FRANCHINI, Silvia
 Distribuzione geografica
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Continente #
NA - Nord America 7.635
EU - Europa 5.217
AS - Asia 850
AF - Africa 16
SA - Sud America 15
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 6
Totale 13.747
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Nazione #
US - Stati Uniti d'America 7.571
GB - Regno Unito 1.619
IT - Italia 1.153
SE - Svezia 853
DE - Germania 475
CN - Cina 372
UA - Ucraina 216
HK - Hong Kong 194
FR - Francia 188
FI - Finlandia 159
BE - Belgio 127
TR - Turchia 127
BG - Bulgaria 112
IE - Irlanda 76
RU - Federazione Russa 69
CA - Canada 52
IN - India 52
PL - Polonia 46
RO - Romania 39
LT - Lituania 31
SG - Singapore 31
IR - Iran 23
CH - Svizzera 11
NO - Norvegia 11
IL - Israele 10
JP - Giappone 9
NL - Olanda 9
BR - Brasile 7
CI - Costa d'Avorio 6
EU - Europa 6
KR - Corea 6
MX - Messico 6
NZ - Nuova Zelanda 6
PK - Pakistan 6
PT - Portogallo 5
VN - Vietnam 5
CL - Cile 4
MY - Malesia 4
BZ - Belize 3
CO - Colombia 3
LU - Lussemburgo 3
TW - Taiwan 3
TZ - Tanzania 3
UG - Uganda 3
AE - Emirati Arabi Uniti 2
AU - Australia 2
BA - Bosnia-Erzegovina 2
CZ - Repubblica Ceca 2
DK - Danimarca 2
GR - Grecia 2
NG - Nigeria 2
PR - Porto Rico 2
AL - Albania 1
AT - Austria 1
BD - Bangladesh 1
BH - Bahrain 1
EG - Egitto 1
ES - Italia 1
HU - Ungheria 1
ID - Indonesia 1
IS - Islanda 1
KZ - Kazakistan 1
PH - Filippine 1
RS - Serbia 1
SA - Arabia Saudita 1
SC - Seychelles 1
SK - Slovacchia (Repubblica Slovacca) 1
TT - Trinidad e Tobago 1
VE - Venezuela 1
Totale 13.747
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Città #
Southend 1.253
Fairfield 811
Chandler 758
Woodbridge 606
Ann Arbor 578
Ashburn 479
Houston 478
Nyköping 463
Jacksonville 458
Dearborn 379
Seattle 353
Wilmington 312
Cambridge 279
Modena 207
New York 192
Hong Kong 174
Beijing 139
Brussels 125
Sofia 112
Princeton 99
Eugene 97
Helsinki 94
San Diego 85
Izmir 78
Dublin 75
Fremont 61
Des Moines 60
Frankfurt am Main 53
Redwood City 50
Bremen 42
Kraków 39
Munich 39
Milan 38
London 36
Grafing 32
Boardman 30
Shenzhen 30
Bologna 28
Shanghai 28
Norwalk 26
Toronto 26
Verona 25
Philadelphia 22
West Jordan 22
Saint Petersburg 21
Falls Church 20
Rome 20
Milwaukee 19
Augusta 18
Hefei 18
Horia 18
Kunming 16
Los Angeles 15
Parma 14
Zanjan 13
Leawood 11
San Jose 11
Jerusalem 10
Romainville 10
San Francisco 10
San Mateo 10
Umeå 10
Chiswick 9
Kilburn 9
Las Vegas 9
Napoli 9
Ottawa 9
Paris 9
Pasadena 9
Pavia 9
Tromsø 9
Auburn Hills 8
Catania 8
Guangzhou 8
Mcallen 8
Nanjing 8
Reggio Emilia 8
Trieste 8
Turin 8
Brooklyn 7
Montréal 7
Nuremberg 7
Old Bridge 7
Phoenix 7
Timisoara 7
Tulsa 7
Abidjan 6
Albuquerque 6
Andover 6
Auckland 6
Avellino 6
Hounslow 6
Jinan 6
Morgantown 6
Negrar 6
St Petersburg 6
Ancona 5
Camerino 5
Dong Ket 5
Elora 5
Totale 9.909
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Nome #
(2,2-difenil-[1,3]-diossolan-4ilmetil)-(3-fenil-propil)-ammina: nuovo agonista parziale del recettore serotoninergico 5-HT1A 493
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity 346
1,2,4-Benzothiadiazine derivatives as alpha(1) and 5-HT1A receptor ligands 311
1,3-Dioxolane-Based Ligands as a Novel Class of Alpha1-Adrenoceptor Antagonists 309
1,3-Dioxolane-Based Ligands as Rigid Analogues ofNaftopidil: Structure–Affinity/Activity Relationships at a1and 5-HT1A Receptors 288
1,3-Dioxolane-Based Ligands Incorporating a Lactam or Imide moiety: Structure-Affinity/Activity Relationship at alpha1–Adrenoceptor subtypes and at 5-HT1A Receptors 272
1,3-dioxolane-based ligands in the search for alpha1-adrenergic antagonists. 269
1,3-Diossolani e analoghi aperti come nuovi ligandi per il recettore Sigma 260
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 241
A New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside Analogues 223
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 217
Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry 214
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 208
Structure-Activity Relationship within a new series of σ1 and σ2 receptor ligands: identification of a novel σ2R agonist (BS148) with selective toxicity against metastatic melanoma 199
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 197
Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides 193
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding. 192
Discovery Of New Sigma-2 Receptor Agonist Endowed With Antiproliferative Activity 189
1-(1,4-Dioxa-spiro[4.5]dec-2ylmethyl)-4-(2-methoxy-phenyl)-piperazine: SAR at alpha1 and 5-HT1A Receptors. 186
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: A ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 184
Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside Analogues 183
Cell-cycle Inhibition by Helicobacter pylori L-Asparaginase 183
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase. 179
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1 178
Discovery of a new series of 5-HT1A receptor agonists 177
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1and 5-HT1Areceptor ligand: an in vitro and computational study 177
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors 176
Development, Validation and Application of an LC-MS/MS Bioanalytical Method for the Quantification of GF449, A Novel 5-HT1A Agonist, in Rat Plasma and Brain. 176
Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane 175
Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents 174
(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenylpropyl)-amine: a Potent and Selective 5-HT1A Receptor Agonist 173
Synthesis and Antimuscarinic Activity of Some Ether- and Thioether-Bearing 1,3-dioxolanes and Related Sulfoxides and Sulfones 171
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 170
Allosteric Inhibition of human Thymidylate Synthase. 168
ANTICANCER DRUGS 166
Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs) 165
Cloning and purification of the Rainbow Trout fifth component of complement (C5). 155
Further insights into the pharmacology of the human Trace Amine-Associated Receptors: discovery of novel ligands for TAAR1 by a virtual screening approach 154
Multitarget 1,4-Dioxane Compounds Combining Favorable D 2 -like and 5-HT 1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 153
Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]dimethyl-amine 152
Characterization of factor H-like molecules in Rainbow Trout 152
Insights into the structure of the Human TAAR5 receptor: a computational study 150
Alternative strategies in medicinal chemistry to face drug resistance in anticancer therapy. 147
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 146
Synthesis, biological evaluation and molecular modelling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 145
MALDI-TOF MS as a tool for rapid Identification of Low Protein Affinity Drug Fragments. 143
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury 142
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 140
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 138
Synthesis and antimuscarinic activity of some N-(4-dimethylaminomethyl-2-phenyl-1,3)dioxolan-2-ylmethyl)lactam methiodides 133
Discovery of a new 5-HT1A receptor agonist, acting ‘in vivo’ in a rat model of anxiety and depression 132
Merging disulphide bonds for drug design Interfering with a cancer key protein 130
Identification of a Potent and Selective 5-HT1AReceptor Agonist with In Vitro and In Vivo Antinociceptive Activity 127
Derivati 1,3-diossanici come ligandi alpha1 adrenergici e 5-HT1A serotoninergici. 124
Scouting Sigma Receptor Ligands As New Tools For The Treatment Of Neurodegenerative Diseases And Cancer 124
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 124
Synthesis and pharmacological evaluation of 1-benzylpiperazine and 4-benzylpiperidine as potent sigma ligands. 123
Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents 120
Structure Activity Relationships at 5-HT1A receptors within a novel series of 4-alkyl-1-arylpiperazine derivatives 119
Synthesis and biological evaluations of 4-alkyl-1-Arylpiperazine derivatives: SAR at 5-HT1A and 1 –Adrenoreceptor 119
Kinetic Analysis of the Interactions of Complement Receptor 2(CR2, CD21) with Its Ligands C3d, iC3b, and the EBVGlycoprotein gp350/220 118
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT 1A receptor agonists for CNS disorders and neuropathic pain 118
Synthesis, Biological Evaluation and Docking Studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at Adrenergic alpha1- and Serotonine 5-HT1A receptors 117
Benzothiadiazine derivatives as 1 and 5-HT1A receptor ligands. 117
Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands 116
Molecular modeling and biological studies show that some μ-opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors 113
Insights into the structure and pharmacology of Trace Amine-Associated Receptor 1 (TAAR1), a new target for medicinal chemistry 104
Effect of aromatic substitution on antimuscarinic activity of 2-phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dioxolanes 102
Heteroarylphenoxyethyl amine as selective 5-HT1A receptor ligands: synthesis and structure-activity ralationship studies. 102
Novel monoclonal antibodies against mouse C3 interfering with complement activation: Description of fine specificity and applications to various immunoassays 102
Ring opening effect at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel class of 1,3-Dioxolane-based ligands 99
Nuova Serie di Ligandi Sigma a Struttura Piperazinica e Piperidinica 93
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 92
Investigation within a new series of heterocyclic biaryl piperazines acting at 5-HT1A serotoninergic receptors 91
Structure Activity Relationship at 5-HT1A receptors within a novel series of spiro-1,3-Dioxolane-based ligands 88
Structure-Activity Relationships at alpha1-Adrenoceptor Subtypes within a New Series of 1,3-Dioxolane Derivatives 86
Derivati 1,3-Diossanici come Antagonisti Muscarinici 85
Risoluzione della miscela racemica del (±)-(2,2-difenil-[1,3]diossolan-4-ilmetil)-(2-fenossi-etil) ammina, potente antagonista alpha1 adrenergico, 84
Effect of the rigidification of propranolol, a mixed β-adrenoceptor and 5-HT1AR antagonist 83
DAT atypical inhibitors as novel antipsychotic drugs 83
Monoclonal antibodies against mouse C3-fragments - a new repertoire of reagents targeting C3-mediated functions 79
Relazioni struttura-attività in una nuova serie di ligandi alpha1-adrenergici e 5-HT1A serotoninergici a struttura 2,2-difenil-[1,3]diossolanica 79
The role of a newly-identified heterologous crosstalk between G-Protein coupled seven trasmembrane span receptors- Chemokine Receptor CXCR4 and Complement C3aR in Human hemato-lymphopoiesis and Innate Immunity 77
SAR at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel series of 1,3-Dioxolane-based ligands. 74
Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group 72
Constrained 1,4-dialkylpiperazines as monoamine transporters inhibitors for cocaine-related abuse 65
A novel role of complement: mice deficient in the fifth componenet of complement (C5) exhibit impaired liver regeneration. 64
IDENTIFICATION OF POTENT 1,3-DIOXOLANE-BASED 5-HT1A RECEPTOR AGONISTS FOR THE TREATMENTS OF CNS DISORDERS AND PAIN 60
Sintesi e attivita' farmacologica di alcuni N-(1,3-diossolan-2-il-metil)-lattami 58
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 57
BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting 57
Pharmacological properties and biochemical mechanisms of μ-opioid receptor ligands might be due to different binding poses: MD studies 54
Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands 38
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer 29
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents 18
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol 2
Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status 1
Totale 13.951
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Categoria #
all - tutte 48.249
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 48.249
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019523 0 0 0 0 0 0 0 0 0 0 310 213
2019/20202.505 216 127 74 148 294 355 417 239 252 92 150 141
2020/20212.520 252 101 183 181 294 199 268 232 187 338 186 99
2021/20221.972 111 170 142 139 110 149 79 105 268 135 328 236
2022/20232.512 373 302 179 253 270 342 79 189 301 73 94 57
2023/20241.443 42 91 180 144 409 142 97 196 34 69 39 0
Totale 13.951