: Alpha oscillations are a distinctive feature of the awake resting state of the human brain. However, their functional role in resting-state neuronal dynamics remains poorly understood. Here we show that, during resting wakefulness, alpha oscillations drive an alternation of attenuation and amplification bouts in neural activity. Our analysis indicates that inhibition is activated in pulses that last for a single alpha cycle and gradually suppress neural activity, while excitation is successively enhanced over a few alpha cycles to amplify neural activity. Furthermore, we show that long-term alpha amplitude fluctuations-the "waxing and waning" phenomenon-are an attenuation-amplification mechanism described by a power-law decay of the activity rate in the "waning" phase. Importantly, we do not observe such dynamics during non-rapid eye movement (NREM) sleep with marginal alpha oscillations. The results suggest that alpha oscillations modulate neural activity not only through pulses of inhibition (pulsed inhibition hypothesis) but also by timely enhancement of excitation (or disinhibition).

Beyond pulsed inhibition: Alpha oscillations modulate attenuation and amplification of neural activity in the awake resting state / Lombardi, Fabrizio; Herrmann, Hans J; Parrino, Liborio; Plenz, Dietmar; Scarpetta, Silvia; Vaudano, Anna Elisabetta; de Arcangelis, Lucilla; Shriki, Oren. - In: CELL REPORTS. - ISSN 2211-1247. - 42:10(2023), pp. 113162-113163. [10.1016/j.celrep.2023.113162]

Beyond pulsed inhibition: Alpha oscillations modulate attenuation and amplification of neural activity in the awake resting state

Vaudano, Anna Elisabetta;
2023

Abstract

: Alpha oscillations are a distinctive feature of the awake resting state of the human brain. However, their functional role in resting-state neuronal dynamics remains poorly understood. Here we show that, during resting wakefulness, alpha oscillations drive an alternation of attenuation and amplification bouts in neural activity. Our analysis indicates that inhibition is activated in pulses that last for a single alpha cycle and gradually suppress neural activity, while excitation is successively enhanced over a few alpha cycles to amplify neural activity. Furthermore, we show that long-term alpha amplitude fluctuations-the "waxing and waning" phenomenon-are an attenuation-amplification mechanism described by a power-law decay of the activity rate in the "waning" phase. Importantly, we do not observe such dynamics during non-rapid eye movement (NREM) sleep with marginal alpha oscillations. The results suggest that alpha oscillations modulate neural activity not only through pulses of inhibition (pulsed inhibition hypothesis) but also by timely enhancement of excitation (or disinhibition).
2023
42
10
113162
113163
Beyond pulsed inhibition: Alpha oscillations modulate attenuation and amplification of neural activity in the awake resting state / Lombardi, Fabrizio; Herrmann, Hans J; Parrino, Liborio; Plenz, Dietmar; Scarpetta, Silvia; Vaudano, Anna Elisabetta; de Arcangelis, Lucilla; Shriki, Oren. - In: CELL REPORTS. - ISSN 2211-1247. - 42:10(2023), pp. 113162-113163. [10.1016/j.celrep.2023.113162]
Lombardi, Fabrizio; Herrmann, Hans J; Parrino, Liborio; Plenz, Dietmar; Scarpetta, Silvia; Vaudano, Anna Elisabetta; de Arcangelis, Lucilla; Shriki, Oren
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1319530
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