1 The efficacy and affinity of nine pentatomic cyclic muscarinic agonists were determined on theguinea-pig ileum, according to the method of Furchgott & Bursztyn {1967). 2 Tbe efficacy and affinity of these agonists are affected differently by structural modifications.3 Our results suggest that a strong dipole oriented in the same direction as that of the hydroxy groupof muscarine, or the presence of a polarizable atom in the same position, are important for efficacy
Affinity and efficacy correlate with chemical structuremore than potency does in a series of pentatomic cyclicmuscarinic agonists / P., Angeli; Brasili, Livio; M., Giannella; F., Gualtierix; M., Pigini. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - STAMPA. - 85:(1985), pp. 783-786.
Affinity and efficacy correlate with chemical structuremore than potency does in a series of pentatomic cyclicmuscarinic agonists
BRASILI, Livio;
1985
Abstract
1 The efficacy and affinity of nine pentatomic cyclic muscarinic agonists were determined on theguinea-pig ileum, according to the method of Furchgott & Bursztyn {1967). 2 Tbe efficacy and affinity of these agonists are affected differently by structural modifications.3 Our results suggest that a strong dipole oriented in the same direction as that of the hydroxy groupof muscarine, or the presence of a polarizable atom in the same position, are important for efficacy
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