A series of 2-substituted 1,3-dioxolane ligands were synthesized and tested as muscarinic antagonists. The compounds display moderate to high affinity for the three receptor subtypes M-1-M-3, With some of them showing a modest selectivity for the M-1 subtype.
Effect of aromatic substitution on antimuscarinic activity of 2-phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dioxolanes / P., Angeli; Brasili, Livio; Franchini, Silvia; D., Giardina; U., Gulini; G., Marucci. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - STAMPA. - 9 (2):(1999), pp. 89-97.
Effect of aromatic substitution on antimuscarinic activity of 2-phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dioxolanes
BRASILI, Livio;FRANCHINI, Silvia;
1999
Abstract
A series of 2-substituted 1,3-dioxolane ligands were synthesized and tested as muscarinic antagonists. The compounds display moderate to high affinity for the three receptor subtypes M-1-M-3, With some of them showing a modest selectivity for the M-1 subtype.
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