1. The effect on rat catalepsy induced by Δ 9- tetrahydrocannabinol (Δ 9-THC) in association with haloperidol (HP) or clozapine (CLOZ) administration was investigated. 2. Δ 9-THC dose-dependently increased HP (0.05 -1 mg kg -1, s.c.)-induced rat catalepsy, while no catalepsy was observed after CLOZ (1-20mg kg -1, s.c.) or Δ 9-THC + CLOZ administration. 3. The CB 1 antagonist SR141716A (0.5-5 mg kg -1, i.p.) reversed the increase mediated by Δ 9-THC on HP-induced catalepsy. 4. The D 2 agonist quinpirole completely reversed the catalepsy induced by both HP and HP + Δ 9-THC; however, higher doses of quinpirole were needed in the presence of Δ 9-THC. 5. The M 1 antagonist scopolamine and α 2 antagonist yohimbine were able to reduce the catalepsy induced by HP and HP + Δ 9-THC in a similar manner. 6. CLOZ and the 5-HT 2A/2C antagonists ritanserin, RS102221 and SB242084 were more effective in antagonizing HP than HP + Δ 9-THC-induced catalepsy. 7. HP and CLOZ failed to inhibit in vitro [ 3H]CP-55,940 binding, while Δ 9-THC and SR141716A did not show an appreciable affinity for the D 2 receptor. 8. It was suggested that the different effects on rat catalepsy induced by Δ 9-THC following HP or CLOZ administration may depend on the receptor-binding profiles of the two antipsychotics. 9. The preferential use of CLOZ rather than HP in the treatment of psychotic symptoms in cannabis abusers was discussed.

Haloperidol, but not clozapine, produces dramatic catalepsy in Δ 9-THC-treated rats: Possible clinical implications / Marchese, G.; Casti, P.; Ruiu, S.; Saba, P.; Sanna, A.; Casu, G.; Pani, L.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 140:3(2003), pp. 520-526. [10.1038/sj.bjp.0705478]

Haloperidol, but not clozapine, produces dramatic catalepsy in Δ 9-THC-treated rats: Possible clinical implications

Casu G.;Pani L.
2003

Abstract

1. The effect on rat catalepsy induced by Δ 9- tetrahydrocannabinol (Δ 9-THC) in association with haloperidol (HP) or clozapine (CLOZ) administration was investigated. 2. Δ 9-THC dose-dependently increased HP (0.05 -1 mg kg -1, s.c.)-induced rat catalepsy, while no catalepsy was observed after CLOZ (1-20mg kg -1, s.c.) or Δ 9-THC + CLOZ administration. 3. The CB 1 antagonist SR141716A (0.5-5 mg kg -1, i.p.) reversed the increase mediated by Δ 9-THC on HP-induced catalepsy. 4. The D 2 agonist quinpirole completely reversed the catalepsy induced by both HP and HP + Δ 9-THC; however, higher doses of quinpirole were needed in the presence of Δ 9-THC. 5. The M 1 antagonist scopolamine and α 2 antagonist yohimbine were able to reduce the catalepsy induced by HP and HP + Δ 9-THC in a similar manner. 6. CLOZ and the 5-HT 2A/2C antagonists ritanserin, RS102221 and SB242084 were more effective in antagonizing HP than HP + Δ 9-THC-induced catalepsy. 7. HP and CLOZ failed to inhibit in vitro [ 3H]CP-55,940 binding, while Δ 9-THC and SR141716A did not show an appreciable affinity for the D 2 receptor. 8. It was suggested that the different effects on rat catalepsy induced by Δ 9-THC following HP or CLOZ administration may depend on the receptor-binding profiles of the two antipsychotics. 9. The preferential use of CLOZ rather than HP in the treatment of psychotic symptoms in cannabis abusers was discussed.
140
3
520
526
Haloperidol, but not clozapine, produces dramatic catalepsy in Δ 9-THC-treated rats: Possible clinical implications / Marchese, G.; Casti, P.; Ruiu, S.; Saba, P.; Sanna, A.; Casu, G.; Pani, L.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 140:3(2003), pp. 520-526. [10.1038/sj.bjp.0705478]
Marchese, G.; Casti, P.; Ruiu, S.; Saba, P.; Sanna, A.; Casu, G.; Pani, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1212075
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