A series of 1,3-dioxolane-based ligands, having a lactam function were synthesized and tested as potential muscarinic antagonists. The compounds display moderate affinity for the three receptor subtypes M1-M3, with significant selectivity for the M1-M3 over the M2 subtype.
Synthesis and antimuscarinic activity of some N-(4-dimethylaminomethyl-2-phenyl-1,3)dioxolan-2-ylmethyl)lactam methiodides / L., Malmusi; Franchini, Silvia; Mucci, Adele; P., Angeli; U., Gulini; G., Marucci; Brasili, Livio. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - STAMPA. - 8:(1998), pp. 499-509.
Synthesis and antimuscarinic activity of some N-(4-dimethylaminomethyl-2-phenyl-1,3)dioxolan-2-ylmethyl)lactam methiodides
FRANCHINI, Silvia;MUCCI, Adele;BRASILI, Livio
1998
Abstract
A series of 1,3-dioxolane-based ligands, having a lactam function were synthesized and tested as potential muscarinic antagonists. The compounds display moderate affinity for the three receptor subtypes M1-M3, with significant selectivity for the M1-M3 over the M2 subtype.
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