OBJECTIVE: To investigate the hypothesis that Z-score criteria represent a reliable predictor of implantation rate and pregnancy outcome in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles, excluding the possibility of embryo selection before the embryo transfer. DESIGN: Retrospective clinical study. SETTING: Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, Arcispedale S. Maria Nuova (ASMN), Reggio Emilia, Italy. PATIENT(S): We analyzed 393 pregnancies obtained by IVF or ICSI cycles. INTERVENTION(S): Morphologic evaluations of Z-score in pre-embryos obtained from IVF or ICSI cycles. MAIN OUTCOME MEASURE(S): Evaluations of Z-scores, implantation rate, and clinical pregnancy outcome. RESULT(S): We did not find any statistically significant correlation between the Z-score of 1032 embryos transferred in 393 embryo transfers and the implantation rate or the pregnancy outcome. In particular, the best Z-score identified (Z1, 7.2%) did not seem to correlate with embryo implantation rate or pregnancy outcomes any better than those with worse scores (Z2, 6.9% and Z3, 85.9%). CONCLUSION(S): Our results seem to confirm that Z-score alone cannot be considered a better tool than standard morphologic criteria for identifying, controlling, or selecting embryos with a better chance of successful ongoing pregnancy.

Limited importance of pre-embryo pronuclear morphology (zygote score) in assisted reproduction outcome in the absence of embryo cryopreservation / Nicoli, A; Valli, B; Di Girolamo, R; Di Tommaso, B; Gallinelli, A; LA SALA, Giovanni Battista. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - ELETTRONICO. - 88:4(2007), pp. 1167-1173. [10.1016/j.fertnstert.2007.01.066]

Limited importance of pre-embryo pronuclear morphology (zygote score) in assisted reproduction outcome in the absence of embryo cryopreservation.

LA SALA, Giovanni Battista
2007

Abstract

OBJECTIVE: To investigate the hypothesis that Z-score criteria represent a reliable predictor of implantation rate and pregnancy outcome in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles, excluding the possibility of embryo selection before the embryo transfer. DESIGN: Retrospective clinical study. SETTING: Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, Arcispedale S. Maria Nuova (ASMN), Reggio Emilia, Italy. PATIENT(S): We analyzed 393 pregnancies obtained by IVF or ICSI cycles. INTERVENTION(S): Morphologic evaluations of Z-score in pre-embryos obtained from IVF or ICSI cycles. MAIN OUTCOME MEASURE(S): Evaluations of Z-scores, implantation rate, and clinical pregnancy outcome. RESULT(S): We did not find any statistically significant correlation between the Z-score of 1032 embryos transferred in 393 embryo transfers and the implantation rate or the pregnancy outcome. In particular, the best Z-score identified (Z1, 7.2%) did not seem to correlate with embryo implantation rate or pregnancy outcomes any better than those with worse scores (Z2, 6.9% and Z3, 85.9%). CONCLUSION(S): Our results seem to confirm that Z-score alone cannot be considered a better tool than standard morphologic criteria for identifying, controlling, or selecting embryos with a better chance of successful ongoing pregnancy.
2007
88
4
1167
1173
Limited importance of pre-embryo pronuclear morphology (zygote score) in assisted reproduction outcome in the absence of embryo cryopreservation / Nicoli, A; Valli, B; Di Girolamo, R; Di Tommaso, B; Gallinelli, A; LA SALA, Giovanni Battista. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - ELETTRONICO. - 88:4(2007), pp. 1167-1173. [10.1016/j.fertnstert.2007.01.066]
Nicoli, A; Valli, B; Di Girolamo, R; Di Tommaso, B; Gallinelli, A; LA SALA, Giovanni Battista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/853932
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