| Nome |
# |
|
Cell-cycle Inhibition by Helicobacter pylori L-Asparaginase, file e31e124a-ae93-987f-e053-3705fe0a095a
|
852
|
|
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives, file e31e124c-ca2e-987f-e053-3705fe0a095a
|
453
|
|
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5, file e31e124c-f744-987f-e053-3705fe0a095a
|
408
|
|
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists, file e31e124d-cb66-987f-e053-3705fe0a095a
|
334
|
|
A New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside Analogues, file e31e124a-d1b7-987f-e053-3705fe0a095a
|
259
|
|
Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides, file e31e124c-d6f5-987f-e053-3705fe0a095a
|
257
|
|
Structure-Activity Relationship within a new series of σ1 and σ2 receptor ligands: identification of a novel σ2R agonist (BS148) with selective toxicity against metastatic melanoma, file e31e124d-bdb4-987f-e053-3705fe0a095a
|
240
|
|
Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry, file e31e124b-0aa7-987f-e053-3705fe0a095a
|
203
|
|
Identification of a Potent and Selective 5-HT1AReceptor Agonist with In Vitro and In Vivo Antinociceptive Activity, file e31e124f-6187-987f-e053-3705fe0a095a
|
176
|
|
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity, file e31e124d-c284-987f-e053-3705fe0a095a
|
168
|
|
Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents, file e31e124f-6e79-987f-e053-3705fe0a095a
|
162
|
|
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: A ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands, file e31e124e-054b-987f-e053-3705fe0a095a
|
139
|
|
Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry, file e31e124c-ab80-987f-e053-3705fe0a095a
|
123
|
|
Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group, file e31e1250-0c78-987f-e053-3705fe0a095a
|
46
|
|
Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs), file e31e124e-ad2c-987f-e053-3705fe0a095a
|
40
|
|
Kinetic Analysis of the Interactions of Complement Receptor 2(CR2, CD21) with Its Ligands C3d, iC3b, and the EBVGlycoprotein gp350/220, file 43ac921e-028b-4363-a7b2-51963f4bdc8a
|
33
|
|
Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands, file 6dcb1b10-dcdb-40b3-95de-40e4886be028
|
24
|
|
DAT atypical inhibitors as novel antipsychotic drugs, file e31e124f-ce8b-987f-e053-3705fe0a095a
|
17
|
|
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth, file a2cae1de-bd1b-426b-91e9-1b996303dd0b
|
16
|
|
BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting, file afea1311-0924-45d5-84ea-1e83dd52f40c
|
14
|
|
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists, file e31e1250-65b0-987f-e053-3705fe0a095a
|
14
|
|
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer, file 5e2d8842-1f5f-4418-aa8c-fdbfb79d7113
|
13
|
|
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth, file aa21c5db-c206-459d-83d7-a5a0a3c06e02
|
13
|
|
A novel role of complement: mice deficient in the fifth componenet of complement (C5) exhibit impaired liver regeneration., file e31e124a-9891-987f-e053-3705fe0a095a
|
9
|
|
Constrained 1,4-dialkylpiperazines as monoamine transporters inhibitors for cocaine-related
abuse, file e31e124f-e7f8-987f-e053-3705fe0a095a
|
9
|
|
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents, file 53a95e5d-61e6-46d2-a3ea-debde3db1964
|
8
|
|
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors, file e31e124b-3adf-987f-e053-3705fe0a095a
|
7
|
|
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity, file e31e124f-7ba2-987f-e053-3705fe0a095a
|
6
|
|
Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status, file b9cec4ab-5784-488d-a7ee-133c11164951
|
5
|
|
Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands, file e31e124a-9d7d-987f-e053-3705fe0a095a
|
4
|
|
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol, file 3cd74c53-fb0e-449d-adea-88fa1111ad8d
|
3
|
|
Kinetic Analysis of the Interactions of Complement Receptor 2(CR2, CD21) with Its Ligands C3d, iC3b, and the EBVGlycoprotein gp350/220, file e31e124a-9890-987f-e053-3705fe0a095a
|
3
|
|
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1and 5-HT1Areceptor ligand: an in vitro and computational study, file e31e124b-0aa9-987f-e053-3705fe0a095a
|
3
|
|
ANTICANCER DRUGS, file e31e124d-a391-987f-e053-3705fe0a095a
|
3
|
|
Multitarget 1,4-Dioxane Compounds Combining Favorable D 2 -like and 5-HT 1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia, file e31e1250-3cbb-987f-e053-3705fe0a095a
|
3
|
|
Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside Analogues, file e31e124b-3fa3-987f-e053-3705fe0a095a
|
2
|
|
1,2,4-Benzothiadiazine derivatives as alpha(1) and 5-HT1A receptor ligands, file e31e124a-95bf-987f-e053-3705fe0a095a
|
1
|
|
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline, file e31e124a-95ce-987f-e053-3705fe0a095a
|
1
|
|
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury, file e31e124a-988e-987f-e053-3705fe0a095a
|
1
|
|
Novel monoclonal antibodies against mouse C3 interfering with complement activation: Description of fine specificity and applications to various immunoassays, file e31e124a-988f-987f-e053-3705fe0a095a
|
1
|
|
Cloning and purification of the Rainbow Trout fifth component of complement (C5)., file e31e124a-9892-987f-e053-3705fe0a095a
|
1
|
|
(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenylpropyl)-amine: a Potent and Selective 5-HT1A Receptor Agonist, file e31e124a-9be6-987f-e053-3705fe0a095a
|
1
|
|
1,3-Dioxolane-Based Ligands as Rigid Analogues ofNaftopidil: Structure–Affinity/Activity Relationships at a1and 5-HT1A Receptors, file e31e124a-9be7-987f-e053-3705fe0a095a
|
1
|
|
1,3-Dioxolane-Based Ligands Incorporating a Lactam or Imide moiety: Structure-Affinity/Activity Relationship at alpha1–Adrenoceptor subtypes and at 5-HT1A Receptors, file e31e124a-a229-987f-e053-3705fe0a095a
|
1
|
|
Further insights into the pharmacology of the human Trace Amine-Associated Receptors: discovery of novel ligands for TAAR1 by a virtual screening approach, file e31e124b-39b0-987f-e053-3705fe0a095a
|
1
|
|
Development, Validation and Application of an LC-MS/MS Bioanalytical Method for the Quantification of GF449, A Novel 5-HT1A Agonist, in Rat Plasma and Brain., file e31e124b-43d2-987f-e053-3705fe0a095a
|
1
|
|
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT 1A receptor agonists for CNS disorders and neuropathic pain, file e31e124d-c80a-987f-e053-3705fe0a095a
|
1
|
|
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives, file e31e124f-4997-987f-e053-3705fe0a095a
|
1
|
|
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists, file e31e124f-ca32-987f-e053-3705fe0a095a
|
1
|
| Totale |
4.082 |
