Objective The aim was to identify any association between imaging signs of vessel wall inflammation (positron emission tomography-CT (PET-CT) score and CT/MR wall thickening) and synchronous and subsequent vascular damage (stenoses/dilations) in patients with large vessel vasculitis (LVV). Methods Consecutive patients with LVV referred to a tertiary centre in 2007-2020 with baseline PET-CT and morphological imaging (CT/MR angiography) performed within 3 months were included. All available PET-CT and CT/MR scans were reviewed to assess PET-CT uptake (4-point semi-quantitative score), wall thickening, stenoses and dilations for 15 vascular segments. The associations of baseline PET score and CT/MR wall thickening with synchronous and incident stenoses/dilations at CT/MR performed 6-30 months from baseline were evaluated in per-segment and per-patient analyses. Respective areas under the receiver operating characteristic curve (AUC) were calculated. Results We included 100 patients with LVV (median age: 48 years, 22% males). Baseline PET score and wall thickening were strongly associated (Cuzick non-parametric test for trend across order groups (NPtrend) <0.001). The association with synchronous stenoses/dilations was weak for PET score (NPtrend=0.01) and strong for wall thickening (p<0.001). In per-patient analyses, sensitivity/specificity for ≥1 synchronous stenoses/dilations were 44%/67% for PET score ≥2 and 66.7%/60.5% for wall thickening. Subsequent CTs/MRs were available in 28 patients, with seven incident stenoses/dilations. Baseline PET score was strongly associated with incident stenoses/dilations (p=0.001), while baseline wall thickening was not (p=0.708), with AUCs for incident stenoses/dilations of 0.80 for PET score and 0.52 for wall thickening. Conclusion PET score and wall thickening are strongly associated, but only baseline PET score is a good predictor of incident vessel wall damage in LVV.

Vessel inflammation and morphological changes in patients with large vessel vasculitis: A retrospective study / Besutti, G.; Muratore, F.; Mancuso, P.; Ferrari, M.; Galli, E.; Spaggiari, L.; Monelli, F.; Casali, M.; Versari, A.; Boiardi, L.; Marvisi, C.; Ligabue, G.; Pattacini, P.; Giorgi Rossi, P.; Salvarani, C.. - In: RMD OPEN. - ISSN 2056-5933. - 8:1(2022), pp. e001977-N/A. [10.1136/rmdopen-2021-001977]

Vessel inflammation and morphological changes in patients with large vessel vasculitis: A retrospective study

Besutti G.;Muratore F.;Ferrari M.;Monelli F.;Versari A.;Marvisi C.;Ligabue G.;Salvarani C.
2022

Abstract

Objective The aim was to identify any association between imaging signs of vessel wall inflammation (positron emission tomography-CT (PET-CT) score and CT/MR wall thickening) and synchronous and subsequent vascular damage (stenoses/dilations) in patients with large vessel vasculitis (LVV). Methods Consecutive patients with LVV referred to a tertiary centre in 2007-2020 with baseline PET-CT and morphological imaging (CT/MR angiography) performed within 3 months were included. All available PET-CT and CT/MR scans were reviewed to assess PET-CT uptake (4-point semi-quantitative score), wall thickening, stenoses and dilations for 15 vascular segments. The associations of baseline PET score and CT/MR wall thickening with synchronous and incident stenoses/dilations at CT/MR performed 6-30 months from baseline were evaluated in per-segment and per-patient analyses. Respective areas under the receiver operating characteristic curve (AUC) were calculated. Results We included 100 patients with LVV (median age: 48 years, 22% males). Baseline PET score and wall thickening were strongly associated (Cuzick non-parametric test for trend across order groups (NPtrend) <0.001). The association with synchronous stenoses/dilations was weak for PET score (NPtrend=0.01) and strong for wall thickening (p<0.001). In per-patient analyses, sensitivity/specificity for ≥1 synchronous stenoses/dilations were 44%/67% for PET score ≥2 and 66.7%/60.5% for wall thickening. Subsequent CTs/MRs were available in 28 patients, with seven incident stenoses/dilations. Baseline PET score was strongly associated with incident stenoses/dilations (p=0.001), while baseline wall thickening was not (p=0.708), with AUCs for incident stenoses/dilations of 0.80 for PET score and 0.52 for wall thickening. Conclusion PET score and wall thickening are strongly associated, but only baseline PET score is a good predictor of incident vessel wall damage in LVV.
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e001977
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Vessel inflammation and morphological changes in patients with large vessel vasculitis: A retrospective study / Besutti, G.; Muratore, F.; Mancuso, P.; Ferrari, M.; Galli, E.; Spaggiari, L.; Monelli, F.; Casali, M.; Versari, A.; Boiardi, L.; Marvisi, C.; Ligabue, G.; Pattacini, P.; Giorgi Rossi, P.; Salvarani, C.. - In: RMD OPEN. - ISSN 2056-5933. - 8:1(2022), pp. e001977-N/A. [10.1136/rmdopen-2021-001977]
Besutti, G.; Muratore, F.; Mancuso, P.; Ferrari, M.; Galli, E.; Spaggiari, L.; Monelli, F.; Casali, M.; Versari, A.; Boiardi, L.; Marvisi, C.; Ligabue, G.; Pattacini, P.; Giorgi Rossi, P.; Salvarani, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1271418
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