This proteomic study confirms the previous finding of alterations in urinary proteins excreted in MOH patients. Some of these proteins, identified as over-expressed particularly in NSAIDs abusers, were related to different renal dysfunctions and, probably in the development of CA. Proteomic analysis of urine proteins by the combination of 2-DE and MS could improve the knowledge of the pathophysiology of the MOH condition and identify early biomarkers to prevent the potential drug overuse-induced nephrotoxicity
Evaluation of a possible relationship between medication-overuse headache and potential renal dysfunctions by a proteomic study on urine samples / Bellei, Elisa; Monari, Emanuela; Bergamini, Stefania; Cuoghi, Aurora; Tomasi, Aldo; Guerzoni, Simona; A., Bazzocchi; Pini, Luigi Alberto. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - STAMPA. - 13(suppl):(2012), pp. S17-S17. (Intervento presentato al convegno XXVI National Congress of the Italian Society for the Study of Headaches. Pharmacological therapies and beyond tenutosi a Modena, Italy nel October 26 – 28, 2012).
Evaluation of a possible relationship between medication-overuse headache and potential renal dysfunctions by a proteomic study on urine samples
BELLEI, Elisa;MONARI, Emanuela;BERGAMINI, Stefania;CUOGHI, Aurora;TOMASI, Aldo;GUERZONI, Simona;PINI, Luigi Alberto
2012
Abstract
This proteomic study confirms the previous finding of alterations in urinary proteins excreted in MOH patients. Some of these proteins, identified as over-expressed particularly in NSAIDs abusers, were related to different renal dysfunctions and, probably in the development of CA. Proteomic analysis of urine proteins by the combination of 2-DE and MS could improve the knowledge of the pathophysiology of the MOH condition and identify early biomarkers to prevent the potential drug overuse-induced nephrotoxicity
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