A series of 1,3-oxathiolane-based nucleoside analogues 5-methyl substituted was synthesized and tested as potential antiviral agents. Structural characterization and C2-C4 / C2-C5 relative stereochemistry assignments were performed by NMR experiments. All tested isomers were found to be inactive and cytotoxic.
Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents / Franchini, Silvia; Tait, Annalisa; Sorbi, Claudia; Brasili, Livio. - In: MEDICINAL CHEMISTRY. - ISSN 1573-4064. - STAMPA. - 8:5(2012), pp. 769-778. [10.2174/157340612802084162]
Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents
FRANCHINI, Silvia;TAIT, Annalisa;SORBI, Claudia;BRASILI, Livio
2012
Abstract
A series of 1,3-oxathiolane-based nucleoside analogues 5-methyl substituted was synthesized and tested as potential antiviral agents. Structural characterization and C2-C4 / C2-C5 relative stereochemistry assignments were performed by NMR experiments. All tested isomers were found to be inactive and cytotoxic.
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