BACKGROUND: This paper examines a new material composed of polylactic and polyglycolic acids mixed with destrane easy to handle in bone defect reconstruction in periodontology and implantology: its name is fisiograft. METHODS: According to the European directives, fisiograft was checked for some biological tests selected for its specific use. In particular, tests of cytotoxicity, genotoxicity, sensitization and implantation in rabbit's femurs were carried out. RESULTS: The results show that the composite material is not cytotoxic when it is in direct and indirect contact with murine fibroblasts. It is not genotoxic and not allergenic. The implantation in rabbit, already after 30 days, shows that around the material there is a rapid bone growth and the material is reabsorbing. The degradation is suitable for its clinical use. CONCLUSIONS: Fisiograft showed to be biocompatible, easy to handle and its degradation kinetics in bone is appropriate.
Valutazione della biocompatibilità del fisiograft per difetti ossei / Gatti, Antonietta; Monari, Emanuela; Tanza, D.; Betti, V.. - In: MINERVA STOMATOLOGICA. - ISSN 0026-4970. - STAMPA. - 48 (6 supp 1):(1999), pp. 47-52.
Valutazione della biocompatibilità del fisiograft per difetti ossei
GATTI, Antonietta;MONARI, Emanuela;
1999
Abstract
BACKGROUND: This paper examines a new material composed of polylactic and polyglycolic acids mixed with destrane easy to handle in bone defect reconstruction in periodontology and implantology: its name is fisiograft. METHODS: According to the European directives, fisiograft was checked for some biological tests selected for its specific use. In particular, tests of cytotoxicity, genotoxicity, sensitization and implantation in rabbit's femurs were carried out. RESULTS: The results show that the composite material is not cytotoxic when it is in direct and indirect contact with murine fibroblasts. It is not genotoxic and not allergenic. The implantation in rabbit, already after 30 days, shows that around the material there is a rapid bone growth and the material is reabsorbing. The degradation is suitable for its clinical use. CONCLUSIONS: Fisiograft showed to be biocompatible, easy to handle and its degradation kinetics in bone is appropriate.
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