Ammonium salts added to isolated rat liver mitochondria deviate alpha-ketoglutarate to glutamate synthesis, thus decreasing its availability as respiratory substrate. As a consequence a decrease of respiratory rate is observed which is paralleled by progressive mitochondrial swelling. It was demonstrated that L-carnitine may abolish this swelling thus improving structural and metabolic state of mitochondria.
Changes in mitochondrial activity caused by ammonium salts and the protective effect of carnitine / Bellei, Monica; Battelli, D; Guarriero, Dm; Muscatello, U; Dilisa, F; Siliprandi, N; Bobyleva Guarriero, V.. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 158(1):(1989), pp. 181-188.
Changes in mitochondrial activity caused by ammonium salts and the protective effect of carnitine
BELLEI, Monica;
1989
Abstract
Ammonium salts added to isolated rat liver mitochondria deviate alpha-ketoglutarate to glutamate synthesis, thus decreasing its availability as respiratory substrate. As a consequence a decrease of respiratory rate is observed which is paralleled by progressive mitochondrial swelling. It was demonstrated that L-carnitine may abolish this swelling thus improving structural and metabolic state of mitochondria.
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