The tetramine disulfide benextramine irreversibly blocked the noradrenaline-induced contraction of the isolated rabbit aorta in a manner similar to that observed with phenoxvbenzamine. Cysteamlne abolished abolished the benextramine blockade but not the phenoxybenzamine.Incubation of aortic tissue with benextramine prior to phenoxybenzamine exposure and follwed by cysteamine treatment led to a recovery of the noradrenaline response that depended on the dose of benextramine. Thus benextramine protected alpha adrenoceptors against phenoxybenzamine blockade.
Reactivation by cysteamine of vascular alpha-adrenoceptors blocked by the tetraminedisulfide benextramine and interaction of benextramine with phenoxybenzamine / Brasili, Livio; C., Melchiorre; B., Belleau; B. G., Benfey. - In: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. - ISSN 0008-4212. - STAMPA. - 58:(1980), pp. 1490-1493.
Reactivation by cysteamine of vascular alpha-adrenoceptors blocked by the tetraminedisulfide benextramine and interaction of benextramine with phenoxybenzamine
BRASILI, Livio;
1980
Abstract
The tetramine disulfide benextramine irreversibly blocked the noradrenaline-induced contraction of the isolated rabbit aorta in a manner similar to that observed with phenoxvbenzamine. Cysteamlne abolished abolished the benextramine blockade but not the phenoxybenzamine.Incubation of aortic tissue with benextramine prior to phenoxybenzamine exposure and follwed by cysteamine treatment led to a recovery of the noradrenaline response that depended on the dose of benextramine. Thus benextramine protected alpha adrenoceptors against phenoxybenzamine blockade.Pubblicazioni consigliate
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