Tuberculosis (TB) is a major global health problem and control of the disease is hampered by the increasing emergence of multidrug resistance (MDR) strains. Novel drugs are urgently needed to overcome drug resistance. Among the most relevant targets of the past 3 years, herein we consider nine enzymes that have been studied in a target-based approach. These targets are involved mainly in the biosynthesis of the cell wall, α-glucan, coenzyme A and acyl carrier protein precursor, and in energy production, DNA metabolism, and pyrimidine synthesis. Some leads and many hits have been discovered using a target-based approach and can be further developed in a drug discovery process.

Target-based approaches for the discovery of new antimycobacterial drugs / Borsari, Chiara; Ferrari, Stefania; Venturelli, Alberto; Costi, Maria Paola. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 22:3(2017), pp. 576-584. [10.1016/j.drudis.2016.11.014]

Target-based approaches for the discovery of new antimycobacterial drugs

Borsari, Chiara;Ferrari, Stefania;Venturelli, Alberto;Costi, Maria Paola
2017

Abstract

Tuberculosis (TB) is a major global health problem and control of the disease is hampered by the increasing emergence of multidrug resistance (MDR) strains. Novel drugs are urgently needed to overcome drug resistance. Among the most relevant targets of the past 3 years, herein we consider nine enzymes that have been studied in a target-based approach. These targets are involved mainly in the biosynthesis of the cell wall, α-glucan, coenzyme A and acyl carrier protein precursor, and in energy production, DNA metabolism, and pyrimidine synthesis. Some leads and many hits have been discovered using a target-based approach and can be further developed in a drug discovery process.
2017
23-nov-2016
22
3
576
584
Target-based approaches for the discovery of new antimycobacterial drugs / Borsari, Chiara; Ferrari, Stefania; Venturelli, Alberto; Costi, Maria Paola. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 22:3(2017), pp. 576-584. [10.1016/j.drudis.2016.11.014]
Borsari, Chiara; Ferrari, Stefania; Venturelli, Alberto; Costi, Maria Paola
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1152933
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