FRANCHINI, Silvia
 Distribuzione geografica
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Continente #
NA - Nord America 7.720
EU - Europa 5.308
AS - Asia 1.097
AF - Africa 16
SA - Sud America 15
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 6
Totale 14.170
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Nazione #
US - Stati Uniti d'America 7.650
GB - Regno Unito 1.628
IT - Italia 1.186
SE - Svezia 863
DE - Germania 485
CN - Cina 439
UA - Ucraina 216
FR - Francia 196
HK - Hong Kong 194
SG - Singapore 183
FI - Finlandia 159
BE - Belgio 128
TR - Turchia 127
BG - Bulgaria 112
IE - Irlanda 76
RU - Federazione Russa 70
CA - Canada 58
IN - India 56
PL - Polonia 46
RO - Romania 39
LT - Lituania 31
IR - Iran 23
NL - Olanda 21
ID - Indonesia 20
CH - Svizzera 12
JP - Giappone 11
NO - Norvegia 11
IL - Israele 10
BR - Brasile 7
CZ - Repubblica Ceca 7
CI - Costa d'Avorio 6
EU - Europa 6
KR - Corea 6
MX - Messico 6
NZ - Nuova Zelanda 6
PK - Pakistan 6
PT - Portogallo 5
VN - Vietnam 5
CL - Cile 4
MY - Malesia 4
TW - Taiwan 4
BZ - Belize 3
CO - Colombia 3
LU - Lussemburgo 3
TZ - Tanzania 3
UG - Uganda 3
AE - Emirati Arabi Uniti 2
AU - Australia 2
BA - Bosnia-Erzegovina 2
DK - Danimarca 2
ES - Italia 2
GR - Grecia 2
JO - Giordania 2
NG - Nigeria 2
PR - Porto Rico 2
AL - Albania 1
AT - Austria 1
BD - Bangladesh 1
BH - Bahrain 1
EG - Egitto 1
HU - Ungheria 1
IS - Islanda 1
KZ - Kazakistan 1
PH - Filippine 1
RS - Serbia 1
SA - Arabia Saudita 1
SC - Seychelles 1
SK - Slovacchia (Repubblica Slovacca) 1
TT - Trinidad e Tobago 1
VE - Venezuela 1
Totale 14.170
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Città #
Southend 1.253
Fairfield 811
Chandler 758
Woodbridge 606
Ann Arbor 578
Ashburn 493
Houston 478
Nyköping 463
Jacksonville 458
Dearborn 379
Seattle 354
Wilmington 312
Cambridge 279
Modena 213
New York 192
Hong Kong 174
Beijing 145
Brussels 126
Sofia 112
Princeton 99
Singapore 98
Eugene 97
Helsinki 94
San Diego 85
Izmir 78
Dublin 75
Fremont 61
Des Moines 60
Frankfurt am Main 58
Chicago 51
Redwood City 50
Bremen 42
Munich 41
Kraków 39
Milan 39
London 38
Boardman 36
Shanghai 33
Bologna 32
Grafing 32
Shenzhen 30
Norwalk 26
Toronto 26
Verona 25
Philadelphia 22
West Jordan 22
Saint Petersburg 21
Falls Church 20
Jakarta 20
Rome 20
Milwaukee 19
Parma 19
Augusta 18
Hefei 18
Horia 18
Kunming 16
Los Angeles 16
Amsterdam 15
Ottawa 15
Guangzhou 14
Zanjan 13
Leawood 11
Reggio Emilia 11
San Jose 11
Jerusalem 10
Romainville 10
San Francisco 10
San Mateo 10
Umeå 10
Chiswick 9
Kilburn 9
Las Vegas 9
Napoli 9
Paris 9
Pasadena 9
Pavia 9
Tromsø 9
Auburn Hills 8
Catania 8
Mcallen 8
Nanjing 8
Trieste 8
Turin 8
Brooklyn 7
Camerino 7
Montréal 7
Nuremberg 7
Old Bridge 7
Phoenix 7
Timisoara 7
Tulsa 7
Abidjan 6
Albuquerque 6
Andover 6
Auckland 6
Avellino 6
Hounslow 6
Jinan 6
Morgantown 6
Negrar 6
Totale 10.148
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Nome #
(2,2-difenil-[1,3]-diossolan-4ilmetil)-(3-fenil-propil)-ammina: nuovo agonista parziale del recettore serotoninergico 5-HT1A 497
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity 365
1,2,4-Benzothiadiazine derivatives as alpha(1) and 5-HT1A receptor ligands 324
1,3-Dioxolane-Based Ligands as a Novel Class of Alpha1-Adrenoceptor Antagonists 323
1,3-Dioxolane-Based Ligands as Rigid Analogues ofNaftopidil: Structure–Affinity/Activity Relationships at a1and 5-HT1A Receptors 293
1,3-Dioxolane-Based Ligands Incorporating a Lactam or Imide moiety: Structure-Affinity/Activity Relationship at alpha1–Adrenoceptor subtypes and at 5-HT1A Receptors 279
1,3-Diossolani e analoghi aperti come nuovi ligandi per il recettore Sigma 275
1,3-dioxolane-based ligands in the search for alpha1-adrenergic antagonists. 273
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 245
A New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside Analogues 227
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 221
Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry 216
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 210
Structure-Activity Relationship within a new series of σ1 and σ2 receptor ligands: identification of a novel σ2R agonist (BS148) with selective toxicity against metastatic melanoma 209
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 199
Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides 197
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding. 195
Discovery Of New Sigma-2 Receptor Agonist Endowed With Antiproliferative Activity 194
Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside Analogues 189
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: A ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 188
1-(1,4-Dioxa-spiro[4.5]dec-2ylmethyl)-4-(2-methoxy-phenyl)-piperazine: SAR at alpha1 and 5-HT1A Receptors. 187
Cell-cycle Inhibition by Helicobacter pylori L-Asparaginase 186
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase. 183
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1 181
Discovery of a new series of 5-HT1A receptor agonists 181
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1and 5-HT1Areceptor ligand: an in vitro and computational study 180
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors 179
Development, Validation and Application of an LC-MS/MS Bioanalytical Method for the Quantification of GF449, A Novel 5-HT1A Agonist, in Rat Plasma and Brain. 179
Allosteric Inhibition of human Thymidylate Synthase. 179
Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane 178
(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenylpropyl)-amine: a Potent and Selective 5-HT1A Receptor Agonist 177
Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents 177
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 177
Synthesis and Antimuscarinic Activity of Some Ether- and Thioether-Bearing 1,3-dioxolanes and Related Sulfoxides and Sulfones 173
ANTICANCER DRUGS 170
Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs) 168
Cloning and purification of the Rainbow Trout fifth component of complement (C5). 159
Multitarget 1,4-Dioxane Compounds Combining Favorable D 2 -like and 5-HT 1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 159
Further insights into the pharmacology of the human Trace Amine-Associated Receptors: discovery of novel ligands for TAAR1 by a virtual screening approach 155
Alternative strategies in medicinal chemistry to face drug resistance in anticancer therapy. 154
Insights into the structure of the Human TAAR5 receptor: a computational study 154
Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]dimethyl-amine 154
Characterization of factor H-like molecules in Rainbow Trout 152
Synthesis, biological evaluation and molecular modelling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 150
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 148
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury 147
MALDI-TOF MS as a tool for rapid Identification of Low Protein Affinity Drug Fragments. 146
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 142
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 140
Synthesis and antimuscarinic activity of some N-(4-dimethylaminomethyl-2-phenyl-1,3)dioxolan-2-ylmethyl)lactam methiodides 140
Discovery of a new 5-HT1A receptor agonist, acting ‘in vivo’ in a rat model of anxiety and depression 137
Merging disulphide bonds for drug design Interfering with a cancer key protein 132
Identification of a Potent and Selective 5-HT1AReceptor Agonist with In Vitro and In Vivo Antinociceptive Activity 131
Scouting Sigma Receptor Ligands As New Tools For The Treatment Of Neurodegenerative Diseases And Cancer 129
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 127
Synthesis and pharmacological evaluation of 1-benzylpiperazine and 4-benzylpiperidine as potent sigma ligands. 126
Derivati 1,3-diossanici come ligandi alpha1 adrenergici e 5-HT1A serotoninergici. 125
Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents 124
Structure Activity Relationships at 5-HT1A receptors within a novel series of 4-alkyl-1-arylpiperazine derivatives 123
Kinetic Analysis of the Interactions of Complement Receptor 2(CR2, CD21) with Its Ligands C3d, iC3b, and the EBVGlycoprotein gp350/220 121
Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands 121
Synthesis and biological evaluations of 4-alkyl-1-Arylpiperazine derivatives: SAR at 5-HT1A and 1 –Adrenoreceptor 121
Benzothiadiazine derivatives as 1 and 5-HT1A receptor ligands. 121
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT 1A receptor agonists for CNS disorders and neuropathic pain 120
Synthesis, Biological Evaluation and Docking Studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at Adrenergic alpha1- and Serotonine 5-HT1A receptors 118
Molecular modeling and biological studies show that some μ-opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors 117
Insights into the structure and pharmacology of Trace Amine-Associated Receptor 1 (TAAR1), a new target for medicinal chemistry 106
Effect of aromatic substitution on antimuscarinic activity of 2-phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dioxolanes 104
Heteroarylphenoxyethyl amine as selective 5-HT1A receptor ligands: synthesis and structure-activity ralationship studies. 104
Novel monoclonal antibodies against mouse C3 interfering with complement activation: Description of fine specificity and applications to various immunoassays 103
Ring opening effect at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel class of 1,3-Dioxolane-based ligands 102
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 99
Nuova Serie di Ligandi Sigma a Struttura Piperazinica e Piperidinica 97
Investigation within a new series of heterocyclic biaryl piperazines acting at 5-HT1A serotoninergic receptors 93
Structure Activity Relationship at 5-HT1A receptors within a novel series of spiro-1,3-Dioxolane-based ligands 91
Derivati 1,3-Diossanici come Antagonisti Muscarinici 90
DAT atypical inhibitors as novel antipsychotic drugs 89
Structure-Activity Relationships at alpha1-Adrenoceptor Subtypes within a New Series of 1,3-Dioxolane Derivatives 88
Effect of the rigidification of propranolol, a mixed β-adrenoceptor and 5-HT1AR antagonist 87
Risoluzione della miscela racemica del (±)-(2,2-difenil-[1,3]diossolan-4-ilmetil)-(2-fenossi-etil) ammina, potente antagonista alpha1 adrenergico, 86
Monoclonal antibodies against mouse C3-fragments - a new repertoire of reagents targeting C3-mediated functions 81
Relazioni struttura-attività in una nuova serie di ligandi alpha1-adrenergici e 5-HT1A serotoninergici a struttura 2,2-difenil-[1,3]diossolanica 81
The role of a newly-identified heterologous crosstalk between G-Protein coupled seven trasmembrane span receptors- Chemokine Receptor CXCR4 and Complement C3aR in Human hemato-lymphopoiesis and Innate Immunity 79
Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group 78
SAR at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel series of 1,3-Dioxolane-based ligands. 77
Constrained 1,4-dialkylpiperazines as monoamine transporters inhibitors for cocaine-related abuse 70
BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting 68
A novel role of complement: mice deficient in the fifth componenet of complement (C5) exhibit impaired liver regeneration. 68
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 66
IDENTIFICATION OF POTENT 1,3-DIOXOLANE-BASED 5-HT1A RECEPTOR AGONISTS FOR THE TREATMENTS OF CNS DISORDERS AND PAIN 65
Sintesi e attivita' farmacologica di alcuni N-(1,3-diossolan-2-il-metil)-lattami 58
Pharmacological properties and biochemical mechanisms of μ-opioid receptor ligands might be due to different binding poses: MD studies 55
Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands 45
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer 40
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents 24
Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status 8
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol 5
Totale 14.374
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Categoria #
all - tutte 54.139
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.139
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.289 0 127 74 148 294 355 417 239 252 92 150 141
2020/20212.520 252 101 183 181 294 199 268 232 187 338 186 99
2021/20221.972 111 170 142 139 110 149 79 105 268 135 328 236
2022/20232.512 373 302 179 253 270 342 79 189 301 73 94 57
2023/20241.640 42 91 180 144 409 142 97 196 34 69 106 130
2024/2025226 215 11 0 0 0 0 0 0 0 0 0 0
Totale 14.374