogallo 1
UY - Uruguay 1
ZA - Sudafrica 1
Totale 10.331
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Città #
Fairfield 783
Santa Clara 782
Southend 574
Woodbridge 437
Chandler 435
Ashburn 425
Houston 339
Ann Arbor 336
Seattle 293
Cambridge 277
Singapore 263
Nyköping 254
Wilmington 254
Modena 245
Jacksonville 190
Dearborn 187
Frankfurt am Main 138
New York 114
Hong Kong 94
San Diego 75
Beijing 70
Kraków 69
Jakarta 64
Bologna 62
Helsinki 57
Princeton 51
Fremont 50
Sofia 45
Eugene 44
Dublin 42
Boardman 33
Izmir 33
London 32
Moscow 32
Shanghai 31
Brussels 29
Munich 24
Milan 23
Parma 23
Redwood City 22
Bremen 21
Padova 17
Phoenix 15
Reggio Emilia 15
Verona 15
Dong Ket 14
Falls Church 14
Piacenza 14
Des Moines 13
Formigine 12
Guangzhou 12
Norwalk 12
Hefei 11
Osnabrück 11
Zurich 11
Barcelona 10
Jinan 10
Nanjing 10
Paris 10
Rome 10
Washington 10
Kilburn 9
Ottawa 9
San Mateo 8
Toronto 8
Argenta 7
Auburn Hills 7
Leuven 7
Madrid 7
Reggio Nell'emilia 7
Turin 7
Amsterdam 6
Brno 6
Dallas 6
Lappeenranta 6
Perugia 6
Rossdorf 6
Santiago 6
Sassuolo 6
Augusta 5
Brescello 5
Chicago 5
Ispra 5
Los Angeles 5
Rimini 5
San Giovanni Suergiu 5
San Giuliano Milanese 5
Taichung 5
Valby 5
Assago 4
Boston 4
Carpi 4
Catania 4
Chennai 4
Courbevoie 4
Draveil 4
Ferrara 4
Finale Emilia 4
Imola 4
Islamabad 4
Totale 7.816
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Nome #
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides 280
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 277
Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth 274
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 273
Repurposing of drugs targeting yap-tead functions 273
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery 271
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance 271
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 247
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth 247
Spermidine/spermine N1-acetyltransferase transient over-expression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin 244
pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells 241
Involvement of epigenetic modification of TERT promoter in response to all-trans retinoic acid in ovarian cancer cell lines 239
Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies 235
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases 234
Clusterin decreases oxidative stress in lung fibroblasts exposed to cigarette smoke 225
Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer 219
PTEROATE-PEPTIDE BIOCONJUGATE TARGETING THE FOLATE RECEPTOR IN HUMAN OVARIAN CANCER CELL LINES: TRANSPORT AND MECHANISM OF ACTION. 208
Anticancer activity of green tea polyphenols in prostate gland 204
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 204
Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells 200
The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines 200
Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin 197
Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor 196
Mitostatin, a novel mitochondrial protein, that acts as a tumor suppressor in prostate cancer cells 195
ANTICANCER DRUGS 194
The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. 193
Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum 192
Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells 186
The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression 185
MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer 183
pH sensitive PEGylated Liposomes delivering active hydrophilic peptide with anticancer activity: in vitro study on cDDP-resistant ovarian cell line 183
Clusterin (SGP-2, ApoJ) expression is downregulated in low- and high-grade human prostate cancer 182
Mitostatin Is Down-Regulated in Human Prostate Cancer and Suppresses the Invasive Phenotype of Prostate Cancer Cells 178
Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth 174
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 171
MITOSTATIN, A NOVEL MITOCHONDRIAL PROTEIN, THAT ACTS AS A TUMOR SUPPRESSOR IN PROSTATE CANCER CELLS 167
The key role of Mitostatin in the maintenance of genome stability 156
Nuclear traslocation of a truncated clusterin isoform is associated to induction of anoikis in SV40-immortalized human prostate epithelial cells. 153
Prevention of bladder cancer in the FHIT knock-out mouse model with rofecoxib, a COX-2 inhibitor 136
Clusterin is down-regulated during the progression of prostate cancer in the tramp mouse model but up-regulated during chemioprevention by green tea catechins administration 132
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy 130
Clusterin gene expression is down-regulated in transformed epithelial cells but up-regulated in fibroblasts from prostate cancer 126
LC-MS serum proteomics reveals a panel of proteins prognostic of positive responsiveness to bevacizumab therapy in late-stages ovarian cancer patients 111
Structural bases for the synergistic inhibition of human thymidylate synthase and ovarian cancer cell growth by drug combinations 109
Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma 108
Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library 104
Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma 98
A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties 97
Successful prediction of prostate cancer recurrence by gene profiling in combination with clinical data: a 5-year follow-up study. 97
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 96
Applying optical tweezers technology to reveal Thymidylate Synthase interactions with its consensus mRNA 86
design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer 85
Telomere Dysfunction Is Associated with Altered {DNA} Organization in Trichoplein/Tchp/Mitostatin ({TpMs}) Depleted Cells 79
Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase 77
Targeting the dimer-monomer equilibrium of thymidylate synthase, to accelerate protein degradation and cancer cell growth inhibition 75
Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme 75
Precision medicine through proteomics studies in drug resistant colorectal cancer 72
Development of a sensitive biochemical tool to assess the expression levels of recombinant ectopic proteins in in vitro engineered cellular systems 71
Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles 70
Integrating MS proteomics in the Medicinal Chemistry pipeline as powerful tool to overcome drug resistance issues in colorectal cancer 61
Exploiting the Optical Tweezer technology to reveal thymidylate synthase interactions with its consensus mRNA 60
Exploring thymidylate synthase mRNA binding site 1 and human TS protein interaction with optical tweezers and bicistronic expression assay 49
Structural insight into YAP-TEAD4 protein-protein interactions as target for cancer treatment 47
Targeting the Interplay of Independent Cellular Pathways and Immunity: A Challenge in Cancer Immunotherapy 40
Optical tweezers to investigate at the single-molecule level the interaction of thymidylate synthase with its consensus mRNA 29
MS Proteomics And Biochemical Characterization Of Thymidylate Synthase Dimer Destabilizer E7 To Halt Colorectal Carcinoma 22
Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation 22
Totale 10.515
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Categoria #
all - tutte 41.898
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 41.898
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.147 0 0 0 0 0 238 292 174 196 63 91 93
2020/20211.794 128 76 131 109 185 128 125 208 88 341 160 115
2021/20221.185 51 111 71 60 52 106 66 65 129 92 249 133
2022/20231.383 162 172 104 133 150 154 72 135 147 27 67 60
2023/20241.333 56 92 103 75 372 134 65 75 28 40 152 141
2024/20251.660 116 51 109 233 661 490 0 0 0 0 0 0
Totale 10.515