ln low concentratiuns the tetramlne disulfide benextramine potentiated the contracture of the isolated frog rectus abdominus muscle caused by acethilcholine but in presence of physiostigmine or in presence of higher concentration only inhibited the contracture by carbachol or butirrilcholine. The all-carbon analog of benextramine only inhibit the the effect of acetilcholine. The inhibitori effect of benextramine and it all-carbon analog were noncompèotitiveand ready reversible but the potentiating effect of benextramine was not readly reversible.
Potentiation and inhibition ofnicotinic effects on striated muscle by the tetramlne disulfide benextramineB. G. Benfey, L. Brasili, C. Melchiorre, B. Belleau / B. G., Benfey; Brasili, Livio; C., Melchiorre; B., Belleau. - In: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. - ISSN 0008-4212. - STAMPA. - 58:(1980), pp. 984-988.
Potentiation and inhibition ofnicotinic effects on striated muscle by the tetramlne disulfide benextramineB. G. Benfey, L. Brasili, C. Melchiorre, B. Belleau
BRASILI, Livio;
1980
Abstract
ln low concentratiuns the tetramlne disulfide benextramine potentiated the contracture of the isolated frog rectus abdominus muscle caused by acethilcholine but in presence of physiostigmine or in presence of higher concentration only inhibited the contracture by carbachol or butirrilcholine. The all-carbon analog of benextramine only inhibit the the effect of acetilcholine. The inhibitori effect of benextramine and it all-carbon analog were noncompèotitiveand ready reversible but the potentiating effect of benextramine was not readly reversible.
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