Neuron and neural network studies are remarkably fostered by novel stimulation and recording systems, which often make use of biochips fabricated with advanced electronic technologies and, notably, micro and nanoscale CMOS. Models of the transduction mechanisms involved in the sensor and recording of the neuron activity are useful to optimize the sensing device architecture and its coupling to the readout circuits, as well as to interpret the measured data. Starting with an overview of recently published integrated active and passive micro/nano-electrode sensing devices for in-vitro studies fabricated with modern (CMOS based) micro-nano technology, this paper presents a mixed-mode device-circuit numerical analytical multiscale and multiphysics simulation methodology to describe the neuron-sensor coupling, suitable to derive useful design guidelines. A few representative structures and coupling conditions are analyzed in more detail in terms of the most relevant electrical figures of merit including signal-to-noise ratio.
Multiscale simulation analysis of passive and active micro/nano-electrodes for CMOS-based in-vitro neural sensing devices / Leva, Federico; Selmi, Luca; Palestri, Pierpaolo. - In: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A: MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. - ISSN 1364-503X. - 380:2228(2022), pp. 1-23. [10.1098/rsta.2021.0013]
Multiscale simulation analysis of passive and active micro/nano-electrodes for CMOS-based in-vitro neural sensing devices
Federico Leva
Writing – Original Draft Preparation
;Luca SelmiWriting – Original Draft Preparation
;Pierpaolo PalestriWriting – Original Draft Preparation
2022
Abstract
Neuron and neural network studies are remarkably fostered by novel stimulation and recording systems, which often make use of biochips fabricated with advanced electronic technologies and, notably, micro and nanoscale CMOS. Models of the transduction mechanisms involved in the sensor and recording of the neuron activity are useful to optimize the sensing device architecture and its coupling to the readout circuits, as well as to interpret the measured data. Starting with an overview of recently published integrated active and passive micro/nano-electrode sensing devices for in-vitro studies fabricated with modern (CMOS based) micro-nano technology, this paper presents a mixed-mode device-circuit numerical analytical multiscale and multiphysics simulation methodology to describe the neuron-sensor coupling, suitable to derive useful design guidelines. A few representative structures and coupling conditions are analyzed in more detail in terms of the most relevant electrical figures of merit including signal-to-noise ratio.File | Dimensione | Formato | |
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