Angiotensin-converting enzyme (ACE)-inhibitory peptides released from camel milk after simulated gastro-intestinal digestion were identified. The hydrolysis degree increased during digestion. The highest ACE-inhibitory activity was found in the post-pancreatic <3 kDa fraction. Peptides responsible for the biological activity were isolated by reversed-phase high-performance liquid chromatography and identified by mass spectrometry. Among the identified sequences, 17 were identical to known bioactive peptides with ACE-inhibitory activity. Based on previous structureeactivity relationship studies, the sequence of some peptides allowed us to anticipate the presence of biological activities. The antihypertensive tripeptide isoleucine-proline-proline (IPP) was identified and quantified in digested camel milk. The amount of released IPP was 2.56 ± 0.15 mg L1 of milk. For the first time, we showed that IPP is released during the gastro-intestinal digestion of camel milk k-casein. This research provides the basis to increase the exploitation of the health benefits of camel milk.
|Data di pubblicazione:||2016|
|Titolo:||Release of angiotensin converting enzyme-inhibitory peptides during in vitro gastro-intestinal digestion of camel milk|
|Autore/i:||Tagliazucchi, Davide; Shamsia, Sherif; Conte, Angela|
|Digital Object Identifier (DOI):||10.1016/j.idairyj.2016.01.009|
|Codice identificativo ISI:||WOS:000373543100016|
|Codice identificativo Scopus:||2-s2.0-84957586017|
|Citazione:||Release of angiotensin converting enzyme-inhibitory peptides during in vitro gastro-intestinal digestion of camel milk / Tagliazucchi, Davide; Shamsia, Sherif; Conte, Angela. - In: INTERNATIONAL DAIRY JOURNAL. - ISSN 0958-6946. - STAMPA. - 56(2016), pp. 119-128.|
|Tipologia||Articolo su rivista|
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