FRANCHINI, Silvia
 Distribuzione geografica
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Continente #
NA - Nord America 11.942
EU - Europa 7.565
AS - Asia 4.631
SA - Sud America 698
AF - Africa 80
OC - Oceania 34
Continente sconosciuto - Info sul continente non disponibili 7
Totale 24.957
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Nazione #
US - Stati Uniti d'America 11.755
GB - Regno Unito 2.009
CN - Cina 1.524
IT - Italia 1.438
SG - Singapore 1.350
DE - Germania 1.051
SE - Svezia 1.009
HK - Hong Kong 686
BR - Brasile 585
FI - Finlandia 450
RU - Federazione Russa 412
VN - Vietnam 261
UA - Ucraina 239
FR - Francia 214
TR - Turchia 192
BE - Belgio 139
KR - Corea 135
IN - India 125
BG - Bulgaria 117
CA - Canada 111
NL - Olanda 97
PL - Polonia 91
IE - Irlanda 82
ID - Indonesia 69
MX - Messico 51
JP - Giappone 49
RO - Romania 47
LT - Lituania 42
BD - Bangladesh 38
IR - Iran 32
AR - Argentina 30
EC - Ecuador 27
ES - Italia 27
NZ - Nuova Zelanda 26
AT - Austria 23
ZA - Sudafrica 22
IL - Israele 21
IQ - Iraq 20
PK - Pakistan 16
TW - Taiwan 16
CH - Svizzera 15
SA - Arabia Saudita 15
AE - Emirati Arabi Uniti 14
NO - Norvegia 13
CO - Colombia 12
KE - Kenya 12
CZ - Repubblica Ceca 11
EG - Egitto 11
PY - Paraguay 11
CL - Cile 10
VE - Venezuela 10
PE - Perù 9
PT - Portogallo 9
AU - Australia 8
UZ - Uzbekistan 8
CI - Costa d'Avorio 7
JO - Giordania 7
KZ - Kazakistan 7
EU - Europa 6
AZ - Azerbaigian 5
LU - Lussemburgo 5
MA - Marocco 5
MY - Malesia 5
TH - Thailandia 5
BH - Bahrain 4
DZ - Algeria 4
NG - Nigeria 4
PH - Filippine 4
BY - Bielorussia 3
BZ - Belize 3
CR - Costa Rica 3
DK - Danimarca 3
LB - Libano 3
SN - Senegal 3
TZ - Tanzania 3
UG - Uganda 3
AM - Armenia 2
AO - Angola 2
BA - Bosnia-Erzegovina 2
CU - Cuba 2
DM - Dominica 2
EE - Estonia 2
GR - Grecia 2
GT - Guatemala 2
HN - Honduras 2
HR - Croazia 2
HU - Ungheria 2
IS - Islanda 2
LK - Sri Lanka 2
MM - Myanmar 2
NI - Nicaragua 2
NP - Nepal 2
PA - Panama 2
PR - Porto Rico 2
QA - Qatar 2
RS - Serbia 2
SC - Seychelles 2
SK - Slovacchia (Repubblica Slovacca) 2
TT - Trinidad e Tobago 2
UY - Uruguay 2
Totale 24.936
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Città #
Southend 1.253
Santa Clara 1.128
Ashburn 909
Singapore 824
Fairfield 811
Chandler 758
Hong Kong 656
Woodbridge 606
Ann Arbor 578
Munich 536
Hefei 505
Houston 491
Nyköping 463
Jacksonville 460
Dearborn 379
Seattle 364
London 358
Chicago 348
Wilmington 340
Helsinki 320
New York 314
Beijing 297
Cambridge 279
Los Angeles 261
Dallas 236
Modena 236
Brussels 137
Salt Lake City 125
Seoul 121
Sofia 116
Princeton 99
Ho Chi Minh City 98
Eugene 97
Council Bluffs 88
Frankfurt am Main 86
San Diego 85
Milan 82
Dublin 81
Izmir 79
Elk Grove Village 75
Moscow 73
Tampa 66
Fremont 63
Des Moines 62
Amsterdam 59
Buffalo 56
Hanoi 55
The Dalles 52
Bologna 50
Redwood City 50
Shanghai 48
São Paulo 47
Jakarta 45
Toronto 44
Bremen 42
Yalova 41
Tokyo 40
Kraków 39
Boardman 38
Warsaw 38
Shenzhen 35
Turku 33
Grafing 32
Sterling 31
Phoenix 29
Boston 27
Auckland 26
Norwalk 26
Orem 26
Verona 26
Lancaster 25
Mexico City 25
Philadelphia 24
Rome 24
Columbus 23
Mumbai 23
Jyväskylä 22
Milwaukee 22
Montreal 22
Sochi 22
West Jordan 22
Augusta 21
Brooklyn 21
Guangzhou 21
Parma 21
Saint Petersburg 21
Falls Church 20
Kent 20
Denver 19
Reggio Emilia 19
Atlanta 18
Hillsboro 18
Horia 18
Ottawa 18
San Francisco 18
Stockholm 18
Nuremberg 17
Chennai 16
Kunming 16
Dulles 15
Totale 16.987
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Nome #
1,2,4-Benzothiadiazine derivatives as alpha(1) and 5-HT1A receptor ligands 724
1,3-Dioxolane-Based Ligands Incorporating a Lactam or Imide moiety: Structure-Affinity/Activity Relationship at alpha1–Adrenoceptor subtypes and at 5-HT1A Receptors 698
(2,2-difenil-[1,3]-diossolan-4ilmetil)-(3-fenil-propil)-ammina: nuovo agonista parziale del recettore serotoninergico 5-HT1A 604
1,3-Diossolani e analoghi aperti come nuovi ligandi per il recettore Sigma 600
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity 518
1,3-Dioxolane-Based Ligands as a Novel Class of Alpha1-Adrenoceptor Antagonists 470
1,3-Dioxolane-Based Ligands as Rigid Analogues ofNaftopidil: Structure–Affinity/Activity Relationships at a1and 5-HT1A Receptors 440
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1and 5-HT1Areceptor ligand: an in vitro and computational study 411
(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenylpropyl)-amine: a Potent and Selective 5-HT1A Receptor Agonist 407
1,3-dioxolane-based ligands in the search for alpha1-adrenergic antagonists. 397
Discovery of a new 5-HT1A receptor agonist, acting ‘in vivo’ in a rat model of anxiety and depression 389
Synthesis and pharmacological evaluation of 1-benzylpiperazine and 4-benzylpiperidine as potent sigma ligands. 382
Development, Validation and Application of an LC-MS/MS Bioanalytical Method for the Quantification of GF449, A Novel 5-HT1A Agonist, in Rat Plasma and Brain. 367
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 351
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury 347
Cloning and purification of the Rainbow Trout fifth component of complement (C5). 340
A New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside Analogues 334
Discovery Of New Sigma-2 Receptor Agonist Endowed With Antiproliferative Activity 323
Synthesis and biological evaluations of 4-alkyl-1-Arylpiperazine derivatives: SAR at 5-HT1A and 1 –Adrenoreceptor 320
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 317
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 308
1-(1,4-Dioxa-spiro[4.5]dec-2ylmethyl)-4-(2-methoxy-phenyl)-piperazine: SAR at alpha1 and 5-HT1A Receptors. 307
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 303
Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands 297
Allosteric Inhibition of human Thymidylate Synthase. 296
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors 292
Structure-Activity Relationship within a new series of σ1 and σ2 receptor ligands: identification of a novel σ2R agonist (BS148) with selective toxicity against metastatic melanoma 291
Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside Analogues 290
Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry 287
ANTICANCER DRUGS 282
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT 1A receptor agonists for CNS disorders and neuropathic pain 282
Discovery of a new series of 5-HT1A receptor agonists 281
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 281
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding 281
Alternative strategies in medicinal chemistry to face drug resistance in anticancer therapy. 272
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1 270
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase. 263
Cell-cycle Inhibition by Helicobacter pylori L-Asparaginase 257
Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides 256
Synthesis and antimuscarinic activity of some N-(4-dimethylaminomethyl-2-phenyl-1,3)dioxolan-2-ylmethyl)lactam methiodides 248
Synthesis and Antimuscarinic Activity of Some Ether- and Thioether-Bearing 1,3-dioxolanes and Related Sulfoxides and Sulfones 248
Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs) 247
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 247
Novel monoclonal antibodies against mouse C3 interfering with complement activation: Description of fine specificity and applications to various immunoassays 246
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: A ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 239
MALDI-TOF MS as a tool for rapid Identification of Low Protein Affinity Drug Fragments. 238
BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting 231
Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents 230
Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane 230
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 220
Further insights into the pharmacology of the human Trace Amine-Associated Receptors: discovery of novel ligands for TAAR1 by a virtual screening approach 218
Scouting Sigma Receptor Ligands As New Tools For The Treatment Of Neurodegenerative Diseases And Cancer 216
Synthesis, biological evaluation and molecular modelling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 214
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 213
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 211
DAT atypical inhibitors as novel antipsychotic drugs 211
Structure Activity Relationships at 5-HT1A receptors within a novel series of 4-alkyl-1-arylpiperazine derivatives 210
Derivati 1,3-diossanici come ligandi alpha1 adrenergici e 5-HT1A serotoninergici. 209
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer 207
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 206
Synthesis, Biological Evaluation and Docking Studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at Adrenergic alpha1- and Serotonine 5-HT1A receptors 203
Insights into the structure of the Human TAAR5 receptor: a computational study 203
Effect of the rigidification of propranolol, a mixed β-adrenoceptor and 5-HT1AR antagonist 203
Heteroarylphenoxyethyl amine as selective 5-HT1A receptor ligands: synthesis and structure-activity ralationship studies. 201
Benzothiadiazine derivatives as 1 and 5-HT1A receptor ligands. 200
Multitarget 1,4-Dioxane Compounds Combining Favorable D 2 -like and 5-HT 1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 200
Merging disulphide bonds for drug design Interfering with a cancer key protein 200
Identification of a Potent and Selective 5-HT1AReceptor Agonist with In Vitro and In Vivo Antinociceptive Activity 196
Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]dimethyl-amine 195
Kinetic Analysis of the Interactions of Complement Receptor 2(CR2, CD21) with Its Ligands C3d, iC3b, and the EBVGlycoprotein gp350/220 194
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 193
Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents 188
Investigation within a new series of heterocyclic biaryl piperazines acting at 5-HT1A serotoninergic receptors 185
Characterization of factor H-like molecules in Rainbow Trout 185
Ring opening effect at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel class of 1,3-Dioxolane-based ligands 173
Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group 172
Structure Activity Relationship at 5-HT1A receptors within a novel series of spiro-1,3-Dioxolane-based ligands 170
Derivati 1,3-Diossanici come Antagonisti Muscarinici 164
Insights into the structure and pharmacology of Trace Amine-Associated Receptor 1 (TAAR1), a new target for medicinal chemistry 164
Effect of aromatic substitution on antimuscarinic activity of 2-phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dioxolanes 161
Risoluzione della miscela racemica del (±)-(2,2-difenil-[1,3]diossolan-4-ilmetil)-(2-fenossi-etil) ammina, potente antagonista alpha1 adrenergico, 160
Molecular modeling and biological studies show that some μ-opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors 157
Relazioni struttura-attività in una nuova serie di ligandi alpha1-adrenergici e 5-HT1A serotoninergici a struttura 2,2-difenil-[1,3]diossolanica 153
A novel role of complement: mice deficient in the fifth componenet of complement (C5) exhibit impaired liver regeneration. 151
Constrained 1,4-dialkylpiperazines as monoamine transporters inhibitors for cocaine-related abuse 147
IDENTIFICATION OF POTENT 1,3-DIOXOLANE-BASED 5-HT1A RECEPTOR AGONISTS FOR THE TREATMENTS OF CNS DISORDERS AND PAIN 142
Nuova Serie di Ligandi Sigma a Struttura Piperazinica e Piperidinica 140
Synthesis and biological evaluation of Hsp90/HDAC6 dual inhibitors bearing a 2-amino-pyrrolopyrimidine and purine scaffold as potential anticancer drugs to treat prostate cancer 138
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents 135
Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands 133
1,3-Dithiolane as a Privileged Scaffold in Bioactive Derivatives: Chiral Resolution and Assignment of Absolute Configuration 128
Structure-Activity Relationships at alpha1-Adrenoceptor Subtypes within a New Series of 1,3-Dioxolane Derivatives 122
SAR at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel series of 1,3-Dioxolane-based ligands. 120
Monoclonal antibodies against mouse C3-fragments - a new repertoire of reagents targeting C3-mediated functions 117
The role of a newly-identified heterologous crosstalk between G-Protein coupled seven trasmembrane span receptors- Chemokine Receptor CXCR4 and Complement C3aR in Human hemato-lymphopoiesis and Innate Immunity 114
Sintesi e attivita' farmacologica di alcuni N-(1,3-diossolan-2-il-metil)-lattami 109
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol 99
TB62, A POTENT 5-HT1A SEROTONERGIC FULL AGONIST, ENDOWED WITH DUAL ANTINOCICEPTIVE AND ANXIOLITIC/ANTIDEPRESSANT ACTIVITY 98
Pharmacological properties and biochemical mechanisms of μ-opioid receptor ligands might be due to different binding poses: MD studies 92
Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status 91
Totale 25.170
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Categoria #
all - tutte 89.632
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 89.632
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.509 0 0 0 0 0 199 268 232 187 338 186 99
2021/20221.972 111 170 142 139 110 149 79 105 268 135 328 236
2022/20232.512 373 302 179 253 270 342 79 189 301 73 94 57
2023/20241.640 42 91 180 144 409 142 97 196 34 69 106 130
2024/20255.701 215 76 137 308 846 735 704 441 696 290 532 721
2025/20265.321 599 432 886 1.227 1.749 428 0 0 0 0 0 0
Totale 25.170