As the main iron storage site in the body and the main source of the iron-regulatory hormone, hepcidin, the liver plays a pivotal role in iron homeostasis. A variable degree of hepatic iron accumulation has long been recognized in a number of chronic liver diseases. Both alcoholic and non-alcoholic steatohepatitis display increased iron deposits in the liver, with an hepatocellular, mesenchymal, or mixed pattern, and recent reports have documented a concomitant aberrant hepcidin expression that could be linked to different coincidental pathogenic events (e.g. the etiological agent itself, necroinflammation, metabolic derangements, genetic predisposition). The present study reviews the pathogenic mechanisms of iron accumulation in steatohepatitis during alcoholic and non-alcoholic liver disease and the role of excess iron in chronic disease progression.
Iron and steatohepatitis / Corradini, Elena; Pietrangelo, Antonello. - In: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. - ISSN 0815-9319. - STAMPA. - 27(2)(2012), pp. 42-46.
Data di pubblicazione: | 2012 |
Titolo: | Iron and steatohepatitis. |
Autore/i: | Corradini, Elena; Pietrangelo, Antonello |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1440-1746.2011.07014.x |
Rivista: | |
Volume: | 27(2) |
Pagina iniziale: | 42 |
Pagina finale: | 46 |
Codice identificativo ISI: | WOS:000300047000009 |
Codice identificativo Scopus: | 2-s2.0-84856954278 |
Codice identificativo Pubmed: | 22320915 |
Citazione: | Iron and steatohepatitis / Corradini, Elena; Pietrangelo, Antonello. - In: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. - ISSN 0815-9319. - STAMPA. - 27(2)(2012), pp. 42-46. |
Tipologia | Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | |
---|---|---|---|
Corradini_et_al-2012-Journal_of_Gastroenterology_and_Hepatology.pdf | Versione dell'editore (versione pubblicata) | Open Access Visualizza/Apri |

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris