Two types of composite materials for bone repair were produced at Imperial College of London, one of Bioglass® dextran resorbable matrix and the second of Biog|ass® and a non resorbable polysulphone polymer matrix. Three samples ofthe first and a fourth sample ofthe second were sterilized and implanted in drilled holes in a sheep's mandible and also in tibial defects. After 3 months the materials with the surrounding tissues were explanted, fixed and radiographed in order to have the macroscopic relationship between the material and bone. Sections were prepared for scanning electron microscopic observations and X-ray microanalyses to detect any resorption of the materials and the interface developed with bone, Results show good biocompatibility for all four materials. The polysulphone/glass showed a small surface degradation. The bioactive glass-dextran composite showed maximum resorption and at times it was difficult to recognize the site of implantation. The dextran-glass composite was very promising in mandibular bone augmentation or repair of bone defects. The polysulphone- bioactive glass composite may be more useful for long term implants.
NEW PUTTY COMPOSITE MATERIALS FOR BONE DEFECTS IN DENTISTRY / Gatti, Antonietta; L. L., Hench; Monari, Emanuela; J., Thompson; D., Tanza. - STAMPA. - 11:(1998), pp. 349-352. (Intervento presentato al convegno 11th International Symposium on Ceramics in Medicine tenutosi a New York City, USA nel 5-8 November 1998).
NEW PUTTY COMPOSITE MATERIALS FOR BONE DEFECTS IN DENTISTRY
GATTI, Antonietta;MONARI, Emanuela;
1998
Abstract
Two types of composite materials for bone repair were produced at Imperial College of London, one of Bioglass® dextran resorbable matrix and the second of Biog|ass® and a non resorbable polysulphone polymer matrix. Three samples ofthe first and a fourth sample ofthe second were sterilized and implanted in drilled holes in a sheep's mandible and also in tibial defects. After 3 months the materials with the surrounding tissues were explanted, fixed and radiographed in order to have the macroscopic relationship between the material and bone. Sections were prepared for scanning electron microscopic observations and X-ray microanalyses to detect any resorption of the materials and the interface developed with bone, Results show good biocompatibility for all four materials. The polysulphone/glass showed a small surface degradation. The bioactive glass-dextran composite showed maximum resorption and at times it was difficult to recognize the site of implantation. The dextran-glass composite was very promising in mandibular bone augmentation or repair of bone defects. The polysulphone- bioactive glass composite may be more useful for long term implants.
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