In vitro studies identified antifolate inhibitors ofLeishmania major Ptr1 that could be used withDhfr inhibitors to help treat parasitic infection. Incultured L. major, five Ptr1-targeting compoundsshowed efficacy against the parasite in combinationwith the Dhfr inhibitor pyrimethamine. One of thePtr1-targeting compounds also showed efficacy asmonotherapy. Ongoing studies include developingcompounds to use in tandem with the inhibitors.
Pteridinereductase (PTR1);dihydrofolatereductase (DHFR) / Costi, Maria Paola; Wade, R.. - In: SCIBX. - ISSN 1945-3477. - ELETTRONICO. - 4 (2):(2011), pp. 47-47.
Pteridinereductase (PTR1);dihydrofolatereductase (DHFR)
COSTI, Maria Paola;
2011
Abstract
In vitro studies identified antifolate inhibitors ofLeishmania major Ptr1 that could be used withDhfr inhibitors to help treat parasitic infection. Incultured L. major, five Ptr1-targeting compoundsshowed efficacy against the parasite in combinationwith the Dhfr inhibitor pyrimethamine. One of thePtr1-targeting compounds also showed efficacy asmonotherapy. Ongoing studies include developingcompounds to use in tandem with the inhibitors.
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