The drug release kinetics from a matrix is often affected by the matrix geometry. To compensate for the influence of the matrix geometry on the drug release, a nonhomogeneous drug distribution has been suggested. Keeping in mind this approach, a theoretical mathematical model to calculate the drug distribution profile according to The matrix geometry is proposed. This approach could be useful in achieving the desired drug release kinetics without varying the matrix geometry.
A theoretical model for the calculation of the drug distribution profile in matrices of different shape to achieve the desired drug release kinetics / Forni, Flavio; Vandelli, Maria Angela; Borghi, Massimo. - In: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - ISSN 0363-9045. - STAMPA. - 22:(1996), pp. 1083-1087.
A theoretical model for the calculation of the drug distribution profile in matrices of different shape to achieve the desired drug release kinetics
FORNI, Flavio;VANDELLI, Maria Angela;BORGHI, Massimo
1996
Abstract
The drug release kinetics from a matrix is often affected by the matrix geometry. To compensate for the influence of the matrix geometry on the drug release, a nonhomogeneous drug distribution has been suggested. Keeping in mind this approach, a theoretical mathematical model to calculate the drug distribution profile according to The matrix geometry is proposed. This approach could be useful in achieving the desired drug release kinetics without varying the matrix geometry.
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