| Nome |
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Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting, file e31e124f-6460-987f-e053-3705fe0a095a
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402
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Repurposing of drugs targeting yap-tead functions, file e31e124d-9360-987f-e053-3705fe0a095a
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297
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Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies, file e31e124d-4603-987f-e053-3705fe0a095a
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241
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Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology, file e31e124b-a0f6-987f-e053-3705fe0a095a
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184
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Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum, file e31e124b-21af-987f-e053-3705fe0a095a
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181
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Involvement of epigenetic modification of TERT promoter in response to all-trans retinoic acid in ovarian cancer cell lines, file e31e124d-bc84-987f-e053-3705fe0a095a
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177
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Anticancer activity of green tea polyphenols in prostate gland, file e31e124b-21b1-987f-e053-3705fe0a095a
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170
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Mitostatin Is Down-Regulated in Human Prostate Cancer and Suppresses the Invasive Phenotype of Prostate Cancer Cells, file e31e124b-2744-987f-e053-3705fe0a095a
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169
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The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines, file e31e124d-da2d-987f-e053-3705fe0a095a
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156
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Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer, file e31e124d-83f4-987f-e053-3705fe0a095a
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151
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Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells, file e31e124e-8b64-987f-e053-3705fe0a095a
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143
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A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells, file e31e124e-3af2-987f-e053-3705fe0a095a
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140
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Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy, file e31e124e-976e-987f-e053-3705fe0a095a
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129
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Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth, file e31e124d-ca31-987f-e053-3705fe0a095a
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127
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Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma, file 115add2d-5a73-42f8-b973-dd6d459b310d
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126
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Structural bases for the synergistic inhibition of human thymidylate synthase and ovarian cancer cell growth by drug combinations, file e31e124f-9c9d-987f-e053-3705fe0a095a
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76
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Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth, file e31e124f-91d0-987f-e053-3705fe0a095a
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43
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Integrating MS proteomics in the Medicinal Chemistry pipeline as powerful tool to overcome drug resistance issues in colorectal cancer, file eec0b667-180d-4630-ad4b-35a4a08cd9f3
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30
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Telomere Dysfunction Is Associated with Altered {DNA} Organization in Trichoplein/Tchp/Mitostatin ({TpMs}) Depleted Cells, file 45facfef-f67f-44e2-a375-fc100ab51892
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26
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pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells, file e31e1250-700f-987f-e053-3705fe0a095a
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25
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Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma, file 2ddbc408-4788-4c10-b0d4-ea4913085e81
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24
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A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties, file a6638a6a-bdcc-4203-8baf-385dd3872252
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24
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The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines, file e31e124d-e59b-987f-e053-3705fe0a095a
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23
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Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme, file e31e1250-0e2a-987f-e053-3705fe0a095a
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19
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A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells, file e31e124e-4716-987f-e053-3705fe0a095a
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18
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Targeting the Interplay of Independent Cellular Pathways and Immunity: A Challenge in Cancer Immunotherapy, file d1de4bd3-4c52-4594-9b3a-35dfddad01ea
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17
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LC-MS serum proteomics reveals a panel of proteins prognostic of positive responsiveness to bevacizumab therapy in late-stages ovarian cancer patients, file f692143a-b58e-4062-a1a3-947796ac06ce
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17
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Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth, file a2cae1de-bd1b-426b-91e9-1b996303dd0b
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16
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Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles, file 13f336c6-8fa5-4469-9fbf-02448430cda9
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15
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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases, file e31e124f-2ee9-987f-e053-3705fe0a095a
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15
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Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth, file aa21c5db-c206-459d-83d7-a5a0a3c06e02
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13
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Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library, file cd6e45e3-17cf-4847-a275-f01c5213e6e5
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12
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Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase, file 0ca67a23-2652-4924-b376-42980df36080
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9
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Precision medicine through proteomics studies in drug resistant colorectal cancer, file 8c5009ef-314b-4e85-87b5-891ec2747a91
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9
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Development of a sensitive biochemical tool to assess the expression levels of recombinant ectopic proteins in in vitro engineered cellular systems, file a70353c0-b6be-4929-93f2-b44e59752349
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8
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The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression, file e31e124b-2a1a-987f-e053-3705fe0a095a
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5
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Structural insight into YAP-TEAD4 protein-protein interactions as target for cancer treatment, file 8922c0fe-8a37-40ff-b4fb-b5a72955e768
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4
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Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery, file e31e124b-30c0-987f-e053-3705fe0a095a
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4
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Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides, file e31e124b-3cea-987f-e053-3705fe0a095a
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4
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Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones?, file e31e124c-bb95-987f-e053-3705fe0a095a
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4
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ANTICANCER DRUGS, file e31e124d-a391-987f-e053-3705fe0a095a
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3
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Successful prediction of prostate cancer recurrence by gene profiling in combination with clinical data: a 5-year follow-up study., file e31e124b-1ec5-987f-e053-3705fe0a095a
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2
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Clusterin decreases oxidative stress in lung fibroblasts exposed to cigarette smoke, file e31e124b-1f34-987f-e053-3705fe0a095a
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2
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pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells, file e31e124d-76c3-987f-e053-3705fe0a095a
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2
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Exploiting the Optical Tweezer technology to reveal thymidylate synthase
interactions with its consensus mRNA, file afa6beb3-cdda-4ed8-ad57-9c6c8e7bc197
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1
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Spermidine/spermine N1-acetyltransferase transient over-expression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin, file e31e124a-9dfb-987f-e053-3705fe0a095a
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1
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The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain., file e31e124a-a059-987f-e053-3705fe0a095a
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1
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Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor, file e31e124b-1ec2-987f-e053-3705fe0a095a
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1
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Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin, file e31e124b-1ed2-987f-e053-3705fe0a095a
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1
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Clusterin (SGP-2, ApoJ) expression is downregulated in low- and high-grade human prostate cancer, file e31e124b-1ed9-987f-e053-3705fe0a095a
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1
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Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells, file e31e124b-21b8-987f-e053-3705fe0a095a
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1
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MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer, file e31e124b-24b5-987f-e053-3705fe0a095a
|
1
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Optimization of Peptides That Target Human Thymidylate Synthase
to Inhibit Ovarian Cancer Cell Growth, file e31e124b-3ce9-987f-e053-3705fe0a095a
|
1
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Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance, file e31e124f-488f-987f-e053-3705fe0a095a
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1
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| Totale |
3.272 |
