Ammonium salts added to isolated rat liver mitochondria deviate alpha-ketoglutarate to glutamate synthesis, thus decreasing its availability as respiratory substrate. As a consequence a decrease of respiratory rate is observed which is paralleled by progressive mitochondrial swelling. It was demonstrated that L-carnitine may abolish this swelling thus improving structural and metabolic state of mitochondria.
Changes in mitochondrial activity caused by ammonium salts and the protective effect of carnitine / Bellei, Monica; Battelli, D; Guarriero, Dm; Muscatello, U; Dilisa, F; Siliprandi, N; Bobyleva Guarriero, V.. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 158(1)(1989), pp. 181-188.
Data di pubblicazione: | 1989 |
Titolo: | Changes in mitochondrial activity caused by ammonium salts and the protective effect of carnitine |
Autore/i: | Bellei, Monica; Battelli, D; Guarriero, Dm; Muscatello, U; Dilisa, F; Siliprandi, N; Bobyleva Guarriero, V. |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 158(1) |
Pagina iniziale: | 181 |
Pagina finale: | 188 |
Codice identificativo ISI: | WOS:A1989R732300028 |
Codice identificativo Scopus: | 2-s2.0-0024540823 |
Codice identificativo Pubmed: | 2563222 |
Citazione: | Changes in mitochondrial activity caused by ammonium salts and the protective effect of carnitine / Bellei, Monica; Battelli, D; Guarriero, Dm; Muscatello, U; Dilisa, F; Siliprandi, N; Bobyleva Guarriero, V.. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 158(1)(1989), pp. 181-188. |
Tipologia | Articolo su rivista |
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