OBJECTIVE: To evaluate the effect of the 2004 Italian regulations (insemination of <or=3 oocytes/cycle, transfer of all embryos, prohibition of embryo cryopreservation) on outcomes of assisted reproduction treatment (ART). DESIGN: Case-control study. SETTING: The Center of Reproductive Medicine, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. PATIENT(S): Women undergoing ART for the first time. INTERVENTION(S): Comparing outcomes of ART between 2 years before (n = 900) and after (n = 936) the law's implementation (March 10, 2004). MAIN OUTCOME MEASURE(S): Rates of fertilization, pregnancy, "take-home baby," and multiple pregnancies. RESULT(S): During the pre-law period, statistically significantly more patients reached embryo transfer (odds ratio 1.9; 95% CI, 1.5, 2.5), and embryo transfer rate per cycle was statistically significantly higher (3.1 +/- 1.7 vs. 2.2 +/- 0.7), but the overall transfer of good embryos was lower (OR 0.6; 95% CI, 0.5, 0.8). The pregnancy rates per aspiration cycle were similar between the periods, but the pregnancy rate per embryo transfer and birth rate with at least one liveborn baby per embryo transfer were statistically significantly lower in the pre-law period (OR 0.7; 95% CI, 0.5, 0.9). The multiple births rate was not different between the two periods. CONCLUSION(S): In contrast to prior pessimistic expectations, the obligation to transfer all available embryos produced from <or=3 inseminated oocytes neither reduced success rates of ART nor increased the multiple births rate.

The effect of legislation on outcomes of assisted reproduction technology: lessons from the 2004 Italian law / LA SALA, Giovanni Battista; Villani, Mt; Nicoli, A; Valli, B; Iannotti, F; Blickstein, I.. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - ELETTRONICO. - 89:4(2008), pp. 854-859. [10.1016/j.fertnstert.2007.04.051]

The effect of legislation on outcomes of assisted reproduction technology: lessons from the 2004 Italian law.

LA SALA, Giovanni Battista;
2008

Abstract

OBJECTIVE: To evaluate the effect of the 2004 Italian regulations (insemination of
2008
89
4
854
859
The effect of legislation on outcomes of assisted reproduction technology: lessons from the 2004 Italian law / LA SALA, Giovanni Battista; Villani, Mt; Nicoli, A; Valli, B; Iannotti, F; Blickstein, I.. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - ELETTRONICO. - 89:4(2008), pp. 854-859. [10.1016/j.fertnstert.2007.04.051]
LA SALA, Giovanni Battista; Villani, Mt; Nicoli, A; Valli, B; Iannotti, F; Blickstein, I.
File in questo prodotto:
File Dimensione Formato  
The effect of legislation on outcomes of assisted reproduction technology lessons from the 2004 Italian law. .pdf

Accesso riservato

Tipologia: Abstract
Dimensione 94.66 kB
Formato Adobe PDF
94.66 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/853926
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 16
social impact