D'ARCA, Domenico
 Distribuzione geografica
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Continente #
NA - Nord America 5.104
EU - Europa 2.989
AS - Asia 644
SA - Sud America 12
OC - Oceania 6
Continente sconosciuto - Info sul continente non disponibili 1
Totale 8.756
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Nazione #
US - Stati Uniti d'America 5.086
IT - Italia 909
GB - Regno Unito 739
SE - Svezia 385
DE - Germania 307
CN - Cina 264
FR - Francia 170
SG - Singapore 100
HK - Hong Kong 96
UA - Ucraina 95
FI - Finlandia 85
PL - Polonia 70
TR - Turchia 49
BG - Bulgaria 45
IE - Irlanda 42
BE - Belgio 36
IN - India 34
ID - Indonesia 32
LT - Lituania 27
JP - Giappone 18
CA - Canada 17
ES - Italia 15
VN - Vietnam 15
RU - Federazione Russa 13
CH - Svizzera 10
NL - Olanda 10
TW - Taiwan 10
KR - Corea 9
CL - Cile 7
CZ - Repubblica Ceca 7
MY - Malesia 7
RO - Romania 7
DK - Danimarca 6
BR - Brasile 4
AU - Australia 3
BD - Bangladesh 3
GR - Grecia 3
NZ - Nuova Zelanda 3
AT - Austria 2
IR - Iran 2
MO - Macao, regione amministrativa speciale della Cina 2
NO - Norvegia 2
RS - Serbia 2
TH - Thailandia 2
BY - Bielorussia 1
CO - Colombia 1
EU - Europa 1
IL - Israele 1
MX - Messico 1
PT - Portogallo 1
Totale 8.756
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Città #
Fairfield 783
Southend 574
Woodbridge 437
Chandler 435
Ashburn 420
Houston 339
Ann Arbor 336
Seattle 293
Cambridge 277
Nyköping 254
Wilmington 254
Modena 241
Jacksonville 190
Dearborn 187
Frankfurt am Main 137
New York 114
Hong Kong 91
San Diego 75
Beijing 70
Kraków 69
Singapore 57
Helsinki 53
Princeton 51
Fremont 50
Sofia 45
Eugene 44
Dublin 40
Bologna 39
Izmir 33
Boardman 32
Jakarta 31
London 31
Shanghai 30
Brussels 27
Parma 23
Redwood City 22
Bremen 21
Padova 17
Milan 15
Phoenix 15
Dong Ket 14
Falls Church 14
Piacenza 14
Des Moines 13
Formigine 12
Norwalk 12
Verona 12
Hefei 11
Reggio Emilia 11
Nanjing 10
Washington 10
Guangzhou 9
Kilburn 9
Munich 9
Ottawa 9
Osnabrück 8
Paris 8
Rome 8
San Mateo 8
Argenta 7
Auburn Hills 7
Leuven 7
Reggio Nell'emilia 7
Turin 7
Barcelona 6
Brno 6
Perugia 6
Rossdorf 6
Sassuolo 6
Zurich 6
Augusta 5
Brescello 5
Chicago 5
Ispra 5
Lappeenranta 5
Los Angeles 5
San Giovanni Suergiu 5
San Giuliano Milanese 5
Taichung 5
Toronto 5
Valby 5
Amsterdam 4
Assago 4
Boston 4
Carpi 4
Catania 4
Chennai 4
Courbevoie 4
Draveil 4
Ferrara 4
Finale Emilia 4
Imola 4
Jinan 4
Kunming 4
Marseille 4
Misterbianco 4
Montecarlo 4
Mountain View 4
Naples 4
Napoli 4
Totale 6.655
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Nome #
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 259
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance 254
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery 250
Repurposing of drugs targeting yap-tead functions 247
Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth 244
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides 238
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 228
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth 227
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 224
Spermidine/spermine N1-acetyltransferase transient over-expression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin 222
pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells 221
Involvement of epigenetic modification of TERT promoter in response to all-trans retinoic acid in ovarian cancer cell lines 217
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases 215
Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies 214
Clusterin decreases oxidative stress in lung fibroblasts exposed to cigarette smoke 205
Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer 197
PTEROATE-PEPTIDE BIOCONJUGATE TARGETING THE FOLATE RECEPTOR IN HUMAN OVARIAN CANCER CELL LINES: TRANSPORT AND MECHANISM OF ACTION. 186
The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines 184
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 184
Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor 181
Anticancer activity of green tea polyphenols in prostate gland 180
Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin 179
The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. 178
Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells 177
Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum 176
ANTICANCER DRUGS 170
MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer 168
The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression 168
Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells 168
pH sensitive PEGylated Liposomes delivering active hydrophilic peptide with anticancer activity: in vitro study on cDDP-resistant ovarian cell line 165
Mitostatin Is Down-Regulated in Human Prostate Cancer and Suppresses the Invasive Phenotype of Prostate Cancer Cells 161
Clusterin (SGP-2, ApoJ) expression is downregulated in low- and high-grade human prostate cancer 160
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 152
MITOSTATIN, A NOVEL MITOCHONDRIAL PROTEIN, THAT ACTS AS A TUMOR SUPPRESSOR IN PROSTATE CANCER CELLS 151
Mitostatin, a novel mitochondrial protein, that acts as a tumor suppressor in prostate cancer cells 147
Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth 143
Nuclear traslocation of a truncated clusterin isoform is associated to induction of anoikis in SV40-immortalized human prostate epithelial cells. 136
The key role of Mitostatin in the maintenance of genome stability 136
Prevention of bladder cancer in the FHIT knock-out mouse model with rofecoxib, a COX-2 inhibitor 120
Clusterin is down-regulated during the progression of prostate cancer in the tramp mouse model but up-regulated during chemioprevention by green tea catechins administration 115
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy 110
Clusterin gene expression is down-regulated in transformed epithelial cells but up-regulated in fibroblasts from prostate cancer 108
Structural bases for the synergistic inhibition of human thymidylate synthase and ovarian cancer cell growth by drug combinations 90
Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library 85
LC-MS serum proteomics reveals a panel of proteins prognostic of positive responsiveness to bevacizumab therapy in late-stages ovarian cancer patients 83
Successful prediction of prostate cancer recurrence by gene profiling in combination with clinical data: a 5-year follow-up study. 80
Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma 78
Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma 71
A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties 70
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 65
design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer 61
Applying optical tweezers technology to reveal Thymidylate Synthase interactions with its consensus mRNA 60
Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme 55
Telomere Dysfunction Is Associated with Altered {DNA} Organization in Trichoplein/Tchp/Mitostatin ({TpMs}) Depleted Cells 54
Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase 50
Targeting the dimer-monomer equilibrium of thymidylate synthase, to accelerate protein degradation and cancer cell growth inhibition 50
Development of a sensitive biochemical tool to assess the expression levels of recombinant ectopic proteins in in vitro engineered cellular systems 41
Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles 38
Exploiting the Optical Tweezer technology to reveal thymidylate synthase interactions with its consensus mRNA 33
Precision medicine through proteomics studies in drug resistant colorectal cancer 30
Structural insight into YAP-TEAD4 protein-protein interactions as target for cancer treatment 30
Integrating MS proteomics in the Medicinal Chemistry pipeline as powerful tool to overcome drug resistance issues in colorectal cancer 30
Targeting the Interplay of Independent Cellular Pathways and Immunity: A Challenge in Cancer Immunotherapy 17
Totale 8.936
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Categoria #
all - tutte 34.745
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 34.745
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.687 101 83 48 137 171 238 292 174 196 63 91 93
2020/20211.794 128 76 131 109 185 128 125 208 88 341 160 115
2021/20221.185 51 111 71 60 52 106 66 65 129 92 249 133
2022/20231.383 162 172 104 133 150 154 72 135 147 27 67 60
2023/20241.333 56 92 103 75 372 134 65 75 28 40 152 141
2024/202581 81 0 0 0 0 0 0 0 0 0 0 0
Totale 8.936