Anti-Müllerian hormone (AMH) has become the 'molecule of the moment' in the field of reproductive endocrinology. Indeed, it is valuable as a means of increasing understanding of ovarian pathophysiology and for guiding clinical management across a broad range of conditions. However, no normative values have been established for circulating AMH in healthy women. In this cross-sectional study, 277 healthy females (aged 18-50 years) were included. AMH was measured by commercial enzyme-linked immunosorbent assay. Serum AMH concentrations show a progressive decline with female ageing. The age-related changes in AMH were best fitted by a polynomial function. Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women. Age-specific normative values for circulating AMH concentration were established. AMH concentrations seem to be independent of the reproductive history of the patient.
Normal serum concentrations of anti-Müllerian hormone in women with regular menstrual cycles / A. L., Marca; G., Sighinolfi; S., Giulini; M., Traglia; C., Argento; C., Sala; C., Masciullo; Volpe, Annibale; D., Toniolo; LA MARCA, Antonio. - In: REPRODUCTIVE BIOMEDICINE ONLINE. - ISSN 1472-6491. - STAMPA. - 21:4(2010), pp. 463-469. [10.1016/j.rbmo.2010.05.009]
Normal serum concentrations of anti-Müllerian hormone in women with regular menstrual cycles
VOLPE, Annibale;LA MARCA , Antonio
2010
Abstract
Anti-Müllerian hormone (AMH) has become the 'molecule of the moment' in the field of reproductive endocrinology. Indeed, it is valuable as a means of increasing understanding of ovarian pathophysiology and for guiding clinical management across a broad range of conditions. However, no normative values have been established for circulating AMH in healthy women. In this cross-sectional study, 277 healthy females (aged 18-50 years) were included. AMH was measured by commercial enzyme-linked immunosorbent assay. Serum AMH concentrations show a progressive decline with female ageing. The age-related changes in AMH were best fitted by a polynomial function. Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women. Age-specific normative values for circulating AMH concentration were established. AMH concentrations seem to be independent of the reproductive history of the patient.
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