A series of 1,3-dioxolane-based ligands, bearing ether, thioether and related sulfoxide and sulfone functionalities, were synthsised and tested as potential muscarinic antagonists. The compounds display moderate to low affinity for the three receptor subtypes M1-M3, with some of them showing a significant selectivity for the M1-M3 over the M2 subtype.
Synthesis and Antimuscarinic Activity of Some Ether- and Thioether-Bearing 1,3-dioxolanes and Related Sulfoxides and Sulfones / L., Malmusi; Franchini, Silvia; Mucci, Adele; Schenetti, Luisa; U., Gulini; G., Marucci; Brasili, Livio. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 6:(1998), pp. 825-832.
Synthesis and Antimuscarinic Activity of Some Ether- and Thioether-Bearing 1,3-dioxolanes and Related Sulfoxides and Sulfones
FRANCHINI, Silvia;MUCCI, Adele;SCHENETTI, Luisa;BRASILI, Livio
1998
Abstract
A series of 1,3-dioxolane-based ligands, bearing ether, thioether and related sulfoxide and sulfone functionalities, were synthsised and tested as potential muscarinic antagonists. The compounds display moderate to low affinity for the three receptor subtypes M1-M3, with some of them showing a significant selectivity for the M1-M3 over the M2 subtype.
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